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    H05L14.2 RING-type domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 172577, updated on 2-Nov-2024

    Summary

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    Official Symbol
    H05L14.2
    Official Full Name
    RING-type domain-containing protein
    Primary source
    WormBase:WBGene00010367
    Locus tag
    CELE_H05L14.2
    See related
    AllianceGenome:WB:WBGene00010367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process. Is expressed in gonad. [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See H05L14.2 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    13
    Sequence:
    Chromosome: I; NC_003279.8 (7984889..7993161)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein Neighboring gene RING-type domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane protein Neighboring gene Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. LIN-41 and OMA Ribonucleoprotein Complexes Mediate a Translational Repression-to-Activation Switch Controlling Oocyte Meiotic Maturation and the Oocyte-to-Embryo Transition in Caenorhabditis elegans. Tsukamoto T, et al. Genetics, 2017 Aug. PMID 28576864, Free PMC Article
    2. Functional identification of microRNA-centered complexes in C. elegans. Hebbar S, et al. Sci Rep, 2022 May 3. PMID 35504914, Free PMC Article
    3. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RING-type domain-containing protein
    NP_001337282.1
    • Confirmed by transcript evidence
    NP_001360419.1
    • Confirmed by transcript evidence
    NP_001368637.1
    • Confirmed by transcript evidence
    NP_001368638.1
    • Confirmed by transcript evidence
    NP_492199.4
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      7984889..7993161
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001373131.2 → NP_001360419.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUJ8
      Conserved Domains (5) summary
      TIGR02169
      Location:1181 → 1374
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam06003
      Location:337 → 472
      SMN; Survival motor neuron protein (SMN)
      cd00162
      Location:1553 → 1594
      RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
      pfam09770
      Location:408 → 530
      PAT1; Topoisomerase II-associated protein PAT1
      pfam13639
      Location:1553 → 1594
      zf-RING_2; Ring finger domain

    2. NM_059798.7 → NP_492199.4  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUI7
      Conserved Domains (5) summary
      TIGR02169
      Location:1285 → 1390
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam06003
      Location:351 → 486
      SMN; Survival motor neuron protein (SMN)
      cd00162
      Location:1569 → 1610
      RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
      pfam09770
      Location:422 → 544
      PAT1; Topoisomerase II-associated protein PAT1
      pfam13639
      Location:1569 → 1610
      zf-RING_2; Ring finger domain

    3. NM_001380787.1 → NP_001368637.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUG1
      Conserved Domains (3) summary
      PHA03378
      Location:389 → 530
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:1198 → 1389
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      pfam13639
      Location:1567 → 1608
      zf-RING_2; Ring finger domain

    4. NM_001380788.1 → NP_001368638.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUY1
      Conserved Domains (2) summary
      PHA03378
      Location:389 → 530
      PHA03378; EBNA-3B; Provisional
      COG1196
      Location:1198 → 1389
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    5. NM_001350372.5 → NP_001337282.1  RING-type domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1T5HUI4
      Conserved Domains (6) summary
      TIGR02169
      Location:1052 → 1245
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
      pfam06003
      Location:208 → 343
      SMN; Survival motor neuron protein (SMN)
      cd00162
      Location:1424 → 1465
      RING_Ubox; modified RING-H2 finger (C3H2C2D-type) [structural motif]
      pfam07964
      Location:408 → 632
      Red1; Rec10 / Red1
      pfam09770
      Location:279 → 401
      PAT1; Topoisomerase II-associated protein PAT1
      pfam13639
      Location:1424 → 1465
      zf-RING_2; Ring finger domain
    Nucleotide Protein
    Heading Accession and Version

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