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    Copb1 COPI coat complex subunit beta 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114023, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Copb1provided by RGD
    Official Full Name
    COPI coat complex subunit beta 1provided by RGD
    Primary source
    RGD:620861
    See related
    EnsemblRapid:ENSRNOG00000057623 AllianceGenome:RGD:620861
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable structural molecule activity. Involved in intra-Golgi vesicle-mediated transport. Located in Golgi apparatus and Golgi-associated vesicle. Part of COPI vesicle coat. Orthologous to human COPB1 (COPI coat complex subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Kidney (RPKM 365.1), Adrenal (RPKM 335.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Copb1 in Genome Data Viewer
    Location:
    1q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (177838751..177876688, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (168404334..168438589, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (183695480..183729569, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S14, pseudogene 6 Neighboring gene ribosomal protein S18-like 4 Neighboring gene uncharacterized LOC134485165 Neighboring gene proteasome 20S subunit alpha 1 Neighboring gene ATP synthase membrane subunit j, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Beta-COP is essential for transport of protein from the endoplasmic reticulum to the Golgi in vitro. Peter F, et al. J Cell Biol, 1993 Sep. PMID 8376457, Free PMC Article
    2. Direct and GTP-dependent interaction of ADP ribosylation factor 1 with coatomer subunit beta. Zhao L, et al. Proc Natl Acad Sci U S A, 1997 Apr 29. PMID 9114004, Free PMC Article
    3. Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes. Huang X, et al. J Cell Sci, 2004 Apr 15. PMID 15039458
    4. Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Duden R, et al. Cell, 1991 Feb 8. PMID 1840503
    5. The deubiquitinating enzyme UBPy/USP8 interacts with TrkA and inhibits neuronal differentiation in PC12 cells. Ceriani M, et al. Exp Cell Res, 2015 Apr 10. PMID 25662281

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A(1)R stimulation of the heart is associated with PLC-initiated PKC-epsilon translocation and association with RACK2
      Title: Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.
    2. RACK2 plays a role in epsilon-PKC anchoring in cardiac myofilaments.
      Title: Myofilament anchoring of protein kinase C-epsilon in cardiac myocytes.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables structural molecule activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of COPI vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of COPI vesicle coat IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in COPI-coated vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi-associated vesicle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    coatomer subunit beta
    Names
    beta-COP
    beta-coat protein
    coatomer protein complex, subunit beta 1
    receptor for activated C-kinase-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_080781.2 → NP_542959.1  coatomer subunit beta

      See identical proteins and their annotated locations for NP_542959.1

      Status: PROVISIONAL

      Source sequence(s)
      BC061882
      UniProtKB/Swiss-Prot
      P23514
      UniProtKB/TrEMBL
      A6I896, A6I897
      Related
      ENSRNOP00000072797.1, ENSRNOT00000083293.3
      Conserved Domains (4) summary
      sd00044
      Location:137 → 161
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:18 → 550
      Adaptin_N; Adaptin N terminal region
      pfam07718
      Location:667 → 807
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:813 → 944
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      177838751..177876688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008759660.3 → XP_008757882.1  coatomer subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008757882.1

      UniProtKB/Swiss-Prot
      P23514
      UniProtKB/TrEMBL
      A6I896, A6I897
      Conserved Domains (4) summary
      sd00044
      Location:137 → 161
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:18 → 550
      Adaptin_N; Adaptin N terminal region
      pfam07718
      Location:667 → 807
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:813 → 944
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform

    2. XM_008759661.4 → XP_008757883.1  coatomer subunit beta isoform X1

      See identical proteins and their annotated locations for XP_008757883.1

      UniProtKB/Swiss-Prot
      P23514
      UniProtKB/TrEMBL
      A6I896, A6I897
      Conserved Domains (4) summary
      sd00044
      Location:137 → 161
      HEAT; HEAT repeat [structural motif]
      pfam01602
      Location:18 → 550
      Adaptin_N; Adaptin N terminal region
      pfam07718
      Location:667 → 807
      Coatamer_beta_C; Coatomer beta C-terminal region
      pfam14806
      Location:813 → 944
      Coatomer_b_Cpla; Coatomer beta subunit appendage platform
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23514.1 GenPept UniProtKB/Swiss-Prot:P23514

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