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    PSPH phosphoserine phosphatase [ Homo sapiens (human) ]

    Gene ID: 5723, updated on 2-Nov-2024

    Summary

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    Official Symbol
    PSPHprovided by HGNC
    Official Full Name
    phosphoserine phosphataseprovided by HGNC
    Primary source
    HGNC:HGNC:9577
    See related
    Ensembl:ENSG00000146733 MIM:172480; AllianceGenome:HGNC:9577
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PSP; PSPHD
    Summary
    The protein encoded by this gene belongs to a subfamily of the phosphotransferases. This encoded enzyme is responsible for the third and last step in L-serine formation. It catalyzes magnesium-dependent hydrolysis of L-phosphoserine and is also involved in an exchange reaction between L-serine and L-phosphoserine. Deficiency of this protein is thought to be linked to Williams syndrome. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in kidney (RPKM 3.8), thyroid (RPKM 3.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PSPH in Genome Data Viewer
    Location:
    7p11.2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (56011064..56051444, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (56170861..56211278, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (56078757..56119137, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26043 Neighboring gene mitochondrial ribosomal protein S17 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18192 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:56032587-56033320 Neighboring gene nipsnap homolog 2 Neighboring gene MPRA-validated peak6528 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26045 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26047 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26048 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18194 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26049 Neighboring gene small nucleolar RNA, H/ACA box 22B Neighboring gene chaperonin containing TCP1 subunit 6A Neighboring gene small nucleolar RNA, H/ACA box 15

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Gene dosage effect in acquired monosomy 7: distinct behaviour of beta-glucuronidase and phosphoserine phosphatase. Minelli A, et al. Genes Chromosomes Cancer, 1990 Jan. PMID 1964582
    2. Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan. Vincent JB, et al. Clin Genet, 2015 Mar. PMID 25080166
    3. Molecular basis for the local conformational rearrangement of human phosphoserine phosphatase. Kim HY, et al. J Biol Chem, 2002 Nov 29. PMID 12213811
    4. Purification, crystallization and preliminary X-ray diffraction analysis of human phosphoserine phosphatase. Peeraer Y, et al. Acta Crystallogr D Biol Crystallogr, 2002 Jan. PMID 11752790
    5. Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. Sato K, et al. Anticancer Res, 2017 May. PMID 28476802

    See all (48) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
      Title: PSPH promotes melanoma growth and metastasis by metabolic deregulation-mediated transcriptional activation of NR4A1.
    2. a specific interaction between PSPH and IRS1 and the dephosphorylation of phospho-IRS-1 by PSPH in lung cancer cells, was identified.
      Title: Phosphoserine Phosphatase Promotes Lung Cancer Progression through the Dephosphorylation of IRS-1 and a Noncanonical L-Serine-Independent Pathway.
    3. The results suggest that PSPH may act as a putative oncogene and a potential therapeutic target in NSCLC.
      Title: PSPH Mediates the Metastasis and Proliferation of Non-small Cell Lung Cancer through MAPK Signaling Pathways.
    4. three new high-resolution crystal structures of hPSP (1.5-2.0 A) in complexes with phosphoserine and with serine, which are the substrate and the product of the reaction, respectively, and in complex with a noncleavable substrate analogue (homocysteic acid) are presented.
      Title: Crystal structures and snapshots along the reaction pathway of human phosphoserine phosphatase.
    5. PSPH expression is a novel biomarker for poor prognosis and could play an important role in tumor progression of colorectal cancer.
      Title: Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer.
    6. We further uncovered that phosphoserine phosphatase (PSPH), the final rate-limiting enzyme of the SSP pathway, is critical for cMyc-driven cancer progression both in vitro and in vivo
      Title: cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions.
    7. study of an intellectual disability family from Pakistan; identified a variant in PSPH: chr7:56088803C>T, NM_004577.3 c.103G>A; p.Ala35Thr (hg19) which segregated in homozygous form with the phenotype in both branches of the family
      Title: Phosphoserine phosphatase (PSPH) gene mutation in an intellectual disability family from Pakistan.
    8. phosphoserine phosphatase deficiency is associated with Neu-Laxova syndrome.
      Title: Neu-Laxova syndrome is a heterogeneous metabolic disorder caused by defects in enzymes of the L-serine biosynthesis pathway.
    9. status of PSPH in normal skin epidermis and skin tumors along with its sub-cellular localization in epidermal keratinocytes and its requirement for squamous cell carcinoma proliferation
      Title: L-3-Phosphoserine phosphatase (PSPH) regulates cutaneous squamous cell carcinoma proliferation independent of L-serine biosynthesis.
    10. human phosphoserine phosphatase structure now shows a sevenfold coordinated Ca(2+) ion in the active site that might explain the inhibitory effect of Ca(2+) on the enzyme
      Title: How calcium inhibits the magnesium-dependent enzyme human phosphoserine phosphatase.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Deficiency of phosphoserine phosphatase
    MedGen: C1291463 OMIM: 614023 GeneReviews: Serine Deficiency Disorders
    		Compare labs

