FBXL16 F-box and leucine rich repeat protein 16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: FBXL16provided by HGNC
Official Full Name: F-box and leucine rich repeat protein 16provided by HGNC
Primary source: HGNC:HGNC:14150
See related: Ensembl:ENSG00000127585 MIM:609082; AllianceGenome:HGNC:14150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Fbl16; C16orf22; c380A1.1
Summary: Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Expression: Biased expression in brain (RPKM 76.4), testis (RPKM 4.8) and 1 other tissue See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (692500..705801, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (696575..709982, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (742500..755801, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1alpha axis.
Title: MiR-1307-5p enhances fibroblast transdifferentiation to exacerbate chronic obstructive pulmonary disease through regulating FBXL16/HIF1α axis.
FBXL16 Promotes Endometrial Progesterone Resistance via PP2A(B55alpha) /Cyclin D1 Axis in Ishikawa.
Title: FBXL16 Promotes Endometrial Progesterone Resistance via PP2A(B55α) /Cyclin D1 Axis in Ishikawa.
Suppression of breast cancer progression by FBXL16 via oxygen-independent regulation of HIF1alpha stability.
Title: Suppression of breast cancer progression by FBXL16 via oxygen-independent regulation of HIF1α stability.
FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
Title: FBXL16 modulates the proliferation and autophagy in breast cancer cells via activating SRC-3-AKT signaling pathway.
The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7.
Title: The F-box protein FBXL16 up-regulates the stability of C-MYC oncoprotein by antagonizing the activity of the F-box protein FBW7.
the expression of FBXL16 reproducibly upregulated in p16INK4A and p14ARF knockdown HeLa cells
Title: FBXL16 is a novel E2F1-regulated gene commonly upregulated in p16INK4A- and p14ARF-silenced HeLa cells.

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of SCF ubiquitin ligase complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info

General protein information

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Preferred Names: F-box/LRR-repeat protein 16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_153350.4 → NP_699181.2 F-box/LRR-repeat protein 16

See identical proteins and their annotated locations for NP_699181.2

Status: VALIDATED

Source sequence(s)

Z92544, Z97653

Consensus CDS

CCDS10421.1

UniProtKB/Swiss-Prot

B3KR59, D3DU60, Q2MHR2, Q8N461, Q96S14, Q9UJI0

Related

ENSP00000380746.1, ENST00000397621.6

Conserved Domains (2) summary

cd09293
Location:201 → 413

AMN1; Antagonist of mitotic exit network protein 1

sd00034
Location:220 → 243

LRR_AMN1; leucine-rich repeat [structural motif]