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    Mrpl27 mitochondrial ribosomal protein L27 [ Mus musculus (house mouse) ]

    Gene ID: 94064, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mrpl27provided by MGI
    Official Full Name
    mitochondrial ribosomal protein L27provided by MGI
    Primary source
    MGI:MGI:2137224
    See related
    Ensembl:ENSMUSG00000024414 AllianceGenome:MGI:2137224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D11Moh47; D18Ertd643e; A630055F16Rik
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to act upstream of or within translation. Located in mitochondrion. Is expressed in several structures, including brain; early conceptus; genitourinary system; heart; and liver. Orthologous to human MRPL27 (mitochondrial ribosomal protein L27). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 13.1), kidney adult (RPKM 10.5) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Mrpl27 in Genome Data Viewer
    Location:
    11 D; 11 58.9 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (94544593..94552758)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (94653770..94661932)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene acyl-CoA synthetase family member 2 Neighboring gene STARR-seq mESC enhancer starr_30470 Neighboring gene chondroadherin Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:94452878-94453079 Neighboring gene STARR-seq mESC enhancer starr_30472 Neighboring gene STARR-positive B cell enhancer mm9_chr11:94490883-94491183 Neighboring gene leucine rich repeat containing 59 Neighboring gene essential meiotic structure-specific endonuclease 1 Neighboring gene xylosyltransferase II Neighboring gene STARR-positive B cell enhancer ABC_E8444 Neighboring gene predicted gene 11541

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Comparative mapping of distal murine chromosome 11 and human 17q21.3 in a region containing a modifying locus for murine plasma von Willebrand factor level. Mohlke KL, et al. Genomics, 1998 Nov 15. PMID 9806826
    2. Structural compensation for the deficit of rRNA with proteins in the mammalian mitochondrial ribosome. Systematic analysis of protein components of the large ribosomal subunit from mammalian mitochondria. Suzuki T, et al. J Biol Chem, 2001 Jun 15. PMID 11279069
    3. Expression analysis of mammalian mitochondrial ribosomal protein genes. Cheong A, et al. Gene Expr Patterns, 2020 Dec. PMID 32987154, Free PMC Article
    4. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    5. Structure and Function of the Mitochondrial Ribosome. Greber BJ, et al. Annu Rev Biochem, 2016 Jun 2. PMID 27023846

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of ribosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in mitochondrial translation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within translation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of mitochondrial large ribosomal subunit NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein bL27m
    Names
    39S ribosomal protein L27, mitochondrial
    L27mt
    MRP-L27

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053161.2 → NP_444391.1  large ribosomal subunit protein bL27m

      See identical proteins and their annotated locations for NP_444391.1

      Status: PROVISIONAL

      Source sequence(s)
      BC030074
      Consensus CDS
      CCDS25263.1
      UniProtKB/Swiss-Prot
      Q99N92
      Related
      ENSMUSP00000025278.8, ENSMUST00000025278.8
      Conserved Domains (1) summary
      pfam01016
      Location:31 → 101
      Ribosomal_L27; Ribosomal L27 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      94544593..94552758
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534567.3 → XP_006534630.1  large ribosomal subunit protein bL27m isoform X1

      See identical proteins and their annotated locations for XP_006534630.1

      Conserved Domains (1) summary
      cl00359
      Location:11 → 57
      Ribosomal_L27; Ribosomal L27 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99N92.1 GenPept UniProtKB/Swiss-Prot:Q99N92

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