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    Klc4 kinesin light chain 4 [ Mus musculus (house mouse) ]

    Gene ID: 74764, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Klc4provided by MGI
    Official Full Name
    kinesin light chain 4provided by MGI
    Primary source
    MGI:MGI:1922014
    See related
    Ensembl:ENSMUSG00000003546 AllianceGenome:MGI:1922014
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Knsl8; 1200014P03Rik
    Summary
    Predicted to enable kinesin binding activity. Predicted to be involved in microtubule-based movement. Predicted to be located in microtubule. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm. Orthologous to human KLC4 (kinesin light chain 4). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Broad expression in small intestine adult (RPKM 54.4), duodenum adult (RPKM 41.8) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Klc4 in Genome Data Viewer
    Location:
    17 C; 17 22.9 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (46941550..46957115, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (46630624..46646189, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E7535 Neighboring gene microRNA 6976 Neighboring gene serum response factor Neighboring gene PTK7 protein tyrosine kinase 7 Neighboring gene VISTA enhancer mm1620 Neighboring gene STARR-seq mESC enhancer starr_42674 Neighboring gene STARR-seq mESC enhancer starr_42675 Neighboring gene STARR-positive B cell enhancer ABC_E10957 Neighboring gene STARR-positive B cell enhancer ABC_E7536 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene cullin 7 Neighboring gene STARR-seq mESC enhancer starr_42676 Neighboring gene ribosomal RNA processing 36

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The ciliary rootlet interacts with kinesin light chains and may provide a scaffold for kinesin-1 vesicular cargos. Yang J, et al. Exp Cell Res, 2005 Oct 1. PMID 16018997
    2. Novel protein interactions with endoglin and activin receptor-like kinase 1: potential role in vascular networks. Xu G, et al. Mol Cell Proteomics, 2014 Feb. PMID 24319055, Free PMC Article
    3. Identification of 14-3-3epsilon substrates from embryonic murine brain. Ballif BA, et al. J Proteome Res, 2006 Sep. PMID 16944949
    4. Construction of a multi-functional cDNA library specific for mouse pancreatic islets and its application to microarray. Nishimura M, et al. DNA Res, 2004 Oct 31. PMID 15747579
    5. Matrix-screening reveals a vast potential for direct protein-protein interactions among RNA binding proteins. Lang B, et al. Nucleic Acids Res, 2021 Jul 9. PMID 34133714, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables kinesin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of kinesin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinesin light chain 4
    Names
    KLC 4
    kinesin-like 8
    kinesin-like protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357130.2 → NP_001344059.1  kinesin light chain 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165445
      Consensus CDS
      CCDS28832.1
      UniProtKB/Swiss-Prot
      Q3TCC5, Q9DBS5
      Related
      ENSMUSP00000156564.2, ENSMUST00000233974.2
      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    2. NM_001432584.1 → NP_001419513.1  kinesin light chain 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165445
      UniProtKB/Swiss-Prot
      Q3TCC5, Q9DBS5

    3. NM_001432585.1 → NP_001419514.1  kinesin light chain 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC165445
      UniProtKB/Swiss-Prot
      Q3TCC5, Q9DBS5

    4. NM_001432586.1 → NP_001419515.1  kinesin light chain 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165445

    5. NM_001432587.1 → NP_001419516.1  kinesin light chain 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165445

    6. NM_001432588.1 → NP_001419517.1  kinesin light chain 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC165445

    7. NM_029091.4 → NP_083367.1  kinesin light chain 4 isoform 1

      See identical proteins and their annotated locations for NP_083367.1

      Status: VALIDATED

      Source sequence(s)
      AC165445
      Consensus CDS
      CCDS28832.1
      UniProtKB/Swiss-Prot
      Q3TCC5, Q9DBS5
      Related
      ENSMUSP00000003642.7, ENSMUST00000003642.7
      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      46941550..46957115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525044.4 → XP_006525107.1  kinesin light chain 4 isoform X2

      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    2. XM_036160817.1 → XP_036016710.1  kinesin light chain 4 isoform X2

      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat

    3. XM_011246689.3 → XP_011244991.1  kinesin light chain 4 isoform X1

      Conserved Domains (3) summary
      TIGR02168
      Location:33 → 148
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      sd00006
      Location:295 → 323
      TPR; TPR repeat [structural motif]
      pfam13424
      Location:294 → 369
      TPR_12; Tetratricopeptide repeat
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DBS5.1 GenPept UniProtKB/Swiss-Prot:Q9DBS5

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