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    Mrpl45 mitochondrial ribosomal protein L45 [ Mus musculus (house mouse) ]

    Gene ID: 67036, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrpl45provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L45provided by MGI
    Primary source
    MGI:MGI:1914286
    See related
    Ensembl:ENSMUSG00000018882 AllianceGenome:MGI:1914286
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2600005P05Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in mitochondrial translation. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human MRPL45 (mitochondrial ribosomal protein L45). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in heart adult (RPKM 11.8), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl45 in Genome Data Viewer
    Location:
    11 D; 11 60.95 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (97205749..97220746)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (97314923..97329920)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene aminopeptidase puromycin sensitive Neighboring gene predicted gene 11592 Neighboring gene STARR-seq mESC enhancer starr_30592 Neighboring gene STARR-seq mESC enhancer starr_30593 Neighboring gene predicted gene, 31005 Neighboring gene STARR-seq mESC enhancer starr_30594 Neighboring gene STARR-seq mESC enhancer starr_30595 Neighboring gene predicted gene, 53647 Neighboring gene G protein-coupled receptor 179 Neighboring gene suppressor of cytokine signaling 7

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cardiac deletion of Smyd2 is dispensable for mouse heart development. Diehl F, et al. PLoS One, 2010 Mar 17. PMID 20305823, Free PMC Article
    2. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    3. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    4. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846
    5. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of ribosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitochondrial translation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL45
    Names
    39S ribosomal protein L45, mitochondrial
    L45mt
    MRP-L45

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025927.4 → NP_080203.1  large ribosomal subunit protein mL45

      See identical proteins and their annotated locations for NP_080203.1

      Status: VALIDATED

      Source sequence(s)
      AK011163, AL596088, BY263659
      Consensus CDS
      CCDS25318.1
      UniProtKB/Swiss-Prot
      Q3TZL8, Q8VDW2, Q9D0Q7
      UniProtKB/TrEMBL
      Q9CSZ8
      Related
      ENSMUSP00000019026.4, ENSMUST00000019026.10
      Conserved Domains (1) summary
      pfam04280
      Location:119 → 266
      Tim44; Tim44-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      97205749..97220746
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017314713.2 → XP_017170202.1  large ribosomal subunit protein mL45 isoform X1

      Conserved Domains (1) summary
      smart00978
      Location:119 → 322
      Tim44; Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D0Q7.1 GenPept UniProtKB/Swiss-Prot:Q9D0Q7

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