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    TMEM176B transmembrane protein 176B [ Homo sapiens (human) ]

    Gene ID: 28959, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TMEM176Bprovided by HGNC
    Official Full Name
    transmembrane protein 176Bprovided by HGNC
    Primary source
    HGNC:HGNC:29596
    See related
    Ensembl:ENSG00000106565 MIM:610385; AllianceGenome:HGNC:29596
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    LR8; MS4B2
    Summary
    Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in liver (RPKM 288.9), kidney (RPKM 126.6) and 16 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TMEM176B in Genome Data Viewer
    Location:
    7q36.1
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (150791301..150801360, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (151964072..151974120, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150488389..150498448, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18783 Neighboring gene Bet1 golgi vesicular membrane trafficking protein pseudogene 1 Neighboring gene uncharacterized LOC105375566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150496449-150497148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497149-150497848 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:150497849-150498548 Neighboring gene transmembrane protein 176A Neighboring gene uncharacterized LOC105375567 Neighboring gene uncharacterized LOC124901775 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150549187-150549758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:150553923-150554766 Neighboring gene amine oxidase copper containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation. Cambui RAG, et al. J Cancer Res Clin Oncol, 2023 Jul. PMID 35980484
    2. The intracellular cation channel TMEM176B as a dual immunoregulator. Hill M, et al. Front Cell Dev Biol, 2022. PMID 36340035, Free PMC Article
    3. Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology. Cuajungco MP, et al. Acta Histochem, 2012 Nov. PMID 22244448, Free PMC Article
    4. Gene expression profile of renal proximal tubules regulated by proteinuria. Nakajima H, et al. Kidney Int, 2002 May. PMID 11967007
    5. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. Louvet C, et al. Am J Transplant, 2005 Sep. PMID 16095493

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.
      Title: The Ala134Thr variant in TMEM176B exerts a beneficial role in colorectal cancer prognosis by increasing NLRP3 inflammasome activation.
    2. TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.
      Title: TMEM176B Regulates AKT/mTOR Signaling and Tumor Growth in Triple-Negative Breast Cancer.
    3. TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.
      Title: TMEM176A and TMEM176B Are Candidate Regulators of Inhibition of Dendritic Cell Maturation and Function after Chronic Spinal Cord Injury.
    4. Study characterized Tmem176a and b expression in RORgamma t+ lymphocytes at transcriptional and protein levels and present evidence that both genes exert a redundant ion channel function related to a colocalisation in close proximity to the Golgi apparatus.
      Title: RORÎłt+ cells selectively express redundant cation channels linked to the Golgi apparatus.
    5. human TMEM176A and 176B protein levels are significantly elevated in lymphoma, but not in normal tissues
      Title: Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ26014, MGC110857

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in animal organ morphogenesis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of dendritic cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 176B
    Names
    LR8-like protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001101311.2 → NP_001094781.1  transmembrane protein 176B isoform a

      See identical proteins and their annotated locations for NP_001094781.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AK000841, AK129525, BC091471, BI761752, BI910761
      Consensus CDS
      CCDS5908.1
      UniProtKB/Swiss-Prot
      B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
      UniProtKB/TrEMBL
      A0A090N7V7, B3KUI8
      Conserved Domains (1) summary
      pfam04103
      Location:66 → 229
      CD20; CD20-like family

    2. NM_001101312.2 → NP_001094782.1  transmembrane protein 176B isoform a

      See identical proteins and their annotated locations for NP_001094782.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AK000841, AK129525, BC091471, BI761752
      Consensus CDS
      CCDS5908.1
      UniProtKB/Swiss-Prot
      B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
      UniProtKB/TrEMBL
      A0A090N7V7, B3KUI8
      Related
      ENSP00000318409.5, ENST00000326442.10
      Conserved Domains (1) summary
      pfam04103
      Location:66 → 229
      CD20; CD20-like family

    3. NM_001101314.2 → NP_001094784.1  transmembrane protein 176B isoform b

      See identical proteins and their annotated locations for NP_001094784.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform b) is shorter than isoform a.
      Source sequence(s)
      AK000841, AK129525, BC091471
      Consensus CDS
      CCDS47746.1
      UniProtKB/TrEMBL
      B3KUI8
      Related
      ENSP00000404831.2, ENST00000450753.2
      Conserved Domains (1) summary
      pfam04103
      Location:69 → 192
      CD20; CD20-like family

    4. NM_001362691.2 → NP_001349620.1  transmembrane protein 176B isoform c

      Status: VALIDATED

      Source sequence(s)
      AK000841, AK129525, BC091471, BI761752, BI910761, BP370662
      UniProtKB/TrEMBL
      B3KUI8
      Conserved Domains (1) summary
      pfam04103
      Location:82 → 245
      CD20; CD20-like family

    5. NM_001362692.2 → NP_001349621.1  transmembrane protein 176B isoform c

      Status: VALIDATED

      Source sequence(s)
      AK000841, AK129525, BC091471, BI761752, BP370662
      UniProtKB/TrEMBL
      B3KUI8
      Conserved Domains (1) summary
      pfam04103
      Location:82 → 245
      CD20; CD20-like family

    6. NM_014020.4 → NP_054739.3  transmembrane protein 176B isoform a

      See identical proteins and their annotated locations for NP_054739.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform a. Variants 1-4 encode the same isoform.
      Source sequence(s)
      AK000841, BC004358, BI759037, BP298052
      Consensus CDS
      CCDS5908.1
      UniProtKB/Swiss-Prot
      B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
      UniProtKB/TrEMBL
      A0A090N7V7, B3KUI8
      Related
      ENSP00000410269.2, ENST00000447204.6
      Conserved Domains (1) summary
      pfam04103
      Location:66 → 229
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      150791301..150801360 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006715933.5 → XP_006715996.2  transmembrane protein 176B isoform X1

      See identical proteins and their annotated locations for XP_006715996.2

      UniProtKB/TrEMBL
      B3KUI8
      Conserved Domains (1) summary
      pfam04103
      Location:69 → 192
      CD20; CD20-like family

    2. XM_047420259.1 → XP_047276215.1  transmembrane protein 176B isoform X2

      UniProtKB/Swiss-Prot
      B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
      UniProtKB/TrEMBL
      A0A090N7V7

    3. XM_047420258.1 → XP_047276214.1  transmembrane protein 176B isoform X3

    4. XM_024446734.2 → XP_024302502.1  transmembrane protein 176B isoform X2

      UniProtKB/Swiss-Prot
      B2RDK2, D3DWZ7, E9PAV4, Q3YBM2, Q5BJI2, Q9BT42, Q9Y609
      UniProtKB/TrEMBL
      A0A090N7V7, B3KUI8
      Related
      ENSP00000397810.2, ENST00000429904.6
      Conserved Domains (1) summary
      pfam04103
      Location:66 → 229
      CD20; CD20-like family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      151964072..151974120 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357983.1 → XP_054213958.1  transmembrane protein 176B isoform X1

    2. XM_054357985.1 → XP_054213960.1  transmembrane protein 176B isoform X2

    3. XM_054357984.1 → XP_054213959.1  transmembrane protein 176B isoform X2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001101313.1: Suppressed sequence

      Description
      NM_001101313.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3YBM2.2 GenPept UniProtKB/Swiss-Prot:Q3YBM2

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