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog
    Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-phosphoserine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables L-phosphoserine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables L-phosphoserine phosphatase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables magnesium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-serine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-serine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in L-serine metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in in utero embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to nutrient levels IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to testosterone IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    phosphoserine phosphatase
    Names
    L-3-phosphoserine phosphatase
    O-phosphoserine phosphohydrolase
    PSPase
    NP_001357432.1
    NP_001357433.1
    NP_001357434.1
    NP_001357435.1
    NP_001357436.1
    NP_001357437.1
    NP_001357438.1
    NP_001357439.1
    NP_001357440.1
    NP_001357441.1
    NP_001357442.1
    NP_001357443.1
    NP_001357444.1
    NP_001357445.1
    NP_001357446.1
    NP_001357447.1
    NP_001357448.1
    NP_001357449.1
    NP_001357450.1
    NP_001357451.1
    NP_004568.2
    XP_006715824.1
    XP_016867956.1
    XP_016867957.1
    XP_016867958.1
    XP_047276600.1
    XP_047276601.1
    XP_047276602.1
    XP_047276603.1
    XP_047276604.1
    XP_047276605.1
    XP_047276606.1
    XP_047276607.1
    XP_047276608.1
    XP_047276609.1
    XP_047276610.1
    XP_054214668.1
    XP_054214669.1
    XP_054214670.1
    XP_054214671.1
    XP_054214672.1
    XP_054214673.1
    XP_054214674.1
    XP_054214675.1
    XP_054214676.1
    XP_054214677.1
    XP_054214678.1
    XP_054214679.1
    XP_054214680.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011473.1 RefSeqGene

      Range
      5132..45512
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001370503.1 → NP_001357432.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Related
      ENSP00000378854.3, ENST00000395471.7
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    2. NM_001370504.1 → NP_001357433.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    3. NM_001370505.1 → NP_001357434.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    4. NM_001370506.1 → NP_001357435.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    5. NM_001370507.1 → NP_001357436.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    6. NM_001370508.1 → NP_001357437.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    7. NM_001370509.1 → NP_001357438.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Related
      ENSP00000401639.2, ENST00000437355.6
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    8. NM_001370510.1 → NP_001357439.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    9. NM_001370511.1 → NP_001357440.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    10. NM_001370512.1 → NP_001357441.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Related
      ENSP00000398653.1, ENST00000421626.5
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    11. NM_001370513.1 → NP_001357442.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    12. NM_001370514.1 → NP_001357443.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    13. NM_001370515.1 → NP_001357444.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    14. NM_001370516.1 → NP_001357445.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    15. NM_001370517.1 → NP_001357446.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    16. NM_001370518.1 → NP_001357447.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    17. NM_001370519.1 → NP_001357448.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    18. NM_001370520.1 → NP_001357449.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    19. NM_001370521.1 → NP_001357450.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    20. NM_001370522.1 → NP_001357451.1  phosphoserine phosphatase

      Status: REVIEWED

      Source sequence(s)
      AC092579
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    21. NM_004577.4 → NP_004568.2  phosphoserine phosphatase

      See identical proteins and their annotated locations for NP_004568.2

      Status: REVIEWED

      Source sequence(s)
      AW574794, BC052958, BC063614, Y10275
      Consensus CDS
      CCDS5522.1
      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Related
      ENSP00000275605.3, ENST00000275605.8
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      56011064..56051444 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047420650.1 → XP_047276606.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    2. XM_047420652.1 → XP_047276608.1  phosphoserine phosphatase isoform X2

    3. XM_017012469.3 → XP_016867958.1  phosphoserine phosphatase isoform X2

      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (2) summary
      pfam00702
      Location:47 → 141
      Hydrolase; haloacid dehalogenase-like hydrolase
      cl21460
      Location:10 → 179
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    4. XM_047420649.1 → XP_047276605.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    5. XM_006715761.3 → XP_006715824.1  phosphoserine phosphatase isoform X2

      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (2) summary
      pfam00702
      Location:47 → 141
      Hydrolase; haloacid dehalogenase-like hydrolase
      cl21460
      Location:10 → 179
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    6. XM_017012468.3 → XP_016867957.1  phosphoserine phosphatase isoform X2

      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (2) summary
      pfam00702
      Location:47 → 141
      Hydrolase; haloacid dehalogenase-like hydrolase
      cl21460
      Location:10 → 179
      HAD_like; Haloacid Dehalogenase-like Hydrolases

    7. XM_047420644.1 → XP_047276600.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    8. XM_047420645.1 → XP_047276601.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    9. XM_047420647.1 → XP_047276603.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    10. XM_047420648.1 → XP_047276604.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    11. XM_047420646.1 → XP_047276602.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    12. XM_047420653.1 → XP_047276609.1  phosphoserine phosphatase isoform X2

    13. XM_017012467.3 → XP_016867956.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5
      UniProtKB/TrEMBL
      Q53EY1
      Conserved Domains (1) summary
      cd04309
      Location:15 → 216
      HAD_PSP_eu; phosphoserine phosphatase eukaryotic-like, similar to human phosphoserine phosphatase

    14. XM_047420651.1 → XP_047276607.1  phosphoserine phosphatase isoform X2

    15. XM_047420654.1 → XP_047276610.1  phosphoserine phosphatase isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      56170861..56211278 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358699.1 → XP_054214674.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    2. XM_054358703.1 → XP_054214678.1  phosphoserine phosphatase isoform X2

    3. XM_054358704.1 → XP_054214679.1  phosphoserine phosphatase isoform X2

    4. XM_054358698.1 → XP_054214673.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    5. XM_054358700.1 → XP_054214675.1  phosphoserine phosphatase isoform X2

    6. XM_054358701.1 → XP_054214676.1  phosphoserine phosphatase isoform X2

    7. XM_054358693.1 → XP_054214668.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    8. XM_054358695.1 → XP_054214670.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    9. XM_054358696.1 → XP_054214671.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    10. XM_054358694.1 → XP_054214669.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    11. XM_054358697.1 → XP_054214672.1  phosphoserine phosphatase isoform X1

      UniProtKB/Swiss-Prot
      B2RCR5, P78330, Q7Z3S5

    12. XM_054358702.1 → XP_054214677.1  phosphoserine phosphatase isoform X2

    13. XM_054358705.1 → XP_054214680.1  phosphoserine phosphatase isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78330.2 GenPept UniProtKB/Swiss-Prot:P78330

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