RGS20 regulator of G protein signaling 20 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RGS20provided by HGNC
Official Full Name: regulator of G protein signaling 20provided by HGNC
Primary source: HGNC:HGNC:14600
See related: Ensembl:ENSG00000147509 MIM:607193; AllianceGenome:HGNC:14600
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RGSZ1; ZGAP1; gz-GAP; g(z)GAP
Summary: The protein encoded by this gene belongs to the family of regulator of G protein signaling (RGS) proteins, which are regulatory and structural components of G protein-coupled receptor complexes. RGS proteins inhibit signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound forms. This protein selectively binds to G(z)-alpha and G(alpha)-i2 subunits, and regulates their signaling activities. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
Expression: Biased expression in brain (RPKM 2.5), thyroid (RPKM 0.6) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8q11.23

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (53851795..53959303)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (54229188..54336699)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (54764355..54871863)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RGS20 acted as an oncogene in bladder cancer.
Title: Regulator of G protein signaling 20 promotes proliferation and migration in bladder cancer via NF-κB signaling.
1H, 13C and 15N resonance assignments of human RGSZ1.
Title: 1H, 13C and 15N resonance assignments of human RGSZ1.
NEAT1 silencing also inhibited tumor growth in vivo. Collectively, we revealed that the NEAT1/miR365/RGS20 axis may be a novel mechanism or therapeutic strategy for OSCC treatment.
Title: lncRNA NEAT1 promotes cell proliferation and invasion by regulating miR‑365/RGS20 in oral squamous cell carcinoma.
Data suggest that Gpr176 (G-protein coupled receptor 176) is an SCN-(suprachiasmatic nucleus-)enriched orphan GPCR (G-protein-coupled receptor) that sets the pace of circadian behavior; a unique cAMP-repressing G-protein subclass Gz is required for the activity of Gpr176. [REVIEW]
Title: G-protein-coupled receptor signaling through Gpr176, Gz, and RGS16 tunes time in the center of the circadian clock [Review].
These results suggest that the expression of RGS20 may promote metastasis of tumor cells.
Title: Regulator of G protein signaling 20 enhances cancer cell aggregation, migration, invasion and adhesion.
Findings suggest that high regulator of G protein signaling 20 (RGS20) expression is associated with unfavorable survival in triple-negative breast cancer (TNBC).
Title: Regulator of G protein signaling 20 correlates with clinicopathological features and prognosis in triple-negative breast cancer.
Observational study of gene-disease association. (HuGE Navigator)
Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
Title: Identification of hypertension-susceptibility genes and pathways by a systemic multiple candidate gene approach: the millennium genome project for hypertension.
The major function of PKCI-1 is to modulate mu opioid receptor signaling pathway along with RGSZ1, rather than directly mediating the Galphaz RGSZ1 interaction.
Title: RGSZ1 interacts with protein kinase C interacting protein PKCI-1 and modulates mu opioid receptor signaling.
provide new evidence that RGSZ1 interacts not only with Galpha(z,) but also with Galpha(i), as supported by in vitro binding assays and functional studies
Title: Regulator of G protein signaling Z1 (RGSZ1) interacts with Galpha i subunits and regulates Galpha i-mediated cell signaling.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH45828 (e-PCR)
- UniSTS:52021

RH102850 (e-PCR)
- UniSTS:97184

RGS20_782 (e-PCR)
- UniSTS:277667

SHGC-148290 (e-PCR)
- UniSTS:172973

G60566 (e-PCR)
- UniSTS:137672

D8S1737 (e-PCR), detects polymorphism
- UniSTS:74461

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables GTPase activator activity	TAS Traceable Author Statement more info	PubMed
enables GTPase activity	TAS Traceable Author Statement more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info
involved_in negative regulation of signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of G protein-coupled receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in response to amphetamine	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IMP Inferred from Mutant Phenotype more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	TAS Traceable Author Statement more info
located_in trans-Golgi network	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: regulator of G-protein signaling 20

Names: gz-selective GTPase-activating protein; regulator of G-protein signaling Z1; regulator of G-protein signalling 20; regulator of Gz-selective protein signaling 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001286673.2 → NP_001273602.1 regulator of G-protein signaling 20 isoform c

See identical proteins and their annotated locations for NP_001273602.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the 5' coding region comapred to variant 1. The encoded isoform (c) is shorter than isoform a.

Source sequence(s)

AC100821, AC113194, AF366054

Consensus CDS

CCDS69482.1

UniProtKB/Swiss-Prot

O76081

Related

ENSP00000344630.6, ENST00000344277.10

Conserved Domains (1) summary

cd08746
Location:106 → 261

RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
NM_001286674.2 → NP_001273603.1 regulator of G-protein signaling 20 isoform d

See identical proteins and their annotated locations for NP_001273603.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) lacks three in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (d) is shorter and has a distinct N-terminus compared to isoform a.

Source sequence(s)

AC100821, AC113194, AF366056

UniProtKB/Swiss-Prot

O76081

Conserved Domains (1) summary

cl02565
Location:12 → 140

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_001286675.2 → NP_001273604.1 regulator of G-protein signaling 20 isoform e

See identical proteins and their annotated locations for NP_001273604.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) lacks two in-frame exons in the central coding region which results in the use of an alternate start codon compared to variant 1. The encoded isoform (e) is shorter than isoform a.

Source sequence(s)

AC100821, AC113194, AF366055

UniProtKB/Swiss-Prot

O76081

Conserved Domains (1) summary

cl02565
Location:11 → 168

RGS; Regulator of G protein signaling (RGS) domain superfamily
NM_003702.5 → NP_003693.2 regulator of G-protein signaling 20 isoform b

See identical proteins and their annotated locations for NP_003693.2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR and 5' coding region compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.

Source sequence(s)

AC100821, AC113194

Consensus CDS

CCDS6156.1

UniProtKB/TrEMBL

H9NIM5

Related

ENSP00000276500.4, ENST00000276500.5

Conserved Domains (1) summary

cd08746
Location:74 → 229

RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein
NM_170587.4 → NP_733466.1 regulator of G-protein signaling 20 isoform a

See identical proteins and their annotated locations for NP_733466.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AC100821, AC113194, AY046538

Consensus CDS

CCDS6155.1

UniProtKB/Swiss-Prot

O76081, Q96BG9

Related

ENSP00000297313.3, ENST00000297313.8

Conserved Domains (1) summary

cd08746
Location:221 → 376

RGS_RGS20; Regulator of G protein signaling (RGS) domain found in the RGS20 protein

RNA

NR_104578.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (6) uses an alternate exon structure compared to variant 1 but does share exon structure with variant 2. This variant is represented as non-coding because it lacks the entire coding region found in variant 1.

Source sequence(s)

BC054867

Related

ENST00000523064.1
NR_104579.2 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (7) has multiple differences compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AC100821, AC113194, AK094503

Related

ENST00000522225.5