SPP1 secreted phosphoprotein 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: SPP1provided by VGNC
Official Full Name: secreted phosphoprotein 1provided by VGNC
Primary source: VGNC:VGNC:93419
See related: Ensembl:ENSSSCG00000009216
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: Opn
Expression: Broad expression in kidney (RPKM 103.9), subcutaneous adipose (RPKM 47.9) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	8	NC_010450.4 (131077786..131085334, complement)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	8	NC_010450.3 (140307933..140315453, complement)

Chromosome 8 - NC_010450.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature.
Title: OPN binds alpha V integrin to promote endothelial progenitor cell incorporation into vasculature.
These data suggested that methylation in the OPN promoter plays a crucial role in the regulation of OPN expression that we found in cloned pigs genome.
Title: Osteoponin promoter controlled by DNA methylation: aberrant methylation in cloned porcine genome.
The striking breed differences between hyperprolific Large White and Meishanin pigs of secreted phospoprotein 1 expression in endometrium suggest that SPP1 may be associated with placental efficiency.
Title: Secreted phosphoprotein 1 expression in endometrium and placental tissues of hyperprolific large white and meishan gilts.
Microglia incubated in vitro with different concentrations (0.1 fM-1 nM) of recombinant osteopontin showed increased proliferation at 10 fM.
Title: Osteopontin alters the functional profile of porcine microglia in vitro.
results of this study reveal faster growth rate and differences in pig productivity according to genotypes of the SPP1 gene
Title: Porcine SPP1 gene polymorphism association with phenotypic traits in the Landrace × Jeju (Korea) Black pig F2 population.
Osteopontin could play an important role in the development of neointimal hyperplasia in venous conduits after coronary artery bypass grafting.
Title: Role of osteopontin in the development of neointimal hyperplasia in vein grafts.
A different MSSCP pattern was shown in osteopontin which indicates that mutation is located in promotor region; the A --> G transitions was identified in two positions -617 and -608
Title: The study of polymorphism within the promoter region of the osteopontin (OPN) gene in sows.
The 3' terminal end of the first intron of porcine SPP1 harbors a C/EBPbeta binding site and this binding site is negatively affected by the mutant G allele.
Title: Dual effect of a single nucleotide polymorphism in the first intron of the porcine secreted phosphoprotein 1 gene: allele-specific binding of C/EBP beta and activation of aberrant splicing.
Osteopontin is detected in the majority of germ cells and is involved in spermatogenesis in boar testis.
Title: Immunohistochemical study of osteopontin in boar testis.
osteopontin promotes pathologic mineralization via calcium pyrophosphate dihydrate crystal formation in articular cartilage.
Title: Osteopontin promotes pathologic mineralization in articular cartilage.

Submit: New GeneRIF Correction See all GeneRIFs (11)

General gene information

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Markers

OPN-2 (e-PCR)
- UniSTS:253862

OPN1 (e-PCR)
- UniSTS:253652

OPN (e-PCR), detects polymorphism
- UniSTS:251897

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info	PubMed
involved_in ossification	IEA Inferred from Electronic Annotation more info	PubMed
involved_in osteoblast differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of bone resorption	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: osteopontin

Names: SPP-1; bone sialoprotein 1; secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.