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    Dedd death effector domain-containing [ Mus musculus (house mouse) ]

    Gene ID: 21945, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Deddprovided by MGI
    Official Full Name
    death effector domain-containingprovided by MGI
    Primary source
    MGI:MGI:1333874
    See related
    Ensembl:ENSMUSG00000013973 AllianceGenome:MGI:1333874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    DEFT; KE05; FLDED1; Dedpro1; CASP8IP1
    Summary
    Enables DNA binding activity. Acts upstream of or within decidualization; extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of macromolecule metabolic process. Located in cytoplasm and nucleolus. Is expressed in central nervous system and retina. Orthologous to human DEDD (death effector domain containing). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 26.5), large intestine adult (RPKM 9.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dedd in Genome Data Viewer
    Location:
    1 H3; 1 79.34 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171152229..171170843)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171324661..171342501)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein L27, pseudogene 1 Neighboring gene predicted gene, 25151 Neighboring gene predicted gene, 20045 Neighboring gene STARR-positive B cell enhancer ABC_E2019 Neighboring gene nitrilase 1 Neighboring gene prefoldin 2 Neighboring gene STARR-positive B cell enhancer ABC_E4387 Neighboring gene kelch domain containing 9 Neighboring gene nectin cell adhesion molecule 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. [Cell cycle and cell sizing regulation via death effector domain]. Kurabe N, et al. Seikagaku, 2009 Jan. PMID 19260450
    2. The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability. Kurabe N, et al. Biochem Biophys Res Commun, 2010 Jan 22. PMID 20043882, Free PMC Article
    3. The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation. Kurabe N, et al. J Biol Chem, 2009 Feb 20. PMID 19106089, Free PMC Article
    4. DEDD, a novel death effector domain-containing protein, targeted to the nucleolus. Stegh AH, et al. EMBO J, 1998 Oct 15. PMID 9774341, Free PMC Article
    5. Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1. Arai S, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17283331, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In uteri of Dedd-/- mice, development of the decidual zone and the surrounding edema after embryonic implantation was defective. This was accompanied by disintegration of implantation site structure, leading to embryonic death before placentation.
      Title: Death effector domain-containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice.
    2. DEDD plays an important role in maintenance of the Akt protein level, which in consequence supports the efficient incorporation of glucose into skeletal muscles and adipose tissues.
      Title: The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.
    3. It regulates cell cycle and cell sizing. (review)
      Title: [Cell cycle and cell sizing regulation via death effector domain].
    4. The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.
      Title: The death effector domain-containing DEDD supports S6K1 activity via preventing Cdk1-dependent inhibitory phosphorylation.
    5. DEDD acts as a novel inhibitor of the mitotic Cdk1/cyclin B1 complex and is an impeder of cell mitosis, and its absence critically influences cell and body size via modulation of rRNA synthesis
      Title: Death-effector domain-containing protein DEDD is an inhibitor of mitotic Cdk1/cyclin B1.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within decidualization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in extrinsic apoptotic signaling pathway via death domain receptors IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    death effector domain-containing protein
    Names
    tumor necrosis factor (ligand) superfamily, member 19

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128609.2 → NP_001122081.1  death effector domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_001122081.1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Related
      ENSMUSP00000106931.2, ENSMUST00000111300.8
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    2. NM_001357550.2 → NP_001344479.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    3. NM_001357551.2 → NP_001344480.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    4. NM_001357552.2 → NP_001344481.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    5. NM_001357553.2 → NP_001344482.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Related
      ENSMUSP00000095075.2, ENSMUST00000097467.8
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    6. NM_001420632.1 → NP_001407561.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    7. NM_001420633.1 → NP_001407562.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    8. NM_001420634.1 → NP_001407563.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    9. NM_001420635.1 → NP_001407564.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    10. NM_001420636.1 → NP_001407565.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    11. NM_001420637.1 → NP_001407566.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    12. NM_001420638.1 → NP_001407567.1  death effector domain-containing protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC087229
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001

    13. NM_001420639.1 → NP_001407568.1  death effector domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087229

    14. NM_001420640.1 → NP_001407569.1  death effector domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087229

    15. NM_001420641.1 → NP_001407570.1  death effector domain-containing protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC087229

    16. NM_011615.4 → NP_035745.3  death effector domain-containing protein isoform 1

      See identical proteins and their annotated locations for NP_035745.3

      Status: VALIDATED

      Source sequence(s)
      AC087229
      Consensus CDS
      CCDS15490.1
      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Related
      ENSMUSP00000068419.5, ENSMUST00000064950.11
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      171152229..171170843
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496739.4 → XP_006496802.1  death effector domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_006496802.1

      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Related
      ENSMUSP00000106930.2, ENSMUST00000111299.8
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD

    2. XM_011238782.2 → XP_011237084.1  death effector domain-containing protein isoform X1

      See identical proteins and their annotated locations for XP_011237084.1

      UniProtKB/Swiss-Prot
      Q7TQH8, Q9R227, Q9Z1L3
      UniProtKB/TrEMBL
      Q3U001, Q3UYN3
      Conserved Domains (1) summary
      cd08790
      Location:22 → 118
      DED_DEDD; Death Effector Domain of DEDD
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z1L3.1 GenPept UniProtKB/Swiss-Prot:Q9Z1L3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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