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    PF3D7_0918000 glideosome-associated protein 50 [ Plasmodium falciparum 3D7 ]

    Gene ID: 813456, updated on 17-May-2024

    Summary

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    Gene symbol
    PF3D7_0918000
    Gene description
    glideosome-associated protein 50
    Primary source
    PlasmoDB:PF3D7_0918000
    Locus tag
    PF3D7_0918000
    See related
    VEuPathDB:PF3D7_0918000
    Gene type
    protein coding
    RNA name
    glideosome-associated protein 50
    RefSeq status
    PROVISIONAL
    Organism
    Plasmodium falciparum 3D7 (isolate: 3D7)
    Lineage
    Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
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    Genomic context

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    See PF3D7_0918000 in Genome Data Viewer
    Location:
    chromosome: 9
    Exon count:
    1
    Sequence:
    Chromosome: 9; NC_004330.2 (742494..743684, complement)

    Chromosome 9 - NC_004330.2Genomic Context describing neighboring genes Neighboring gene conserved Plasmodium protein, unknown function Neighboring gene heat shock protein 70 Neighboring gene cytochrome b5-like heme/steroid binding protein, putative Neighboring gene 50S ribosomal protein L3, apicoplast, putative

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_004330.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum. Bosch J, et al. J Struct Biol, 2012 Apr. PMID 22387043, Free PMC Article
    2. Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum. Yeoman JA, et al. Eukaryot Cell, 2011 Apr. PMID 21239623, Free PMC Article
    3. Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum. Müller IB, et al. Cell Microbiol, 2010 May 1. PMID 20070315
    4. Malaria parasites co-opt human factor H to prevent complement-mediated lysis in the mosquito midgut. Simon N, et al. Cell Host Microbe, 2013 Jan 16. PMID 23332154
    5. Origin, composition, organization and function of the inner membrane complex of Plasmodium falciparum gametocytes. Dearnley MK, et al. J Cell Sci, 2012 Apr 15. PMID 22328505

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. study describes the 1.7A resolution crystal structure of the soluble GAP50 domain
      Title: Crystal structure of GAP50, the anchor of the invasion machinery in the inner membrane complex of Plasmodium falciparum.
    2. Data show that C-terminally tagged PfGAP50-GFP can form a complex with endogenous copies of the linker protein PfGAP45 and the myosin A tail domain-interacting protein (MTIP).
      Title: Tracking Glideosome-associated protein 50 reveals the development and organization of the inner membrane complex of Plasmodium falciparum.
    3. Authors show that this acid phosphatase enzyme, formerly described as anchoring glideosome-associated protein 50 (GAP50), reveals a broad substrate profile with preference for di- and triphosphates at pH 5-7.
      Title: Secretion of an acid phosphatase provides a possible mechanism to acquire host nutrients by Plasmodium falciparum.
    4. This protein is an anchor for the gliding associated protein (GAP) complex of proteins. Commonly referred to as PfGAP50, this protein is present in Plasmodium falciparum merozoites and appears to have a role in erythrocyte invasion.
      Title: A conserved molecular motor drives cell invasion and gliding motility across malaria life cycle stages and other apicomplexan parasites.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GeneDB

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-membrane adaptor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell surface HDA PubMed 
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular vesicle HDA PubMed 
    located_in food vacuole HDA PubMed 
    located_in inner membrane pellicle complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glideosome-associated protein 50
    XP_001352051.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004330.2 Reference assembly

      Range
      742494..743684 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001352015.1 → XP_001352051.1  glideosome-associated protein 50 [Plasmodium falciparum 3D7]

      See identical proteins and their annotated locations for XP_001352051.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q8I2X3
      UniProtKB/TrEMBL
      A0A024V7X5, A0A024VS62, A0A024VVP5, A0A024WQT9, A0A024X828, A0A0L0CWD0, A0A0L1I8Q9, A0A0L7K8W0, A0A0L7M3D7, W4II87, W4IYK2, W7FW09, W7JYT7, W7JYU0
      Conserved Domains (1) summary
      PTZ00422
      Location:1 → 394
      PTZ00422; glideosome-associated protein 50; Provisional
    Nucleotide Protein
    Heading Accession and Version

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