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    CYP3A4 cytochrome P450 family 3 subfamily A member 4 [ Pan troglodytes (chimpanzee) ]

    Gene ID: 463582, updated on 17-Aug-2024

    Summary

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    Official Symbol
    CYP3A4provided by VGNC
    Official Full Name
    cytochrome P450 family 3 subfamily A member 4provided by VGNC
    Primary source
    VGNC:VGNC:13644
    Locus tag
    CK820_G0047467
    See related
    Ensembl:ENSPTRG00000033773
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Pan troglodytes
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
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    Genomic context

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    See CYP3A4 in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2) 6 NC_072404.2 (109228920..109255915, complement)
    RS_2023_04 previous assembly NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1) 7 NC_072405.1 (105575720..105602682, complement)

    Chromosome 6 - NC_072404.2Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 3, subfamily A, polypeptide 67 Neighboring gene cytochrome P450 3A7 Neighboring gene cytochrome P450 subfamily IIIA polypeptide 43 Neighboring gene olfactory receptor family 2 subfamily AE member 1 Neighboring gene tripartite motif containing 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CYP3 phylogenomics: evidence for positive selection of CYP3A4 and CYP3A7. Qiu H, et al. Pharmacogenet Genomics, 2008 Jan. PMID 18216722
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables iron ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables testosterone 6-beta-hydroxylase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in oxidative demethylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cytochrome P450 family 3 subfamily A member 4
    Names
    cytochrome P450, family 3, subfamily A, polypeptide 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001122775.1 → NP_001116247.1  cytochrome P450 family 3 subfamily A member 4

      See identical proteins and their annotated locations for NP_001116247.1

      Status: PROVISIONAL

      Source sequence(s)
      EF589797
      UniProtKB/TrEMBL
      A0A2I3SYU7, A0A2J8Q0F2, A0A6D2XJ66, B1NL93
      Related
      ENSPTRP00000045445.5, ENSPTRT00000049146.6
      Conserved Domains (1) summary
      pfam00067
      Location:39 → 493
      p450; Cytochrome P450

    RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

    Genomic

    1. NC_072404.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

      Range
      109228920..109255915 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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