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    tph1.L tryptophan hydroxylase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 387560, updated on 11-Apr-2024

    Summary

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    Official Symbol
    tph1.L
    Official Full Name
    tryptophan hydroxylase 1 L homeolog
    Primary source
    Xenbase:XB-GENE-996927
    Locus tag
    XELAEV_18021665mg
    See related
    EnsemblRapid:ENSXLAG00005019012
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    tph; tph1; tph1.S
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    Genomic context

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    See tph1.L in Genome Data Viewer
    Location:
    chromosome: 4L
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (491782..500495, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (494597..503445, complement)

    Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene myogenic differentiation 1 L homeolog Neighboring gene secretion regulating guanine nucleotide exchange factor L homeolog Neighboring gene uncharacterized LOC108713700 Neighboring gene serum amyloid A like 1 L homeolog Neighboring gene general transcription factor IIH subunit 1 L homeolog

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tryptophan hydroxylase expression is regulated by a circadian clock in Xenopus laevis retina. Green CB, et al. J Neurochem, 1994 Jun. PMID 8189245

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tryptophan 5-monooxygenase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within aromatic amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within platelet degranulation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within regulation of hemostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within serotonin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within serotonin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tryptophan 5-hydroxylase
    Names
    tryptophan 5-monooxygenase
    tryptophan hydroxylase 1 S homeolog
    NP_001080923.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001087454.1 → NP_001080923.1  tryptophan 5-hydroxylase

      See identical proteins and their annotated locations for NP_001080923.1

      Status: PROVISIONAL

      Source sequence(s)
      L20679
      UniProtKB/Swiss-Prot
      Q92142
      UniProtKB/TrEMBL
      A0A974HMY2
      Related
      ENSXLAP00005056086.1, ENSXLAT00005057315.1
      Conserved Domains (3) summary
      TIGR01270
      Location:53 → 476
      Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
      cd04929
      Location:55 → 128
      ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
      pfam00351
      Location:143 → 473
      Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      491782..500495 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q92142.1 GenPept UniProtKB/Swiss-Prot:Q92142

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