U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Rims2 regulating synaptic membrane exocytosis 2 [ Mus musculus (house mouse) ]

    Gene ID: 116838, updated on 2-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Rims2provided by MGI
    Official Full Name
    regulating synaptic membrane exocytosis 2provided by MGI
    Primary source
    MGI:MGI:2152972
    See related
    Ensembl:ENSMUSG00000037386 AllianceGenome:MGI:2152972
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RIM2; Serg2; Rab3ip2; Syt3-rs; Rim2(+4A); mKIAA0751; Rim2(+40A); Rim2(+44A); 2810036I15Rik
    Summary
    Enables protein-macromolecule adaptor activity and transmembrane transporter binding activity. A structural constituent of presynaptic active zone. Involved in several processes, including neurotransmitter secretion; regulation of calcium-dependent activation of synaptic vesicle fusion; and regulation of nervous system process. Acts upstream of or within several processes, including adenylate cyclase-modulating G protein-coupled receptor signaling pathway; regulation of exocytosis; and signal release. Located in inhibitory synapse. Is active in GABA-ergic synapse and glutamatergic synapse. Is expressed in testis. Orthologous to human RIMS2 (regulating synaptic membrane exocytosis 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in cerebellum adult (RPKM 7.7), cortex adult (RPKM 5.5) and 7 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Rims2 in Genome Data Viewer
    Location:
    15 B3.1; 15 15.45 cM
    Exon count:
    38
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (39061681..39547768)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (39198286..39684372)

    Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr15:38944202-38944502 Neighboring gene STARR-seq mESC enhancer starr_38473 Neighboring gene STARR-seq mESC enhancer starr_38474 Neighboring gene DDB1 and CUL4 associated factor 13 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene Neighboring gene STARR-seq mESC enhancer starr_38478 Neighboring gene STARR-seq mESC enhancer starr_38479 Neighboring gene STARR-seq mESC enhancer starr_38480 Neighboring gene U6 snRNA-associated Sm-like protein LSm3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_38483 Neighboring gene STARR-seq mESC enhancer starr_38487 Neighboring gene STARR-seq mESC enhancer starr_38490 Neighboring gene STARR-seq mESC enhancer starr_38492 Neighboring gene dendrocyte expressed seven transmembrane protein Neighboring gene predicted gene 16291 Neighboring gene dihydropyrimidinase

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A Munc13/RIM/Rab3 tripartite complex: from priming to plasticity? Dulubova I, et al. EMBO J, 2005 Aug 17. PMID 16052212, Free PMC Article
    2. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice. Snyder K, et al. Exp Neurol, 2024 Apr. PMID 38218585,
    3. N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease. Wang X, et al. Transl Neurodegener, 2023 Nov 28. PMID 38012808, Free PMC Article
    4. Rim2alpha determines docking and priming states in insulin granule exocytosis. Yasuda T, et al. Cell Metab, 2010 Aug 4. PMID 20674857
    5. A presynaptic phosphosignaling hub for lasting homeostatic plasticity. Müller JA, et al. Cell Rep, 2022 Apr 19. PMID 35443170

