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    Tle3 transducin-like enhancer of split 3 [ Mus musculus (house mouse) ]

    Gene ID: 21887, updated on 28-Oct-2024

    Summary

    Official Symbol
    Tle3provided by MGI
    Official Full Name
    transducin-like enhancer of split 3provided by MGI
    Primary source
    MGI:MGI:104634
    See related
    Ensembl:ENSMUSG00000032280 AllianceGenome:MGI:104634
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESG; Grg3a; Grg3b; mKIAA1547; 2610103N05Rik
    Summary
    Predicted to enable transcription corepressor activity. Involved in negative regulation of cold-induced thermogenesis. Predicted to be located in nucleoplasm. Predicted to be part of beta-catenin-TCF complex. Predicted to be active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and sensory organ. Orthologous to human TLE3 (TLE family member 3, transcriptional corepressor). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 52.0), thymus adult (RPKM 46.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Tle3 in Genome Data Viewer
    Location:
    9 B; 9 33.27 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (61279608..61325779)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (61372326..61418497)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E135 Neighboring gene STARR-positive B cell enhancer ABC_E712 Neighboring gene predicted gene, 34157 Neighboring gene predicted gene 10655 Neighboring gene STARR-seq mESC enhancer starr_24345 Neighboring gene STARR-seq mESC enhancer starr_24346 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:61274881-61275167 Neighboring gene STARR-positive B cell enhancer mm9_chr9:61279693-61279993 Neighboring gene predicted gene, 34322 Neighboring gene STARR-seq mESC enhancer starr_24348 Neighboring gene STARR-positive B cell enhancer ABC_E8294 Neighboring gene predicted gene, 34424

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cold-induced thermogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of beta-catenin-TCF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    transducin-like enhancer protein 3
    Names
    grg-3
    transducin-like enhancer of split 3, homolog of Drosophila E(spl)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083927.1NP_001077396.1  transducin-like enhancer protein 3 isoform 1

      See identical proteins and their annotated locations for NP_001077396.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      AC126672, BB611599, BC056465, BX630781
      Consensus CDS
      CCDS52826.1
      UniProtKB/TrEMBL
      E0CXS2
      Related
      ENSMUSP00000124131.2, ENSMUST00000160882.8
      Conserved Domains (4) summary
      cd00200
      Location:494779
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261482
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:499538
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. NM_001083928.1NP_001077397.1  transducin-like enhancer protein 3 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC126672, AK122524, BB611599, BQ770333, BX630781
      Consensus CDS
      CCDS52824.1
      UniProtKB/TrEMBL
      E0CXS2, F8WIE2
      Related
      ENSMUSP00000034820.10, ENSMUST00000034820.16
      Conserved Domains (4) summary
      cd00200
      Location:476761
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251464
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:481520
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    3. NM_009389.2NP_033415.2  transducin-like enhancer protein 3 isoform 2

      See identical proteins and their annotated locations for NP_033415.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the same N- and C-termini compared to isoform 1.
      Source sequence(s)
      AC126672, AK031322, AK122524, BB611599, BQ770333, BX630781
      Consensus CDS
      CCDS52825.1
      UniProtKB/Swiss-Prot
      Q08122, Q6PHP0, Q923A4
      UniProtKB/TrEMBL
      E0CXS2
      Related
      ENSMUSP00000124173.2, ENSMUST00000162973.8
      Conserved Domains (4) summary
      cd00200
      Location:484769
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251472
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:489528
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9133
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      61279608..61325779
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511026.4XP_006511089.1  transducin-like enhancer protein 3 isoform X4

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:489774
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261477
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:494533
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    2. XM_006511025.4XP_006511088.1  transducin-like enhancer protein 3 isoform X2

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:491776
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261479
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:496535
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    3. XM_006511027.4XP_006511090.1  transducin-like enhancer protein 3 isoform X5

      UniProtKB/TrEMBL
      E0CXS2
      Related
      ENSMUSP00000124150.2, ENSMUST00000162127.2
      Conserved Domains (4) summary
      cd00200
      Location:486771
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:261474
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:491530
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9143
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    4. XM_017313277.2XP_017168766.1  transducin-like enhancer protein 3 isoform X1

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:493778
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:260481
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:498537
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    5. XM_036154839.1XP_036010732.1  transducin-like enhancer protein 3 isoform X3

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:490775
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:260478
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:495534
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9142
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    6. XM_006511029.4XP_006511092.1  transducin-like enhancer protein 3 isoform X9

      UniProtKB/TrEMBL
      E0CXS2, E0CXS9
      Related
      ENSMUSP00000125032.2, ENSMUST00000159050.8
      Conserved Domains (4) summary
      cd00200
      Location:479764
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251467
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:484523
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    7. XM_006511028.4XP_006511091.1  transducin-like enhancer protein 3 isoform X7

      UniProtKB/TrEMBL
      E0CXS2
      Related
      ENSMUSP00000124977.2, ENSMUST00000162583.8
      Conserved Domains (4) summary
      cd00200
      Location:481766
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:251469
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:486525
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9133
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    8. XM_017313278.2XP_017168767.1  transducin-like enhancer protein 3 isoform X6

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:483768
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:250471
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:488527
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    9. XM_006511030.4XP_006511093.1  transducin-like enhancer protein 3 isoform X10

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:478763
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:250466
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:483522
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    10. XM_017313279.2XP_017168768.1  transducin-like enhancer protein 3 isoform X8

      UniProtKB/TrEMBL
      E0CXS2
      Related
      ENSMUSP00000123723.2, ENSMUST00000159630.8
      Conserved Domains (4) summary
      cd00200
      Location:480765
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:250468
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:485524
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9132
      TLE_N; Groucho/TLE N-terminal Q-rich domain
    11. XM_006511031.4XP_006511094.1  transducin-like enhancer protein 3 isoform X11

      UniProtKB/TrEMBL
      E0CXS2
      Conserved Domains (4) summary
      cd00200
      Location:475760
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      pfam05109
      Location:250463
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      sd00039
      Location:480519
      7WD40; WD40 repeat [structural motif]
      pfam03920
      Location:9132
      TLE_N; Groucho/TLE N-terminal Q-rich domain

    RNA

    1. XR_003947845.1 RNA Sequence