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    VDAC2 voltage dependent anion channel 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 836886, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VDAC2
    Official Full Name
    voltage dependent anion channel 2
    Primary source
    TAIR:AT5G67500
    Locus tag
    AT5G67500
    See related
    Araport:AT5G67500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 2; ATVDAC2; K9I9.6; K9I9_6; voltage dependent anion channel 2
    Summary
    Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol.
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    Genomic context

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    See VDAC2 in Genome Data Viewer
    Location:
    chromosome: 5
    Exon count:
    8
    Sequence:
    Chromosome: 5; NC_003076.8 (26935075..26937650)

    Chromosome 5 - NC_003076.8Genomic Context describing neighboring genes Neighboring gene formin homolog 6 Neighboring gene BTB and TAZ domain protein 4 Neighboring gene ncRNA Neighboring gene succinate dehydrogenase assembly factor Neighboring gene Translation protein SH3-like family protein Neighboring gene adenosine-5'-phosphosulfate (APS) kinase 4 Neighboring gene plant U-box 49 Neighboring gene Arabinanase/levansucrase/invertase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003076.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria. Robert N, et al. Plant Mol Biol, 2012 Mar. PMID 22294207
    2. Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis. Tateda C, et al. J Exp Bot, 2011 Oct. PMID 21705391, Free PMC Article
    3. Pathogen inducible voltage-dependent anion channel (AtVDAC) isoforms are localized to mitochondria membrane in Arabidopsis. Lee SM, et al. Mol Cells, 2009 Mar 31. PMID 19326079
    4. The hydrophobic proteome of mitochondrial membranes from Arabidopsis cell suspensions. Brugière S, et al. Phytochemistry, 2004 Jun. PMID 15276431
    5. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. AtVDAC2 has a main function in mitochondria
      Title: Voltage-dependent-anion-channels (VDACs) in Arabidopsis have a dual localization in the cell but show a distinct role in mitochondria.
    2. VDAC2 and VDAC4 are important for leaf development, the mitochondrial membrane potential, and pollen development.
      Title: Molecular and genetic characterization of the gene family encoding the voltage-dependent anion channel in Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    NM_001345833.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables voltage-gated monoatomic anion channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic anion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    NOT located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in mitochondrial outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plant-type cell wall HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    voltage dependent anion channel 2
    NP_001190641.1
    • voltage dependent anion channel 2 (VDAC2); CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 5 (TAIR:AT3G49920.1).
    NP_001318898.1
    • voltage dependent anion channel 2 (VDAC2); FUNCTIONS IN: voltage-gated anion channel activity; INVOLVED IN: response to bacterium, anion transport; LOCATED IN: in 7 components; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Porin, eukaryotic type (InterPro:IPR001925); BEST Arabidopsis thaliana protein match is: voltage dependent anion channel 5 (TAIR:AT3G49920.1); Has 1807 Blast hits to 1807 proteins in 277 species: Archae - 0; Bacteria - 0; Metazoa - 736; Fungi - 347; Plants - 385; Viruses - 0; Other Eukaryotes - 339 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003076.8 Reference assembly

      Range
      26935075..26937650
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_126150.5 → NP_201551.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_201551.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FJX3
      UniProtKB/TrEMBL
      A0A178UUR9, A0A5S9YIL5, A0A654GFB8
      Conserved Domains (1) summary
      cd07306
      Location:5 → 275
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    2. NM_001203712.1 → NP_001190641.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190641.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178UUR9, F4K3R8
      Conserved Domains (1) summary
      cd07306
      Location:5 → 302
      Porin3_VDAC; Voltage-dependent anion channel of the outer mitochondrial membrane

    3. NM_001345833.1 → NP_001318898.1  voltage dependent anion channel 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZE94, A0A7G2FKP9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FJX3.1

    Gene LinkOut

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