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    Pdha1 pyruvate dehydrogenase E1 subunit alpha 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29554, updated on 28-Oct-2024

    Summary

    Official Symbol
    Pdha1provided by RGD
    Official Full Name
    pyruvate dehydrogenase E1 subunit alpha 1provided by RGD
    Primary source
    RGD:3286
    See related
    EnsemblRapid:ENSRNOG00000025383 AllianceGenome:RGD:3286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables pyruvate dehydrogenase (acetyl-transferring) activity. Involved in acetyl-CoA biosynthetic process from pyruvate. Part of pyruvate dehydrogenase complex. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHA1 (pyruvate dehydrogenase E1 subunit alpha 1). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in Heart (RPKM 2912.9), Muscle (RPKM 2115.2) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pdha1 in Genome Data Viewer
    Location:
    Xq14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (38509158..38522986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (34700481..34714309)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (37329779..37343410)

    Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA55 Neighboring gene late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 like 1 Neighboring gene mitogen-activated protein kinase kinase kinase 15 Neighboring gene ubiquitin-like 4A, pseudogene Neighboring gene SH3 domain-containing kinase-binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC94854, MGC114215

    Gene Ontology Provided by RGD

    Component Evidence Code Pubs
    part_of catalytic complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of pyruvate dehydrogenase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of pyruvate dehydrogenase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
    Names
    PDHE1-A type I
    pyruvate dehydrogenase (lipoamide) alpha 1
    pyruvate dehydrogenase E1 alpha 1 subunit
    pyruvate dehydrogenase E1alpha subunit
    pyruvate dehydrogenase alpha 1
    NP_001004072.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004072.2NP_001004072.2  pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial precursor

      See identical proteins and their annotated locations for NP_001004072.2

      Status: VALIDATED

      Source sequence(s)
      BC098897
      UniProtKB/Swiss-Prot
      P26284
      UniProtKB/TrEMBL
      Q4FZZ4
      Related
      ENSRNOP00000030279.8, ENSRNOT00000038352.8
      Conserved Domains (1) summary
      TIGR03182
      Location:58370
      PDH_E1_alph_y; pyruvate dehydrogenase E1 component, alpha subunit

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086039.1 Reference GRCr8

      Range
      38509158..38522986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)