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
      Title: Gene knockout of RNA binding motif 5 in the brain alters RIMS2 protein homeostasis in the cerebellum and Hippocampus and exacerbates behavioral deficits after a TBI in mice.
    2. N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.
      Title: N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.
    3. Here, the authors identify an essential role for the active zone protein RIM in stimulated somatodendritic dopamine release in the midbrain. In mice in which RIMs are selectively removed from dopamine neurons, action potentials failed to evoke significant somatodendritic release detected via D2 receptor-mediated currents.
      Title: RIM is essential for stimulated but not spontaneous somatodendritic dopamine release in the midbrain.
    4. RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions.
      Title: How to Make an Active Zone: Unexpected Universal Functional Redundancy between RIMs and RIM-BPs.
    5. Electrophysiological characterization of VDCC currents revealed that the suppressive effect of RIM2alpha on voltage-dependent inactivation (VDI) was stronger than that of RIM1alpha for the CaV2.1 variant containing the region encoded by exons 44 and 47.
      Title: C-terminal splice variants of P/Q-type Ca(2+) channel Ca(V)2.1 α(1) subunits are differentially regulated by Rab3-interacting molecule proteins.
    6. The function of RIM1/2 at rod ribbons is to enhance Cav1.4 channel activity, possibly through direct or indirect modulation of the channel.
      Title: RIM1/2-Mediated Facilitation of Cav1.4 Channel Opening Is Required for Ca2+-Stimulated Release in Mouse Rod Photoreceptors.
    7. RIM2alpha and RIM2beta promote a large complement of synaptic CaV1.3 Ca(2+) channels at inner hair cell presynaptic active zones and are required for normal hearing.
      Title: Rab3-interacting molecules 2α and 2β promote the abundance of voltage-gated CaV1.3 Ca2+ channels at hair cell active zones.
    8. Experiments with single Rim 1/2 gene inactivation at the large calyx of Held synapse show largely overlapping roles of the two major Rim genes in vesicle priming/docking
      Title: RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
    9. Rim2alpha is involved in Zona Pellucida dependent signaling.
      Title: RIM2α is a molecular scaffold for Zona pellucida-induced acrosome reaction.
    10. Data suggest that RIM1/2 proteins co-ordinately regulate key functions for fast transmitter release, enabling a high presynaptic Ca(2)+ channel density and vesicle docking at the active zone.
      Title: RIM determines Ca²+ channel density and vesicle docking at the presynaptic active zone.
    Submit: New GeneRIF Correction See all GeneRIFs (14)

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (6)  1 citation

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-macromolecule adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables structural constituent of presynaptic active zone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables structural constituent of presynaptic active zone IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    enables structural constituent of presynaptic active zone IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transmembrane transporter binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium ion-regulated exocytosis of neurotransmitter IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within calcium-ion regulated exocytosis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of localization in cell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within insulin secretion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in insulin secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in maintenance of presynaptic active zone structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of dendrite extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of excitatory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of inhibitory postsynaptic potential IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of calcium-dependent activation of synaptic vesicle fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of exocytosis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of synaptic vesicle exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of synaptic vesicle exocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spontaneous neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle docking IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle docking IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic vesicle priming IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic vesicle priming IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in GABA-ergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in GABA-ergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in inhibitory synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in neuron projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in photoreceptor ribbon synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic active zone cytoplasmic component ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    regulating synaptic membrane exocytosis protein 2
    Names
    RIM 2
    Rab3 interacting protein 1
    Rab3 interacting protein 2
    rab-3-interacting protein 2
    rab3-interacting protein 2
    synaptic exocytosis regulator 2
    synaptotagmin 3, related sequence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256382.1 → NP_001243311.1  regulating synaptic membrane exocytosis protein 2 isoform a

      See identical proteins and their annotated locations for NP_001243311.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
      Source sequence(s)
      AC101886, AC101935, AC114537
      Consensus CDS
      CCDS56982.1
      UniProtKB/TrEMBL
      D9HP81, Q6ZQ55
      Related
      ENSMUSP00000048719.10, ENSMUST00000042917.10
      Conserved Domains (5) summary
      cd04028
      Location:1403 → 1548
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1001 → 1101
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    2. NM_001256383.1 → NP_001243312.1  regulating synaptic membrane exocytosis protein 2 isoform b

      See identical proteins and their annotated locations for NP_001243312.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. It encodes isoform b which is shorter than isoform a.
      Source sequence(s)
      AC101886, AC101935, AC114537
      Consensus CDS
      CCDS88755.1
      UniProtKB/TrEMBL
      Q0VF51, Q6ZQ55
      Related
      ENSMUSP00000154153.2, ENSMUST00000227243.2
      Conserved Domains (4) summary
      cd04028
      Location:1381 → 1526
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:774 → 900
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:640 → 721
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 154
      PHD_SF; PHD finger superfamily

