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    CDC42BPB CDC42 binding protein kinase beta [ Equus caballus (horse) ]

    Gene ID: 100058888, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CDC42BPBprovided by VGNC
    Official Full Name
    CDC42 binding protein kinase betaprovided by VGNC
    Primary source
    VGNC:VGNC:16297
    See related
    Ensembl:ENSECAG00000021040
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Equus caballus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Perissodactyla; Equidae; Equus
    Orthologs
    human mouse all
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    Genomic context

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    See CDC42BPB in Genome Data Viewer
    Location:
    chromosome: 24
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2024_08 current EquCab3.0 (GCF_002863925.1) 24 NC_009167.3 (44948358..45081793, complement)

    Chromosome 24 - NC_009167.3Genomic Context describing neighboring genes Neighboring gene TNF receptor associated factor 3 Neighboring gene amnion associated transmembrane protein Neighboring gene LBH domain containing 2 Neighboring gene exocyst complex component 3 like 4

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_009167.3 Chromosome 24 Reference EquCab3.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Annotation of the Protein Coding Regions of the Equine Genome. Hestand MS, et al. PLoS One, 2015. PMID 26107351, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_002863925.1-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference EquCab3.0 Primary Assembly

    Genomic

    1. NC_009167.3 Reference EquCab3.0 Primary Assembly

      Range
      44948358..45081793 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_023628441.1 → XP_023484209.1  serine/threonine-protein kinase MRCK beta isoform X1

      UniProtKB/TrEMBL
      A0A3Q2GUN0, A0A9L0R1K8
      Related
      ENSECAP00000024410.1, ENSECAT00000055615.2
      Conserved Domains (7) summary
      smart00285
      Location:1600 → 1627
      PBD; P21-Rho-binding domain
      COG0419
      Location:439 → 955
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1043 → 1092
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1102 → 1236
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1262 → 1527
      CNH; CNH domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    2. XM_023628443.1 → XP_023484211.1  serine/threonine-protein kinase MRCK beta isoform X3

      UniProtKB/TrEMBL
      A0A9L0RMC1
      Conserved Domains (7) summary
      smart00285
      Location:1506 → 1533
      PBD; P21-Rho-binding domain
      COG0419
      Location:345 → 861
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:949 → 998
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1008 → 1142
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:1168 → 1433
      CNH; CNH domain
      pfam15796
      Location:434 → 512
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl21453
      Location:1 → 317
      PKc_like; Protein Kinases, catalytic domain

    3. XM_023628442.1 → XP_023484210.1  serine/threonine-protein kinase MRCK beta isoform X2

      UniProtKB/TrEMBL
      A0A9L0R1K8
      Conserved Domains (7) summary
      smart00285
      Location:1584 → 1611
      PBD; P21-Rho-binding domain
      COG0419
      Location:439 → 955
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1027 → 1076
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1086 → 1220
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1246 → 1511
      CNH; CNH domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. XR_002803706.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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