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    rraB ribonuclease E inhibitor protein B [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948773, updated on 3-Nov-2024

    Summary

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    Official Symbol
    rraB
    Official Full Name
    ribonuclease E inhibitor protein B
    Primary source
    ECOCYC:G7885
    Locus tag
    b4255
    See related
    ASAP:ABE-0013936
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4248; yjgD
    Summary
    RraB binds to the C-terminal half (CTH) of RNase E and interferes with the cleavage of a subset of RNase E target transcripts in vitro and in vivo. [More information is available at EcoCyc: G7885].
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    Genomic context

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    Sequence:
    NC_000913.3 (4478473..4478889)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YjgL Neighboring gene ornithine carbamoyltransferase ArgI Neighboring gene putative N-acetyltransferase YjgM Neighboring gene inner membrane protein YjgN

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Preliminary crystallographic analysis of RraB from Escherichia coli. Shen H, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Nov. PMID 24192366, Free PMC Article
    2. Homologous control sites and DNA transcription starts in the related argF and argI genes of Escherichia coli K12. Piette J, et al. EMBO J, 1982. PMID 6329710, Free PMC Article
    3. Transcriptional regulation of the Escherichia coli gene rraB, encoding a protein inhibitor of RNase E. Zhou L, et al. J Bacteriol, 2009 Nov. PMID 19717586, Free PMC Article
    4. Functional implications of the conserved action of regulators of ribonuclease activity. Yeom JH, et al. J Microbiol Biotechnol, 2008 Aug. PMID 18756093
    5. Poly(A)-assisted RNA decay and modulators of RNA stability. Régnier P, et al. Prog Mol Biol Transl Sci, 2009. PMID 19215772

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RraA and RraB have a conserved property to directly act on RNAse E-related enzymes and inhibit their ribonucleolytic activity.
      Title: Inhibitory effects of RraA and RraB on RNAse E-related enzymes imply conserved functions in the regulated enzymatic cleavage of RNA.
    2. expression of RraA or RraB is accompanied by specific changes in degradosome composition--and that these are in turn associated with alterations in RNA decay
      Title: Differential modulation of E. coli mRNA abundance by inhibitory proteins that alter the composition of the degradosome.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables endoribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables endoribonuclease inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribonuclease inhibitor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within mRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endoribonuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of endoribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ribonuclease E inhibitor protein B

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4478473..4478889
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418676.1 ribonuclease E inhibitor protein B [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418676.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AQK1
      Conserved Domains (1) summary
      PRK11191
      Location:1 → 138
      PRK11191; ribonuclease E inhibitor RraB
    Nucleotide Protein
    Heading Accession and Version

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