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    SNAP25 synaptosome associated protein 25 [ Bos taurus (domestic cattle) ]

    Gene ID: 540853, updated on 12-Oct-2024

    Summary

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    Official Symbol
    SNAP25provided by VGNC
    Official Full Name
    synaptosome associated protein 25provided by VGNC
    Primary source
    VGNC:VGNC:35051
    See related
    BGD:BT19369; Ensembl:ENSBTAG00000008323
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Also known as
    SNAP-25
    Orthologs
    human mouse all
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    Genomic context

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    See SNAP25 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 13 NC_037340.1 (3478006..3561820)

    Chromosome 13 - NC_037340.1Genomic Context describing neighboring genes Neighboring gene non-histone chromosomal protein HMG-14-like Neighboring gene ankyrin repeat and EF-hand domain containing 1 Neighboring gene uncharacterized LOC132346869 Neighboring gene uncharacterized LOC132346871 Neighboring gene U6 spliceosomal RNA Neighboring gene MKKS centrosomal shuttling protein Neighboring gene SLX4 interacting protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037340.1 Chromosome 13 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells. Zhao Y, et al. Proc Natl Acad Sci U S A, 2013 Aug 27. PMID 23940346, Free PMC Article
    2. Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells. Torregrosa-Hetland CJ, et al. Int J Biochem Cell Biol, 2013 Mar. PMID 23220175
    3. Tight coupling of the t-SNARE and calcium channel microdomains in adrenomedullary slices and not in cultured chromaffin cells. Lopez I, et al. Cell Calcium, 2007 Jun. PMID 17112584
    4. Dynamic association of the Ca2+ channel alpha1A subunit and SNAP-25 in round or neurite-emitting chromaffin cells. Andrés-Mateos E, et al. Eur J Neurosci, 2005 Nov. PMID 16262657
    5. High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E. Rickman C, et al. J Biol Chem, 2004 Jan 2. PMID 14551199

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In individual chromaffin cells, we tracked conformational changes in SNAP25 by total internal reflection fluorescence resonance energy transfer (FRET) microscopy while exocytotic catecholamine release from single vesicles was simultaneously recorded
      Title: Rapid structural change in synaptosomal-associated protein 25 (SNAP25) precedes the fusion of single vesicles with the plasma membrane in live chromaffin cells.
    2. dynamic experiments using TIRFM revealed that attenuation of cortical F-actin movement clearly diminishes the mobility of SNAP-25 clusters.
      Title: Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells.
    3. Stable syntaxin/SNAP-25 dimers are a central principle of the SNARE assembly pathway underlying regulated exocytosis.
      Title: High affinity interaction of syntaxin and SNAP-25 on the plasma membrane is abolished by botulinum toxin E.
    4. microdomains carrying syntaxin1/SNAP-25 and different types of calcium channels act as the sites for physiological granule fusion in "in situ" chromaffin cells
      Title: Tight coupling of the t-SNARE and calcium channel microdomains in adrenomedullary slices and not in cultured chromaffin cells.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC139754

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables SNAP receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables syntaxin-1 binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables voltage-gated potassium channel activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle fusion to presynaptic active zone membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    synaptosomal-associated protein 25
    Names
    synaptosomal-associated 25 kDa protein
    synaptosomal-associated protein, 25kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001076246.1 → NP_001069714.1  synaptosomal-associated protein 25

      See identical proteins and their annotated locations for NP_001069714.1

      Status: PROVISIONAL

      Source sequence(s)
      BC118237
      UniProtKB/Swiss-Prot
      Q17QQ3
      Related
      ENSBTAP00000010961.3, ENSBTAT00000010961.4
      Conserved Domains (3) summary
      cd15885
      Location:143 → 201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:10 → 82
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91 → 141
      SNAP-25; SNAP-25 family

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037340.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      3478006..3561820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005214074.4 → XP_005214131.1  synaptosomal-associated protein 25 isoform X2

      See identical proteins and their annotated locations for XP_005214131.1

      UniProtKB/TrEMBL
      A0A3Q1NFZ1
      Related
      ENSBTAP00000070650.1, ENSBTAT00000068441.2
      Conserved Domains (3) summary
      cd15885
      Location:143 → 201
      SNARE_SNAP25C; C-terminal SNARE motif of SNAP25
      cd15894
      Location:10 → 82
      SNARE_SNAP25N; N-terminal SNARE motif of SNAP25
      pfam00835
      Location:91 → 141
      SNAP-25; SNAP-25 family

    2. XM_059892741.1 → XP_059748724.1  synaptosomal-associated protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q17QQ3

    3. XM_059892742.1 → XP_059748725.1  synaptosomal-associated protein 25 isoform X1

      UniProtKB/Swiss-Prot
      Q17QQ3
      Related
      ENSBTAP00000071079.1, ENSBTAT00000071478.2
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q17QQ3.1 GenPept UniProtKB/Swiss-Prot:Q17QQ3

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