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    FCRLA Fc receptor like A [ Homo sapiens (human) ]

    Gene ID: 84824, updated on 2-Nov-2024

    Summary

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    Official Symbol
    FCRLAprovided by HGNC
    Official Full Name
    Fc receptor like Aprovided by HGNC
    Primary source
    HGNC:HGNC:18504
    See related
    Ensembl:ENSG00000132185 MIM:606891; AllianceGenome:HGNC:18504
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FCRL; FCRX; FREB; FCRL1; FCRLX; FCRLb; FCRLd; FCRLe; FCRLM1; FCRLc1; FCRLc2
    Summary
    This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in lymph node (RPKM 32.1), spleen (RPKM 21.2) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FCRLA in Genome Data Viewer
    Location:
    1q23.3
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (161707229..161714352)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (161051554..161058676)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (161677019..161684142)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1483 Neighboring gene Fc gamma receptor IIb Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:161640790-161641368 Neighboring gene ribosomal protein L31 pseudogene 11 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1995 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1484 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1996 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1998 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1485 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1486 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1487 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1999 Neighboring gene Fc receptor like B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2000 Neighboring gene RNA, 7SL, cytoplasmic 466, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Soluble FcgammaRIIIa as a marker for rheumatoid arthritis: the use of genetics in selected populations to study pathogenetic pathways. Huizinga TW, et al. J Rheumatol, 2003 Sep. PMID 12966588
    2. Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma. Liu Y, et al. Biomed Res Int, 2020. PMID 32908921, Free PMC Article
    3. Fc receptor-like A promotes malignant behavior in renal cell carcinoma and correlates with tumor immune infiltration. Liu JP, et al. Cancer Med, 2024 Aug. PMID 39108036, Free PMC Article
    4. B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans. Reshetnikova E, et al. Cytometry B Clin Cytom, 2018 Jul. PMID 29236355
    5. FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells. Blackburn TE, et al. Curr Top Microbiol Immunol, 2017. PMID 28879521

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fc receptor-like A promotes malignant behavior in renal cell carcinoma and correlates with tumor immune infiltration.
      Title: Fc receptor-like A promotes malignant behavior in renal cell carcinoma and correlates with tumor immune infiltration.
    2. Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma.
      Title: Development and Validation of the B Cell-Associated Fc Receptor-like Molecule-Based Prognostic Signature in Skin Cutaneous Melanoma.
    3. FCRLA has long been viewed as a B cell specific protein, and this is the first time its expression has also been shown in human plasmacytoid dendritic cells
      Title: B cell-specific protein FCRLA is expressed by plasmacytoid dendritic cells in humans.
    4. FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells
      Title: FCRLA-A Resident Endoplasmic Reticulum Protein that Associates with Multiple Immunoglobulin Isotypes in B Lineage Cells.
    5. This first genome-wide association approach for cyclophosphamide response in lupus nephritis patients yielded a robust profile of genetic associations including large-effect SNP in the FCGR2B-FCRLA locus, which may provide better insights to cyclophosphamide metabolism and efficacy.
      Title: Response to Intravenous Cyclophosphamide Treatment for Lupus Nephritis Associated with Polymorphisms in the FCGR2B-FCRLA Locus.
    6. FCGR2C SNPs that associated with vaccine efficacy in RV144 also strongly associated with the expression of FCGR2A/C and one of them also associated with the expression of Fc receptor-like A (FCRLA), another Fc-gamma receptor (FcgammaR) gene
      Title: FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells.
    7. alternative splicing of FCRLA mRNA results in the production of isoforms differing by their domain composition and possessing either the short or long signal peptide.
      Title: Characterization of human FCRLA isoforms.
    8. The studies reported here demonstrate that FCRLA is more broadly expressed among human B lineage cells than originally reported; it is found at significant levels in resting blood B cells and at varying levels in all B-cell subsets in tonsil.
      Title: FCRLA is a resident endoplasmic reticulum protein that associates with intracellular Igs, IgM, IgG and IgA.
    9. Analysis of human cell lines has confirmed that FcRLA is not secreted but is maintained as an intracellular protein in B cells where it interacts with immunoglobulins.
      Title: Fc receptor-like A associates with intracellular IgG and IgM but is dispensable for antigen-specific immune responses.
    10. Observational study of gene-disease association. (HuGE Navigator)
      Title: New genetic associations detected in a host response study to hepatitis B vaccine.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC4595