    3. NM_001256384.1 → NP_001243313.1  regulating synaptic membrane exocytosis protein 2 isoform d

      See identical proteins and their annotated locations for NP_001243313.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks most of the 5' exons, includes an alternate 5' terminal exon and maintains the reading frame, compared to variant 1. It encodes isoform d which is shorter than isoform a.
      Source sequence(s)
      AC114537, AK032619
      Consensus CDS
      CCDS88756.1
      UniProtKB/Swiss-Prot
      Q9EQZ7
      Related
      ENSMUSP00000153868.2, ENSMUST00000226410.2
      Conserved Domains (1) summary
      cd04028
      Location:116 → 261
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins

    4. NM_053271.2 → NP_444501.1  regulating synaptic membrane exocytosis protein 2 isoform c

      See identical proteins and their annotated locations for NP_444501.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has multiple differences in the coding region but maintains the reading frame, compared to variant 1. It encodes isoform c which is shorter than isoform a.
      Source sequence(s)
      AB021131, AK032619, BY242489
      Consensus CDS
      CCDS37067.1
      UniProtKB/Swiss-Prot
      Q8C433, Q8CCK2, Q9EQZ7
      Related
      ENSMUSP00000080711.6, ENSMUST00000082054.12
      Conserved Domains (4) summary
      cd04028
      Location:1361 → 1506
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:814 → 940
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:680 → 761
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:30 → 194
      PHD_SF; PHD finger superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000081.7 Reference GRCm39 C57BL/6J

      Range
      39061681..39547768
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017316372.2 → XP_017171861.1  regulating synaptic membrane exocytosis protein 2 isoform X4

      Conserved Domains (5) summary
      cd04028
      Location:1453 → 1598
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:780 → 903
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1013 → 1114
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:627 → 708
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    2. XM_036159081.1 → XP_036014974.1  regulating synaptic membrane exocytosis protein 2 isoform X12

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1417 → 1562
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:780 → 903
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1004 → 1104
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:627 → 708
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    3. XM_036159079.1 → XP_036014972.1  regulating synaptic membrane exocytosis protein 2 isoform X5

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1437 → 1582
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:761 → 887
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:997 → 1098
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:627 → 708
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    4. XM_017316375.2 → XP_017171864.1  regulating synaptic membrane exocytosis protein 2 isoform X9

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1428 → 1573
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:761 → 887
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:988 → 1089
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:627 → 708
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    5. XM_036159082.1 → XP_036014975.1  regulating synaptic membrane exocytosis protein 2 isoform X15

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1405 → 1550
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:761 → 887
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:627 → 708
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    6. XM_017316373.2 → XP_017171862.1  regulating synaptic membrane exocytosis protein 2 isoform X6

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1433 → 1578
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:760 → 883
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:993 → 1094
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    7. XM_017316374.2 → XP_017171863.1  regulating synaptic membrane exocytosis protein 2 isoform X7

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1432 → 1577
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:760 → 883
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:993 → 1093
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    8. XM_036159080.1 → XP_036014973.1  regulating synaptic membrane exocytosis protein 2 isoform X10

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1423 → 1568
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:760 → 883
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:984 → 1084
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    9. XM_030248287.1 → XP_030104147.1  regulating synaptic membrane exocytosis protein 2 isoform X13

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1417 → 1562
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:741 → 867
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:977 → 1078
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    10. XM_017316380.2 → XP_017171869.1  regulating synaptic membrane exocytosis protein 2 isoform X14

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1407 → 1552
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:741 → 867
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:968 → 1068
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:607 → 688
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    11. XM_017316370.2 → XP_017171859.1  regulating synaptic membrane exocytosis protein 2 isoform X1

      Conserved Domains (5) summary
      cd04028
      Location:1480 → 1625
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:807 → 930
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1040 → 1141
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:654 → 735
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    12. XM_017316371.2 → XP_017171860.1  regulating synaptic membrane exocytosis protein 2 isoform X3

      Conserved Domains (5) summary
      cd04028
      Location:1464 → 1609
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:788 → 914
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1024 → 1125
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:654 → 735
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl22851
      Location:118 → 168
      PHD_SF; PHD finger superfamily

