PLA2G1B phospholipase A2 group IB [Homo sapiens (human)] - Gene

Summary

Official Symbol: PLA2G1Bprovided by HGNC
Official Full Name: phospholipase A2 group IBprovided by HGNC
Primary source: HGNC:HGNC:9030
See related: Ensembl:ENSG00000170890 MIM:172410; AllianceGenome:HGNC:9030
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PLA2; PLA2A; PPLA2
Summary: This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response. [provided by RefSeq, Aug 2013]
Expression: Restricted expression toward pancreas (RPKM 9662.9) See more
Orthologs: mouse all
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Genomic context

Location:: 12q24.31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	12	NC_000012.12 (120322115..120327779, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	12	NC_060936.1 (120309295..120314955, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	12	NC_000012.11 (120759918..120765582, complement)

Chromosome 12 - NC_000012.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy.
Title: Microbial Protein Binding to gC1qR Drives PLA2G1B-Induced CD4 T-Cell Anergy.
Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis.
Title: Genetic analysis of pancreatic phospholipase A2 (PLA2G1B) in patients with chronic pancreatitis.
sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1(ser757) signaling pathway.
Title: sPLA2-IB and PLA2R mediate insufficient autophagy and contribute to podocyte injury in idiopathic membranous nephropathy by activation of the p38MAPK/mTOR/ULK1(ser757) signaling pathway.
sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy.
Title: sPLA2-IB Level Correlates with Hyperlipidemia and the Prognosis of Idiopathic Membranous Nephropathy.
PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
Title: PLA2G1B is involved in CD4 anergy and CD4 lymphopenia in HIV-infected patients.
sPLA2-IB was correlated with the level of proteinuria in membranous nephropathy patients suggesting to be a potential biomarker for monitoring disease severity and therapeutic effects of both primary membranous nephropathy and secondary membranous nephropathy.
Title: Serum secretory phospholipase A2 group IB correlates with the severity of membranous nephropathy.
The sPLA2 IB-PLA2R interaction stimulated podocyte apoptosis through activating ERK1/2 and cPLA2alpha and through increasing the podocyte AA content
Title: sPLA2 IB induces human podocyte apoptosis via the M-type phospholipase A2 receptor.
TNF-alpha-induced cPLA2 expression and PGE2 release were mediated through a Jak2/PDGFR/PI3K/Akt/p42/p44 MAPK/Elk-1 pathway in human lung epithelial cells.
Title: TNF-α induces cytosolic phospholipase A2 expression via Jak2/PDGFR-dependent Elk-1/p300 activation in human lung epithelial cells.
Exogenously added sPLA(2)-IB decreases phagocytosis of photoreceptor outer segments regardless of enzymatic activity.
Title: Diverse regulation of retinal pigment epithelium phagocytosis of photoreceptor outer segments by calcium-independent phospholipase A₂, group VIA and secretory phospholipase A₂, group IB.
Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 causes an activation of phospholipase A2, resulting in the increased release of arachidonic acid, which may sensitize the NMDA receptor	PubMed
	env	HIV-1 gp120 induces a specific phospholipase A2 (PLA2) activation in lymphocytes through binding to CD4, but this effect is not sufficient to accomplish virus/cell fusion	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:212655 (e-PCR)
- UniSTS:156171

G67590 (e-PCR)
- UniSTS:207033

G67591 (e-PCR)
- UniSTS:207034

NoName (e-PCR)
- UniSTS:483813

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables bile acid binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calcium-dependent phospholipase A2 activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipase A2 activity	IDA Inferred from Direct Assay more info	PubMed
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament organization	TAS Traceable Author Statement more info	PubMed
involved_in activation of phospholipase A2 activity	TAS Traceable Author Statement more info	PubMed
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in arachidonate secretion	TAS Traceable Author Statement more info	PubMed
involved_in cellular response to insulin stimulus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in fatty acid biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response in mucosa	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular signal transduction	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in leukotriene biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in lipid catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in neutrophil chemotaxis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in neutrophil mediated immunity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in phosphatidylcholine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylcholine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylglycerol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylglycerol metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of MAP kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of calcium ion transport into cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of positive regulation of interleukin-8 production	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of podocyte apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in regulation of D-glucose import	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in signal transduction	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: phospholipase A2

Names: phosphatidylcholine 2-acylhydrolase 1B; phospholipase A2, group IB (pancreas)

NP_000919.1

EC 3.1.1.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.