U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Tmcc3 transmembrane and coiled coil domains 3 [ Mus musculus (house mouse) ]

    Gene ID: 319880, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Tmcc3provided by MGI
    Official Full Name
    transmembrane and coiled coil domains 3provided by MGI
    Primary source
    MGI:MGI:2442900
    See related
    Ensembl:ENSMUSG00000020023 AllianceGenome:MGI:2442900
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Tmcc1; Gm1556; A230066D03Rik; C630016B22Rik
    Summary
    Predicted to enable 14-3-3 protein binding activity and identical protein binding activity. Predicted to be located in endoplasmic reticulum. Predicted to be active in endomembrane system. Is expressed in several structures, including embryo mesenchyme; epithelium; forebrain; genitourinary system; and trigeminal ganglion. Orthologous to human TMCC3 (transmembrane and coiled-coil domain family 3). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in lung adult (RPKM 15.1), colon adult (RPKM 12.4) and 26 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Tmcc3 in Genome Data Viewer
    Location:
    10 C2; 10 48.88 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (94147544..94426816)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (94311682..94590954)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93697972-93698081 Neighboring gene predicted gene, 32749 Neighboring gene STARR-seq mESC enhancer starr_27596 Neighboring gene predicted gene 4792 Neighboring gene STARR-positive B cell enhancer ABC_E5170 Neighboring gene STARR-positive B cell enhancer ABC_E6905 Neighboring gene STARR-positive B cell enhancer ABC_E6906 Neighboring gene STARR-positive B cell enhancer mm9_chr10:93889083-93889384 Neighboring gene STARR-seq mESC enhancer starr_27599 Neighboring gene predicted gene, 32827 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:93986454-93986871 Neighboring gene predicted gene, 40743 Neighboring gene STARR-positive B cell enhancer ABC_E6908 Neighboring gene STARR-seq mESC enhancer starr_27602 Neighboring gene VISTA enhancer mm280 Neighboring gene STARR-seq mESC enhancer starr_27603 Neighboring gene STARR-positive B cell enhancer ABC_E8361 Neighboring gene microRNA 7211 Neighboring gene STARR-positive B cell enhancer ABC_E10637 Neighboring gene predicted gene, 32898 Neighboring gene predicted gene, 48658

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Expression and characterization of transmembrane and coiled-coil domain family 3. Sohn WJ, et al. BMB Rep, 2016 Nov. PMID 27697108, Free PMC Article
    2. A genomic atlas of mouse hypothalamic development. Shimogori T, et al. Nat Neurosci, 2010 Jun. PMID 20436479, Free PMC Article
    3. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    4. Ex vivo Quantitative Proteomic Analysis of Serotonin Transporter Interactome: Network Impact of the SERT Ala56 Coding Variant. Quinlan MA, et al. Front Mol Neurosci, 2020. PMID 32581705, Free PMC Article
    5. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC30586

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endomembrane system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    transmembrane and coiled-coil domain protein 3
    Names
    transmembrane and coiled coil domains 1
    transmembrane and coiled-coil domains protein 3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001168684.1 → NP_001162155.1  transmembrane and coiled-coil domain protein 3 isoform b

      See identical proteins and their annotated locations for NP_001162155.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AC165338, AK132545
      Consensus CDS
      CCDS48675.1
      UniProtKB/TrEMBL
      Q8C538
      Related
      ENSMUSP00000113122.2, ENSMUST00000121471.8
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. NM_001359760.1 → NP_001346689.1  transmembrane and coiled-coil domain protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AK132545, BY122966, DV644958
      Consensus CDS
      CCDS48675.1
      UniProtKB/TrEMBL
      Q8C538
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. NM_001359761.1 → NP_001346690.1  transmembrane and coiled-coil domain protein 3 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AC133210, AK079611, AK132545, BY122966, DV644958
      Consensus CDS
      CCDS48675.1
      UniProtKB/TrEMBL
      Q8C538
      Related
      ENSMUSP00000112669.2, ENSMUST00000117460.8
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    4. NM_001359762.1 → NP_001346691.1  transmembrane and coiled-coil domain protein 3 isoform c

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (c) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC133210, AK038827, AK132545, BY122966, BY130399, DV644958
      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    5. NM_172051.3 → NP_742048.2  transmembrane and coiled-coil domain protein 3 isoform a

      See identical proteins and their annotated locations for NP_742048.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a).
      Source sequence(s)
      AK132545, BB619673
      Consensus CDS
      CCDS24134.1
      UniProtKB/Swiss-Prot
      Q501N6, Q8R310
      UniProtKB/TrEMBL
      Q8C440
      Related
      ENSMUSP00000063264.6, ENSMUST00000065060.12
      Conserved Domains (1) summary
      pfam10267
      Location:69 → 463
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    6. NM_177026.1 → NP_796000.1  transmembrane and coiled-coil domain protein 3 isoform b

      See identical proteins and their annotated locations for NP_796000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2, 3 4 and 6 encode the same isoform (b).
      Source sequence(s)
      AK132545, BY145366
      Consensus CDS
      CCDS48675.1
      UniProtKB/TrEMBL
      Q8C538
      Related
      ENSMUSP00000112401.2, ENSMUST00000117929.2
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      94147544..94426816
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245121.1 → XP_030100981.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    2. XM_036155815.1 → XP_036011708.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    3. XM_011243475.4 → XP_011241777.1  transmembrane and coiled-coil domain protein 3 isoform X2

      See identical proteins and their annotated locations for XP_011241777.1

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    4. XM_036155816.1 → XP_036011709.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    5. XM_030245122.1 → XP_030100982.1  transmembrane and coiled-coil domain protein 3 isoform X2

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:49 → 447
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    6. XM_036155814.1 → XP_036011707.1  transmembrane and coiled-coil domain protein 3 isoform X1

      UniProtKB/TrEMBL
      Q8C440
      Conserved Domains (1) summary
      pfam10267
      Location:65 → 504
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein

    7. XM_006513754.5 → XP_006513817.1  transmembrane and coiled-coil domain protein 3 isoform X3

      See identical proteins and their annotated locations for XP_006513817.1

      UniProtKB/TrEMBL
      Q8C538
      Conserved Domains (1) summary
      pfam10267
      Location:34 → 432
      Tmemb_cc2; