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    Ankmy2 ankyrin repeat and MYND domain containing 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314046, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Ankmy2provided by RGD
    Official Full Name
    ankyrin repeat and MYND domain containing 2provided by RGD
    Primary source
    RGD:1306017
    See related
    EnsemblRapid:ENSRNOG00000005623 AllianceGenome:RGD:1306017
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable enzyme binding activity. Predicted to be located in cilium. Orthologous to human ANKMY2 (ankyrin repeat and MYND domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Heart (RPKM 161.5), Spleen (RPKM 120.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ankmy2 in Genome Data Viewer
    Location:
    6q16
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (58616251..58657634)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (52888959..52930343)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (55646905..55689223)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479367 Neighboring gene basic leucine zipper and W2 domains 2 Neighboring gene non-POU domain containing, octamer-binding, pseudogene 3 Neighboring gene leucine rich repeat containing 72 Neighboring gene MYC associated factor X, pseudogene 2 Neighboring gene ribosomal protein S26, pseudogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Localization of a guanylyl cyclase to chemosensory cilia requires the novel ciliary MYND domain protein DAF-25. Jensen VL, et al. PLoS Genet, 2010 Nov 24. PMID 21124868, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cilium IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ankyrin repeat and MYND domain-containing protein 2
    Names
    guanine nucleotide binding protein, alpha 14

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108019.1 → NP_001101489.1  ankyrin repeat and MYND domain-containing protein 2 isoform 2

      See identical proteins and their annotated locations for NP_001101489.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473947
      UniProtKB/TrEMBL
      A6HBB0, D3ZC34
      Related
      ENSRNOP00000062801.1, ENSRNOT00000064822.4
      Conserved Domains (4) summary
      cd00204
      Location:31 → 132
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam01753
      Location:295 → 314
      zf-MYND; MYND finger
      pfam13857
      Location:31 → 87
      Ank_5; Ankyrin repeats (many copies)
      sd00045
      Location:16 → 43
      ANK; ANK repeat [structural motif]

    2. NM_001399649.1 → NP_001386578.1  ankyrin repeat and MYND domain-containing protein 2 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A0G2K8N6
      Related
      ENSRNOP00000074676.1, ENSRNOT00000091488.3

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      58616251..58657634
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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