ID3 inhibitor of DNA binding 3, HLH protein [Gallus gallus (chicken)] - Gene

Summary

Symbol: ID3provided by CGNC
Full Name: inhibitor of DNA binding 3, HLH proteinprovided by CGNC
Primary source: CGNC:49242
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 23

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	23	NC_052554.1 (2577964..2579597, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	23	NC_052595.1 (2346320..2347955, complement)

Chromosome 23 - NC_052554.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Increased bone morphogenetic protein signaling induces expression of Id1, Id2,and Id3 along the prosensory domains of the inner ear.
Title: Id gene regulation and function in the prosensory domains of the chicken inner ear: a link between Bmp signaling and Atoh1.
ID3 is not only a positive regulator of hepatoblast proliferation, but also an inhibitor of their differentiation into hepatocytes in the developing chick liver.
Title: Id3 is important for proliferation and differentiation of the hepatoblasts during the chick liver development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transcription regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in circadian regulation of gene expression	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: DNA-binding protein inhibitor ID-3

Names: helix-loop-helix protein; inhibitor of DNA binding 3, dominant negative helix-loop-helix protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204589.2 → NP_989920.1 DNA-binding protein inhibitor ID-3

Status: VALIDATED

Source sequence(s)

JAENSK010000339

UniProtKB/TrEMBL

Q90X14

Conserved Domains (1) summary

smart00353
Location:47 → 90

HLH; helix loop helix domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052554.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

2577964..2579597 complement

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GenBank, FASTA, Sequence Viewer (Graphics)