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables transmembrane signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell surface receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Fc receptor-like A
    Names
    Fc receptor homolog expressed in B cells (FREB)
    Fc receptor related protein X
    Fc receptor-like and mucin-like 1
    fc receptor homolog expressed in B-cells
    fc receptor-like and mucin-like protein 1
    fc receptor-like protein
    fc receptor-related protein X

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001184866.2 → NP_001171795.2  Fc receptor-like A isoform 1 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1). This variant has also been called FCRLa1.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53415.2
      Related
      ENSP00000356930.3, ENST00000367953.7
      Conserved Domains (2) summary
      pfam13895
      Location:177 → 266
      Ig_2; Immunoglobulin domain
      cl11960
      Location:85 → 152
      Ig; Immunoglobulin domain

    2. NM_001184867.2 → NP_001171796.2  Fc receptor-like A isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1. This variant has also been called FCRLb.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53417.2
      Related
      ENSP00000439838.1, ENST00000546024.5
      Conserved Domains (1) summary
      pfam13895
      Location:82 → 171
      Ig_2; Immunoglobulin domain

    3. NM_001184870.2 → NP_001171799.2  Fc receptor-like A isoform 4 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 4) is shorter when it is compared to isoform 1. This variant has also been called FCRLc1.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53416.2
      Related
      ENSP00000442870.1, ENST00000540521.5
      Conserved Domains (1) summary
      pfam13895
      Location:37 → 126
      Ig_2; Immunoglobulin domain

    4. NM_001184871.2 → NP_001171800.2  Fc receptor-like A isoform 7

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks four alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 7) is shorter when it is compared to isoform 1. This variant has also been called FCRLe.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53420.1
      Related
      ENSP00000344808.3, ENST00000350710.3

    5. NM_001184872.2 → NP_001171801.2  Fc receptor-like A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 5) is shorter when it is compared to isoform 1. This variant has also been called FCRLc2.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53419.2
      Related
      ENSP00000356934.3, ENST00000367957.7
      Conserved Domains (1) summary
      pfam13895
      Location:31 → 120
      Ig_2; Immunoglobulin domain

    6. NM_001184873.2 → NP_001171802.2  Fc receptor-like A isoform 6 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three alternate, in-frame segments, compared to variant 1. The resulting protein (isoform 6) is shorter when it is compared to isoform 1. This variant has also been called FCRLd.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS53418.1
      UniProtKB/TrEMBL
      Q5VXA5
      Related
      ENSP00000356926.2, ENST00000367949.6

    7. NM_001366195.2 → NP_001353124.2  Fc receptor-like A isoform 8 precursor

      Status: REVIEWED

      Source sequence(s)
      AL359541
      Conserved Domains (2) summary
      pfam13895
      Location:176 → 265
      Ig_2; Immunoglobulin domain
      cl11960
      Location:84 → 151
      Ig; Immunoglobulin domain

    8. NM_001366196.2 → NP_001353125.2  Fc receptor-like A isoform 9 precursor

      Status: REVIEWED

      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS91091.1
      Related
      ENSP00000294798.7, ENST00000349527.8
      Conserved Domains (1) summary
      cl11960
      Location:79 → 146
      Ig; Immunoglobulin domain

    9. NM_032738.4 → NP_116127.4  Fc receptor-like A isoform 2 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate, in-frame segment, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1. This variant has also been called FCRLa.
      Source sequence(s)
      AL359541
      Consensus CDS
      CCDS30926.2
      UniProtKB/Swiss-Prot
      A0N0M1, A6NC03, A6NL20, F5H720, F8W743, G3V1J2, Q5VXA1, Q5VXA2, Q5VXA3, Q5VXA4, Q5VXB0, Q5VXB1, Q7L513, Q8NEW4, Q8WXH3, Q96PC6, Q96PJ0, Q96PJ1, Q96PJ2, Q96PJ4, Q9BR57
      Related
      ENSP00000236938.7, ENST00000236938.12
      Conserved Domains (2) summary
      pfam13895
      Location:171 → 260
      Ig_2; Immunoglobulin domain
      cl11960
      Location:79 → 146
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      161707229..161714352
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510065.2 → XP_011508367.2  Fc receptor-like A isoform X2

    2. XM_006711581.4 → XP_006711644.2  Fc receptor-like A isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      161051554..161058676
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054339259.1 → XP_054195234.1  Fc receptor-like A isoform X2

    2. XM_054339258.1 → XP_054195233.1  Fc receptor-like A isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7L513.2 GenPept UniProtKB/Swiss-Prot:Q7L513

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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