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    F9 coagulation factor IX [ Desmodus rotundus (common vampire bat) ]

    Gene ID: 112300060, updated on 30-Mar-2024

    Summary

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    Gene symbol
    F9
    Gene description
    coagulation factor IX
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Desmodus rotundus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Chiroptera; Yangochiroptera; Phyllostomidae; Desmodontinae; Desmodus
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    chromosome: X
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2023_02 current HLdesRot8A (GCF_022682495.1) X NC_071400.1 (14510214..14542536, complement)
    101 previous assembly ASM294091v2 (GCF_002940915.1) Unplaced Scaffold NW_020090905.1 (586382..618151)

    Chromosome X - NC_071400.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L12-like Neighboring gene MCF.2 cell line derived transforming sequence Neighboring gene uridine-cytidine kinase 2-like Neighboring gene small nucleolar RNA SNORA3/SNORA45 family

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in blood coagulation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in zymogen activation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    coagulation factor IX

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_022682495.1-RS_2023_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference HLdesRot8A Primary Assembly

    Genomic

    1. NC_071400.1 Reference HLdesRot8A Primary Assembly

      Range
      14510214..14542536 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_045191297.2 → XP_045047232.1  coagulation factor IX isoform X2

    2. XM_024555248.3 → XP_024411016.1  coagulation factor IX isoform X1

      Conserved Domains (4) summary
      smart00069
      Location:28 → 92
      GLA; Domain containing Gla (gamma-carboxyglutamate) residues
      cd00054
      Location:93 → 129
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      cd00190
      Location:228 → 458
      Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
      pfam14670
      Location:134 → 170
      FXa_inhibition; Coagulation Factor Xa inhibitory site
    Nucleotide Protein
    Heading Accession and Version

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