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    ERG20 bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853272, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ERG20
    Official Full Name
    bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
    Primary source
    SGD:S000003703
    Locus tag
    YJL167W
    See related
    AllianceGenome:SGD:S000003703; FungiDB:YJL167W; VEuPathDB:YJL167W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    BOT3; FDS1; FPP1
    Summary
    Enables dimethylallyltranstransferase activity; geranyltranstransferase activity; and isopentenyl-diphosphate delta-isomerase activity. Involved in ergosterol biosynthetic process and farnesyl diphosphate biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in porokeratosis. Orthologous to human FDPS (farnesyl diphosphate synthase). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See ERG20 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (105014..106072)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Asg7p Neighboring gene histone methyltransferase SET2 Neighboring gene ubiquinol--cytochrome-c reductase subunit 8 Neighboring gene protein kinase HAL5

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. High-level production of linalool by engineered Saccharomyces cerevisiae harboring dual mevalonate pathways in mitochondria and cytoplasm. Zhang Y, et al. Enzyme Microb Technol, 2020 Mar. PMID 32044019
    2. The role of ERG20 gene (encoding yeast farnesyl diphosphate synthase) mutation in long dolichol formation. Molecular modeling of FPP synthase. Plochocka D, et al. Biochimie, 2000 Aug. PMID 11018290
    3. Efficient diterpene production in yeast by engineering Erg20p into a geranylgeranyl diphosphate synthase. Ignea C, et al. Metab Eng, 2015 Jan. PMID 25446975
    4. Increasing the intracellular isoprenoid pool in Saccharomyces cerevisiae by structural fine-tuning of a bifunctional farnesyl diphosphate synthase. Rubat S, et al. FEMS Yeast Res, 2017 Jun 1. PMID 28854674
    5. Biosynthesis of Taxadiene in Saccharomyces cerevisiae : selection of geranylgeranyl diphosphate synthase directed by a computer-aided docking strategy. Ding MZ, et al. PLoS One, 2014. PMID 25295588, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables dimethylallyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables dimethylallyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dimethylallyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables geranyltranstransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables geranyltranstransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables geranyltranstransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isopentenyl-diphosphate delta-isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables prenyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in ergosterol biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in geranyl diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoprenoid biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in isoprenoid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in vacuole NAS
    Non-traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase
    NP_012368.1
    • Farnesyl pyrophosphate synthetase; has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      105014..106072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181600.1 → NP_012368.1  TPA: bifunctional (2E,6E)-farnesyl diphosphate synthase/dimethylallyltranstransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012368.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VW20, P08524, P15495
      UniProtKB/TrEMBL
      A6ZQG5, B3LPV6, B5VL19, C7GRZ5, C8ZB52, G2WGK6
      Conserved Domains (1) summary
      pfam00348
      Location:38 → 305
      polyprenyl_synt; Polyprenyl synthetase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08524.2

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