Stmn1 stathmin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stmn1provided by RGD
Official Full Name: stathmin 1provided by RGD
Primary source: RGD:2992
See related: EnsemblRapid:ENSRNOG00000016810 AllianceGenome:RGD:2992
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SMN; OP18; PP17; PP19; PR22; Lap18; prosolin
Summary: Predicted to enable tubulin binding activity. Predicted to be involved in several processes, including establishment of skin barrier; negative regulation of signal transduction; and regulation of cytoskeleton organization. Predicted to act upstream of or within several processes, including axonogenesis; mitotic spindle organization; and negative regulation of microtubule polymerization. Predicted to be located in cytosol and membrane. Predicted to be active in cytoplasm and neuron projection. Orthologous to human STMN1 (stathmin 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 2149.6), Brain (RPKM 1909.3) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (151964308..151970843)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (146680757..146687154)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (152680412..152686807)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats.
Title: Stathmin Regulates Spatiotemporal Variation in the Memory Loop in Single-Prolonged Stress Rats.
Stathmin is enriched in the developing corticospinal tract
Title: Stathmin is enriched in the developing corticospinal tract.
Stathmin therefore mediates hepatocyte resistance to death from oxidative stress by down regulating JNK and maintaining mitochondrial integrity
Title: Stathmin mediates hepatocyte resistance to death from oxidative stress by down regulating JNK.
JNK- and PKA-mediated STMN Ser-38 and Ser-63 phosphorylation are required to preserve interphase microtubules in response to hyperosmotic stress.
Title: cAMP-dependent protein kinase and c-Jun N-terminal kinase mediate stathmin phosphorylation for the maintenance of interphase microtubules during osmotic stress.
Stathmin 1 expression was decreased in the experimental animals from 1 to 14 days postseizure and then significantly increased at Days 30 and 60.
Title: Abnormal expression of stathmin 1 in brain tissue of patients with intractable temporal lobe epilepsy and a rat model.
role of stathmin 1 in FcRI-mediated activation of cells of mast cell lineage and might shed light on the diverse response of these cells to IgE or IgE plus antigen.
Title: A novel insight to the functional role of Stathmin 1 in IgE-mediated activation of RBL-2H3 cells.
Stathmin 1 is involved in the neuroprotective effect of pituitary adenylate cyclase-activating polypeptide (PACAP) in PC12 cells subjected to serum starvation.
Title: Involvement of stathmin 1 in the neurotrophic effects of PACAP in PC12 cells.
Stathmin expression increases in the uterus when stimulated by embryo implantation and decidualization and may play a role in the early stages of pregnancy.
Title: Enhanced expression of uterine stathmin during the process of implantation and decidualization in rats.
Sustained stathmin levels in differentiating oligodendrocytes, because of overexpression, resulted in enhanced apoptotic susceptibility.
Title: Expression of stathmin, a developmentally controlled cytoskeleton-regulating molecule, in demyelinating disorders.
role for stathmin in the migration of newborn neurons in the adult brain
Title: Proteomic and immunochemical characterization of a role for stathmin in adult neurogenesis.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94569 (e-PCR)
- UniSTS:119817

STMN1 (e-PCR)
- UniSTS:513698

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within axonogenesis	ISO Inferred from Sequence Orthology more info
involved_in establishment of skin barrier	ISO Inferred from Sequence Orthology more info
involved_in hepatocyte growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	TAS Traceable Author Statement more info	PubMed
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in microtubule depolymerization	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within mitotic spindle organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of Rho protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of microtubule polymerization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stress fiber assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of thrombin-activated receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in regulation of microtubule polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of microtubule polymerization or depolymerization	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule polymerization or depolymerization	ISO Inferred from Sequence Orthology more info
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: stathmin

Names: leukemia-associated phosphoprotein p18; metablastin; oncoprotein 18; phosphoprotein p19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001429881.1 → NP_001416810.1 stathmin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P13668

UniProtKB/TrEMBL

A6IT24
NM_001429882.1 → NP_001416811.1 stathmin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P13668

UniProtKB/TrEMBL

A6IT24
NM_001429883.1 → NP_001416812.1 stathmin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P13668

UniProtKB/TrEMBL

A6IT24
NM_001429884.1 → NP_001416813.1 stathmin

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P13668

UniProtKB/TrEMBL

A6IT24
NM_017166.3 → NP_058862.1 stathmin

See identical proteins and their annotated locations for NP_058862.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P13668

UniProtKB/TrEMBL

A0A8I5ZX99, A0A8L2QYX2, A6IT24

Conserved Domains (1) summary

pfam00836
Location:5 → 140

Stathmin; Stathmin family