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    Kif24 kinesin family member 24 [ Mus musculus (house mouse) ]

    Gene ID: 109242, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Kif24provided by MGI
    Official Full Name
    kinesin family member 24provided by MGI
    Primary source
    MGI:MGI:1918345
    See related
    Ensembl:ENSMUSG00000028438 AllianceGenome:MGI:1918345
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4933425J19Rik; 9430029L23Rik
    Summary
    Predicted to enable identical protein binding activity and microtubule motor activity. Predicted to be involved in cilium assembly; microtubule depolymerization; and negative regulation of cilium assembly. Predicted to be located in centriole and centrosome. Predicted to be part of protein-containing complex. Predicted to be active in microtubule. Is expressed in cerebral cortex. Orthologous to human KIF24 (kinesin family member 24). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis adult (RPKM 3.9), CNS E11.5 (RPKM 2.1) and 19 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Kif24 in Genome Data Viewer
    Location:
    4 A5; 4 21.51 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (41389774..41464918, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (41389964..41464919, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:41295845-41296146 Neighboring gene predicted gene, 26084 Neighboring gene ubiquitin-associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_10033 Neighboring gene STARR-positive B cell enhancer ABC_E277 Neighboring gene nudix hydrolase 2 Neighboring gene STARR-seq mESC enhancer starr_10034 Neighboring gene myogenesis regulating glycosidase (putative)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cenpj Regulates Cilia Disassembly and Neurogenesis in the Developing Mouse Cortex. Ding W, et al. J Neurosci, 2019 Mar 13. PMID 30626697, Free PMC Article
    2. The CP110-interacting proteins Talpid3 and Cep290 play overlapping and distinct roles in cilia assembly. Kobayashi T, et al. J Cell Biol, 2014 Jan 20. PMID 24421332, Free PMC Article
    3. All kinesin superfamily protein, KIF, genes in mouse and human. Miki H, et al. Proc Natl Acad Sci U S A, 2001 Jun 19. PMID 11416179, Free PMC Article
    4. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    5. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microtubule motor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables microtubule motor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cilium assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    kinesin-like protein KIF24

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024241.3 → NP_077203.2  kinesin-like protein KIF24

      See identical proteins and their annotated locations for NP_077203.2

      Status: VALIDATED

      Source sequence(s)
      AL807823, BX470237
      Consensus CDS
      CCDS18060.2
      UniProtKB/Swiss-Prot
      A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
      Related
      ENSMUSP00000103690.3, ENSMUST00000108055.9
      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 539
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      41389774..41464918 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163576.1 → XP_036019469.1  kinesin-like protein KIF24 isoform X2

      Related
      ENSMUSP00000030148.6, ENSMUST00000030148.6
      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 467
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    2. XM_036163575.1 → XP_036019468.1  kinesin-like protein KIF24 isoform X2

      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 467
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    3. XM_006537549.5 → XP_006537612.1  kinesin-like protein KIF24 isoform X1

      See identical proteins and their annotated locations for XP_006537612.1

      UniProtKB/Swiss-Prot
      A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 539
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    4. XM_030253078.2 → XP_030108938.1  kinesin-like protein KIF24 isoform X1

      UniProtKB/Swiss-Prot
      A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 539
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    5. XM_030253077.2 → XP_030108937.1  kinesin-like protein KIF24 isoform X1

      UniProtKB/Swiss-Prot
      A2BGK6, Q6NWW5, Q8BUI2, Q99PT7
      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cd01367
      Location:218 → 539
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    6. XM_006537551.3 → XP_006537614.1  kinesin-like protein KIF24 isoform X4

      Conserved Domains (1) summary
      cd01367
      Location:1 → 222
      KISc_KIF2_like; Kinesin motor domain, KIF2-like group

    7. XM_030253079.1 → XP_030108939.1  kinesin-like protein KIF24 isoform X5

      Conserved Domains (1) summary
      cl22853
      Location:9 → 183
      Motor_domain; Myosin and Kinesin motor domain

    8. XM_017319913.2 → XP_017175402.1  kinesin-like protein KIF24 isoform X3

      Conserved Domains (2) summary
      cd09541
      Location:3 → 62
      SAM_KIF24-like; SAM domain of KIF24-like subfamily
      cl22853
      Location:201 → 373
      Motor_domain; Myosin and Kinesin motor domain

    9. XM_036163577.1 → XP_036019470.1  kinesin-like protein KIF24 isoform X5

      Conserved Domains (1) summary
      cl22853
      Location:9 → 183
      Motor_domain; Myosin and Kinesin motor domain

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145101.1: Suppressed sequence

      Description
      NM_145101.1: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6NWW5.2 GenPept UniProtKB/Swiss-Prot:Q6NWW5

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