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    Nlrp4c NLR family, pyrin domain containing 4C [ Mus musculus (house mouse) ]

    Gene ID: 83564, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Nlrp4cprovided by MGI
    Official Full Name
    NLR family, pyrin domain containing 4Cprovided by MGI
    Primary source
    MGI:MGI:1890518
    See related
    Ensembl:ENSMUSG00000034690 AllianceGenome:MGI:1890518
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rnh2; Nalp4c; Nalp-alpha
    Summary
    Predicted to enable molecular adaptor activity. Predicted to be involved in negative regulation of innate immune response and regulation of inflammatory response. Predicted to be active in cytoplasm. Is expressed in gonad and nervous system. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Nlrp4c in Genome Data Viewer
    Location:
    7 A1; 7 3.5 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6048160..6108148)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6045161..6105149)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene RIKEN cDNA 4933402C05 gene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 18758 Neighboring gene zinc finger protein 787 Neighboring gene STARR-positive B cell enhancer ABC_E9284 Neighboring gene predicted gene, 36371

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family. Horikawa M, et al. Biol Reprod, 2005 Apr. PMID 15590904
    2. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
    3. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Shin YH, et al. PLoS Genet, 2010 Nov 4. PMID 21079677, Free PMC Article
    4. An abundance of X-linked genes expressed in spermatogonia. Wang PJ, et al. Nat Genet, 2001 Apr. PMID 11279525
    5. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    NACHT, LRR and PYD domains-containing protein 4C
    Names
    NACHT, leucine rich repeat and PYD containing 4C
    VNACHT, leucine rich repeat and PYD containing 4C
    ribonuclease/angiogenin inhibitor 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031389.2 → NP_113566.2  NACHT, LRR and PYD domains-containing protein 4C

      See identical proteins and their annotated locations for NP_113566.2

      Status: VALIDATED

      Source sequence(s)
      AK166817, AY596194
      Consensus CDS
      CCDS51988.1
      UniProtKB/Swiss-Prot
      Q3TKR3, Q66X27
      Related
      ENSMUSP00000046503.6, ENSMUST00000037728.13
      Conserved Domains (5) summary
      COG4886
      Location:742 → 960
      LRR; Leucine-rich repeat (LRR) protein [Transcription]
      cd00116
      Location:689 → 953
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      cd08320
      Location:10 → 92
      Pyrin_NALPs; Pyrin death domain found in NALP proteins
      sd00033
      Location:749 → 776
      LRR_RI; leucine-rich repeat [structural motif]
      pfam05729
      Location:148 → 317
      NACHT; NACHT domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      6048160..6108148
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3TKR3.1 GenPept UniProtKB/Swiss-Prot:Q3TKR3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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