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    RGS4 regulator of G protein signaling 4 [ Homo sapiens (human) ]

    Gene ID: 5999, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RGS4provided by HGNC
    Official Full Name
    regulator of G protein signaling 4provided by HGNC
    Primary source
    HGNC:HGNC:10000
    See related
    Ensembl:ENSG00000117152 MIM:602516; AllianceGenome:HGNC:10000
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RGP4; SCZD9
    Summary
    Regulator of G protein signaling (RGS) family members are regulatory molecules that act as GTPase activating proteins (GAPs) for G alpha subunits of heterotrimeric G proteins. RGS proteins are able to deactivate G protein subunits of the Gi alpha, Go alpha and Gq alpha subtypes. They drive G proteins into their inactive GDP-bound forms. Regulator of G protein signaling 4 belongs to this family. All RGS proteins share a conserved 120-amino acid sequence termed the RGS domain. Regulator of G protein signaling 4 protein is 37% identical to RGS1 and 97% identical to rat Rgs4. This protein negatively regulate signaling upstream or at the level of the heterotrimeric G protein and is localized in the cytoplasm. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 67.5), adrenal (RPKM 15.7) and 1 other tissue See more
    Orthologs
    mouse all
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    Genomic context

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    See RGS4 in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (163068871..163076802)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (162413422..162421357)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (163038661..163046592)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit 7B, mitochondrial-like Neighboring gene NANOG hESC enhancer GRCh37_chr1:162971378-162971879 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:163005147-163006346 Neighboring gene uncharacterized LOC107985223 Neighboring gene uncharacterized LOC124904446 Neighboring gene RGS4-RGS5 intergenic ENCODE-defined enhancer Neighboring gene NANOG hESC enhancer GRCh37_chr1:163101622-163102196 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_592 Neighboring gene regulator of G protein signaling 5 Neighboring gene RGS5 antisense RNA 1 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:163172770-163173435 Neighboring gene TRNT1 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. An association study of RGS4 polymorphisms with clinical phenotypes of schizophrenia in a Chinese population. So HC, et al. Am J Med Genet B Neuropsychiatr Genet, 2008 Jan 5. PMID 17722013
    2. Evaluation of RGS4 as a candidate gene for schizophrenia. Liu YL, et al. Am J Med Genet B Neuropsychiatr Genet, 2006 Jun 5. PMID 16526029
    3. RGS4 genotype is not associated with antipsychotic medication response in schizophrenia. Kampman O, et al. J Neural Transm (Vienna), 2006 Oct. PMID 16604300
    4. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Talkowski ME, et al. Biol Psychiatry, 2006 Jul 15. PMID 16631129, Free PMC Article
    5. Making the case for a candidate vulnerability gene in schizophrenia: Convergent evidence for regulator of G-protein signaling 4 (RGS4). Levitt P, et al. Biol Psychiatry, 2006 Sep 15. PMID 16860780

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.
      Title: RGS4 controls airway hyperresponsiveness through GAP-independent mechanisms.
    2. Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
      Title: Cardiac RGS Proteins in Human Heart Failure and Atrial Fibrillation: Focus on RGS4.
    3. Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
      Title: Regulator of G-Protein Signalling 4 (RGS4) negatively modulates nociceptin/orphanin FQ opioid receptor signalling: Implication for l-Dopa-induced dyskinesia.
    4. Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
      Title: Regulator of G-Protein Signaling-4 Attenuates Cardiac Adverse Remodeling and Neuronal Norepinephrine Release-Promoting Free Fatty Acid Receptor FFAR3 Signaling.
    5. RGS4 controls Galphai3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
      Title: RGS4 controls Gαi3-mediated regulation of Bcl-2 phosphorylation on TGN38-containing intracellular membranes.
    6. miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
      Title: miR-874-3p inhibits cell migration through targeting RGS4 in osteosarcoma.
    7. Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Galpha in live cells.
      Title: Regulators of G-protein signaling, RGS2 and RGS4, inhibit protease-activated receptor 4-mediated signaling by forming a complex with the receptor and Gα in live cells.
    8. RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
      Title: RGS4 promotes allergen- and aspirin-associated airway hyperresponsiveness by inhibiting PGE2 biosynthesis.
    9. Targeting RGS4 Ablates Glioblastoma Proliferation.
      Title: Targeting RGS4 Ablates Glioblastoma Proliferation.
    10. lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
      Title: lncRNA RPL34-AS1 inhibits cell proliferation and invasion while promoting apoptosis by competitively binding miR-3663-3p/RGS4 in papillary thyroid cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (85)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of regulator of G-protein signaling 4 (RGS4) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC2124, MGC60244, DKFZp761F1924

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G-protein alpha-subunit binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    		  
    enables calmodulin binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in dorsal root ganglion development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth involved in cardiac muscle cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of dopamine receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of glycine import across plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of heart rate IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of G protein-coupled receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of actin filament organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of calcium ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to amphetamine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to cocaine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    regulator of G-protein signaling 4
    Names
    schizophrenia disorder 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023312.1 RefSeqGene

      Range
      5756..13197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001102445.3 → NP_001095915.1  regulator of G-protein signaling 4 isoform 1

      See identical proteins and their annotated locations for NP_001095915.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AL583850, DQ346664
      Consensus CDS
      CCDS44270.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000397181.2, ENST00000421743.6
      Conserved Domains (1) summary
      cd08714
      Location:160 → 273
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    2. NM_001113380.1 → NP_001106851.1  regulator of G-protein signaling 4 isoform 3

      See identical proteins and their annotated locations for NP_001106851.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two 5' exons but has an alternate 5' UTR exon, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (3) has a shorter N-terminus, as compared to isoform 1.
      Source sequence(s)
      AL583850, EF054877
      Consensus CDS
      CCDS44272.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356882.3, ENST00000367906.7
      Conserved Domains (1) summary
      cd08714
      Location:45 → 158
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    3. NM_001113381.1 → NP_001106852.1  regulator of G-protein signaling 4 isoform 4

      See identical proteins and their annotated locations for NP_001106852.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 5' sequence, which results in a downstream AUG start codon, and lacks an internal coding exon in the 3' region, as compared to variant 1. The resulting isoform (4) has a shorter N-terminus, and a shorter and distinct C-terminus, as compared to isoform 1.
      Source sequence(s)
      AK093959, AL583850, DA660695
      Consensus CDS
      CCDS44271.1
      UniProtKB/Swiss-Prot
      P49798
      Related
      ENSP00000356884.4, ENST00000367908.8

    4. NM_005613.6 → NP_005604.1  regulator of G-protein signaling 4 isoform 2

      See identical proteins and their annotated locations for NP_005604.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) has an alternate 5' sequence, which results in a downstream AUG start codon, as compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AL583850, DQ346663
      Consensus CDS
      CCDS1243.1
      UniProtKB/Swiss-Prot
      A7XA56, A7XA58, A7XA59, A7YVV7, B1APZ3, P49798
      Related
      ENSP00000356885.6, ENST00000367909.11
      Conserved Domains (1) summary
      cd08714
      Location:63 → 176
      RGS_RGS4; Regulator of G protein signaling (RGS) domain found in the RGS4 protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      163068871..163076802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      162413422..162421357
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P49798.1 GenPept UniProtKB/Swiss-Prot:P49798

    Gene LinkOut

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