    13. XM_030248286.1 → XP_030104146.1  regulating synaptic membrane exocytosis protein 2 isoform X8

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1429 → 1574
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 879
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:989 → 1090
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:603 → 684
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:118 → 162
      FYVE_like_SF; FYVE domain like superfamily

    14. XM_017316376.2 → XP_017171865.1  regulating synaptic membrane exocytosis protein 2 isoform X11

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1419 → 1564
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:756 → 879
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:980 → 1080
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:603 → 684
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:118 → 162
      FYVE_like_SF; FYVE domain like superfamily

    15. XM_030248285.1 → XP_030104145.1  regulating synaptic membrane exocytosis protein 2 isoform X2

      Conserved Domains (5) summary
      cd04028
      Location:1476 → 1621
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:803 → 926
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:1036 → 1137
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:650 → 731
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl28890
      Location:118 → 162
      FYVE_like_SF; FYVE domain like superfamily

    16. XM_017316385.3 → XP_017171874.1  regulating synaptic membrane exocytosis protein 2 isoform X19

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1247 → 1392
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:574 → 697
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:807 → 908
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:421 → 502
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    17. XM_017316401.3 → XP_017171890.1  regulating synaptic membrane exocytosis protein 2 isoform X33

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1028 → 1173
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:574 → 697
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:798 → 898
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:421 → 502
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    18. XM_017316403.3 → XP_017171892.1  regulating synaptic membrane exocytosis protein 2 isoform X35

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1021 → 1166
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:555 → 681
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:791 → 891
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:421 → 502
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    19. XM_036159089.1 → XP_036014982.1  regulating synaptic membrane exocytosis protein 2 isoform X40

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:999 → 1144
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:555 → 681
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:421 → 502
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    20. XM_017316405.3 → XP_017171894.1  regulating synaptic membrane exocytosis protein 2 isoform X37

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1012 → 1157
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:555 → 681
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:782 → 882
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:421 → 502
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    21. XM_017316387.3 → XP_017171876.1  regulating synaptic membrane exocytosis protein 2 isoform X20

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1227 → 1372
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:787 → 888
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    22. XM_030248298.2 → XP_030104158.1  regulating synaptic membrane exocytosis protein 2 isoform X43

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:987 → 1132
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:680 → 922
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    23. XM_036159088.1 → XP_036014981.1  regulating synaptic membrane exocytosis protein 2 isoform X38

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1008 → 1153
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:778 → 878
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    24. XM_017316410.3 → XP_017171899.1  regulating synaptic membrane exocytosis protein 2 isoform X44

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:986 → 1131
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:680 → 921
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    25. XM_030248300.2 → XP_030104160.1  regulating synaptic membrane exocytosis protein 2 isoform X48

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:926 → 1071
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:554 → 677
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    26. XM_017316389.3 → XP_017171878.1  regulating synaptic membrane exocytosis protein 2 isoform X21

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1211 → 1356
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:771 → 872
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    27. XM_030248292.2 → XP_030104152.1  regulating synaptic membrane exocytosis protein 2 isoform X22

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1210 → 1355
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:771 → 871
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    28. XM_017316407.3 → XP_017171896.1  regulating synaptic membrane exocytosis protein 2 isoform X39

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1001 → 1146
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:771 → 871
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    29. XM_036159085.1 → XP_036014978.1  regulating synaptic membrane exocytosis protein 2 isoform X25

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:1188 → 1333
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    30. XM_036159090.1 → XP_036014983.1  regulating synaptic membrane exocytosis protein 2 isoform X45

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:979 → 1124
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    31. XM_030248293.2 → XP_030104153.1  regulating synaptic membrane exocytosis protein 2 isoform X23

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1202 → 1347
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:762 → 863
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    32. XM_017316409.3 → XP_017171898.1  regulating synaptic membrane exocytosis protein 2 isoform X41

