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    CDC42BPB CDC42 binding protein kinase beta [ Equus caballus (horse) ]

    Gene ID: 100058888, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDC42BPBprovided by VGNC
    Official Full Name
    CDC42 binding protein kinase betaprovided by VGNC
    Primary source
    VGNC:VGNC:16297
    See related
    Ensembl:ENSECAG00000021040
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: 24
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 24 NC_009167.3 (44948358..45081793, complement)

    Chromosome 24 - NC_009167.3Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 3 Neighboring gene amnion associated transmembrane protein Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3 like 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009167.3 Chromosome 24 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009167.3 Reference EquCab3.0 Primary Assembly

      Range
      44948358..45081793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023628441.1 → XP_023484209.1  serine/threonine-protein kinase MRCK beta isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GUN0, A0A9L0R1K8
      Related
      ENSECAP00000024410.1, ENSECAT00000055615.2
      Conserved Domains (7) summary
      smart00285
      Location:1600 → 1627
      PBD; P21-Rho-binding domain
      COG0419
      Location:439 → 955
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1043 → 1092
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1102 → 1236
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1262 → 1527
      CNH; CNH domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    2. XM_023628443.1 → XP_023484211.1  serine/threonine-protein kinase MRCK beta isoform X3

      UniProtKB/TrEMBL
      A0A9L0RMC1
      Conserved Domains (7) summary
      smart00285
      Location:1506 → 1533
      PBD; P21-Rho-binding domain
      COG0419
      Location:345 → 861
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:949 → 998
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1008 → 1142
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:1168 → 1433
      CNH; CNH domain
      pfam15796
      Location:434 → 512
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl21453
      Location:1 → 317
      PKc_like; Protein Kinases, catalytic domain

    3. XM_023628442.1 → XP_023484210.1  serine/threonine-protein kinase MRCK beta isoform X2

      UniProtKB/TrEMBL
      A0A9L0R1K8
      Conserved Domains (7) summary
      smart00285
      Location:1584 → 1611
      PBD; P21-Rho-binding domain
      COG0419
      Location:439 → 955
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1027 → 1076
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1086 → 1220
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1246 → 1511
      CNH; CNH domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. XR_002803706.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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