Pnlip pancreatic lipase [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Pnlipprovided by RGD
Full Name: pancreatic lipaseprovided by RGD
Primary source: RGD:3360
See related: EnsemblRapid:ENSRNOG00000017725 AllianceGenome:RGD:3360
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: PANLI
Summary: Enables triacylglycerol lipase activity. Involved in post-embryonic development; response to lipid; and response to peptide hormone. Located in extracellular space. Used to study obesity. Orthologous to human PNLIP (pancreatic lipase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Restricted expression toward (RPKM 7974.3) See more
Orthologs: human mouse all
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Genomic context

Location:: 1q55

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (267760073..267797797)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (257774012..257811656)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (279798187..279811372)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pnlip encoding pancreatic lipase is a possible candidate for intramuscular fat accumulation QTL in OLETF rat.
Title: Pnlip encoding pancreatic lipase is a possible candidate for intramuscular fat accumulation QTL in OLETF rat.
Regulated expression of pancreatic triglyceride lipase after rat traumatic brain injury
Title: Regulated expression of pancreatic triglyceride lipase after rat traumatic brain injury.
Data show that pancreatic lipase and pancreatic lipase related protein 2 gene expression is regulated anticoordinately by the amount of dietary polyunsaturated fat starting as early as the preweanling phase of development.
Title: Pancreatic lipase and its related protein 2 are regulated by dietary polyunsaturated fat during the postnatal development of rats.
Pnlip is possible candidate for the Nidd6/of QTL in the OLETF rat
Title: Pnlip encoding pancreatic lipase is possible candidate for obesity QTL in the OLETF rat.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity	IEA Inferred from Electronic Annotation more info
enables lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables lipase activity	ISO Inferred from Sequence Orthology more info
enables lipoprotein lipase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phospholipase A1 activity	IBA Inferred from Biological aspect of Ancestor more info
enables triacylglycerol lipase activity	IDA Inferred from Direct Assay more info	PubMed
enables triacylglycerol lipase activity	IEA Inferred from Electronic Annotation more info
enables triacylglycerol lipase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in high-density lipoprotein particle remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in intestinal cholesterol absorption	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within intestinal cholesterol absorption	ISO Inferred from Sequence Orthology more info
involved_in lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of triglyceride lipase activity	ISO Inferred from Sequence Orthology more info
involved_in post-embryonic development	IDA Inferred from Direct Assay more info	PubMed
involved_in post-embryonic development	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in triglyceride catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pancreatic triacylglycerol lipase

Names: PL; pancreatic triglyceride lipase

NP_037293.2

EC 3.1.1.3

XP_038958090.1

EC 3.1.1.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013161.3 → NP_037293.2 pancreatic triacylglycerol lipase precursor

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P27657

UniProtKB/TrEMBL

A6JI64, G3V8A7

Related

ENSRNOP00000024065.4, ENSRNOT00000024065.7

Conserved Domains (2) summary

cd01759
Location:355 → 465

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:17 → 352

Lipase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

267760073..267797797

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039102162.2 → XP_038958090.1 pancreatic triacylglycerol lipase isoform X1

UniProtKB/Swiss-Prot

P27657

UniProtKB/TrEMBL

A6JI64, G3V8A7

Conserved Domains (2) summary

cd01759
Location:355 → 465

PLAT_PL; PLAT/LH2 domain of pancreatic triglyceride lipase. Lipases hydrolyze phospholipids and triglycerides to generate fatty acids for energy production or for storage and to release inositol phosphates that act as second messengers. The central role of ...

pfam00151
Location:17 → 352

Lipase