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    cel.2 carboxyl ester lipase, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 565117, updated on 18-Sep-2024

    Summary

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    Official Symbol
    cel.2provided by ZNC
    Official Full Name
    carboxyl ester lipase, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-061110-10
    See related
    Ensembl:ENSDARG00000029822 AllianceGenome:ZFIN:ZDB-GENE-061110-10
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    cell; celip; basal.2; zgc:112377; zgc:153861
    Summary
    Predicted to enable lipase activity; neurexin family protein binding activity; and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to act upstream of or within lipid metabolic process. Predicted to be active in cell surface and synapse. Predicted to be integral component of postsynaptic specialization membrane. Human ortholog(s) of this gene implicated in lipomatosis; maturity-onset diabetes of the young type 8; type 1 diabetes mellitus; and type 2 diabetes mellitus. Orthologous to human CEL (carboxyl ester lipase). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See cel.2 in Genome Data Viewer
    Location:
    chromosome: 21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (11385024..11393994)
    105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (11292405..11318735)

    Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene zgc:162472 Neighboring gene general transcription factor IIIC, polypeptide 5 Neighboring gene carboxyl ester lipase, tandem duplicate 1 Neighboring gene zgc:92275

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular cloning and characterization of an atypical butyrylcholinesterase-like protein in zebrafish. Tan KS, et al. Comp Biochem Physiol B Biochem Mol Biol, 2021 Aug-Sep. PMID 33662568
    2. Carboxyl ester lipase is highly conserved in utilizing maternal supplied lipids during early development of zebrafish and human. Qiu Y, et al. Biochim Biophys Acta Mol Cell Biol Lipids, 2020 Jun. PMID 32061751
    3. Zebrafish acetylcholinesterase is encoded by a single gene localized on linkage group 7. Gene structure and polymorphism; molecular forms and expression pattern during development. Bertrand C, et al. J Biol Chem, 2001 Jan 5. PMID 11016933
    4. Systems pharmacology of adiposity reveals inhibition of EP300 as a common therapeutic mechanism of caloric restriction and resveratrol for obesity. Nishimura Y, et al. Front Pharmacol, 2015. PMID 26441656, Free PMC Article
    5. Comparative Study of the Molecular Characterization, Evolution, and Structure Modeling of Digestive Lipase Genes Reveals the Different Evolutionary Selection Between Mammals and Fishes. Tang SL, et al. Front Genet, 2022. PMID 35991544, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112377

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables retinyl-palmitate esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol ester esterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables triacylglycerol lipase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in ceramide catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pancreatic juice secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    bile salt-activated lipase
    Names
    carboxyl ester lipase, like
    danio-celip
    NP_001020344.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025173.2 → NP_001020344.2  bile salt-activated lipase precursor

      Status: VALIDATED

      Source sequence(s)
      BX005379, FP015918
      UniProtKB/TrEMBL
      A0A8M9PQY7
      Related
      ENSDARP00000040597.5, ENSDART00000040598.6
      Conserved Domains (1) summary
      pfam00135
      Location:26 → 539
      COesterase; Carboxylesterase family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007132.7 Reference GRCz11 Primary Assembly

      Range
      11385024..11393994
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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