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      TIGR00934
      Location:659 → 934
      2a38euk; potassium uptake protein, Trk family
      cd04028
      Location:993 → 1138
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:762 → 863
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    33. XM_030248296.2 → XP_030104156.1  regulating synaptic membrane exocytosis protein 2 isoform X28

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1154 → 1299
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:664 → 896
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    34. XM_030248299.2 → XP_030104159.1  regulating synaptic membrane exocytosis protein 2 isoform X46

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:971 → 1116
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:664 → 906
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    35. XM_030248301.2 → XP_030104161.1  regulating synaptic membrane exocytosis protein 2 isoform X49

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:911 → 1056
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    36. XM_030248294.2 → XP_030104154.1  regulating synaptic membrane exocytosis protein 2 isoform X24

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1190 → 1335
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:730 → 935
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    37. XM_017316397.3 → XP_017171886.1  regulating synaptic membrane exocytosis protein 2 isoform X27

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1164 → 1309
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:730 → 935
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    38. XM_006520343.5 → XP_006520406.1  regulating synaptic membrane exocytosis protein 2 isoform X42

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:992 → 1137
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:762 → 862
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    39. XM_030248295.2 → XP_030104155.1  regulating synaptic membrane exocytosis protein 2 isoform X26

      UniProtKB/TrEMBL
      Q6ZQ55
      Related
      ENSMUSP00000154531.2, ENSMUST00000227381.2
      Conserved Domains (3) summary
      cd04028
      Location:1179 → 1324
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    40. XM_036159086.1 → XP_036014979.1  regulating synaptic membrane exocytosis protein 2 isoform X29

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1142 → 1287
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:664 → 904
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    41. XM_017316412.3 → XP_017171901.1  regulating synaptic membrane exocytosis protein 2 isoform X47

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:970 → 1115
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:535 → 661
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:664 → 905
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:401 → 482
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    42. XM_036159083.1 → XP_036014976.1  regulating synaptic membrane exocytosis protein 2 isoform X16

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1274 → 1419
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:601 → 724
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:834 → 935
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    43. XM_017316399.3 → XP_017171888.1  regulating synaptic membrane exocytosis protein 2 isoform X30

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1064 → 1209
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:601 → 724
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:834 → 934
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    44. XM_036159084.1 → XP_036014977.1  regulating synaptic membrane exocytosis protein 2 isoform X17

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1258 → 1403
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:818 → 919
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    45. XM_017316400.3 → XP_017171889.1  regulating synaptic membrane exocytosis protein 2 isoform X31

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      cd04028
      Location:1048 → 1193
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:818 → 918
      PHA02666; hypothetical protein; Provisional
      PHA03307
      Location:786 → 997
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    46. XM_036159087.1 → XP_036014980.1  regulating synaptic membrane exocytosis protein 2 isoform X34

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (3) summary
      cd04028
      Location:1026 → 1171
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    47. XM_030248297.2 → XP_030104157.1  regulating synaptic membrane exocytosis protein 2 isoform X32

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (5) summary
      TIGR00934
      Location:706 → 981
      2a38euk; potassium uptake protein, Trk family
      cd04028
      Location:1040 → 1185
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:809 → 910
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    48. XM_017316404.3 → XP_017171893.1  regulating synaptic membrane exocytosis protein 2 isoform X36

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1018 → 1163
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA03307
      Location:711 → 953
      PHA03307; transcriptional regulator ICP4; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

    49. XM_017316384.3 → XP_017171873.1  regulating synaptic membrane exocytosis protein 2 isoform X18

      UniProtKB/TrEMBL
      Q6ZQ55
      Conserved Domains (4) summary
      cd04028
      Location:1248 → 1393
      C2B_RIM1alpha; C2 domain second repeat contained in Rab3-interacting molecule (RIM) proteins
      cd04031
      Location:582 → 708
      C2A_RIM1alpha; C2 domain first repeat contained in Rab3-interacting molecule (RIM) proteins
      PHA02666
      Location:809 → 909
      PHA02666; hypothetical protein; Provisional
      cd00992
      Location:448 → 529
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9EQZ7.1 GenPept UniProtKB/Swiss-Prot:Q9EQZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools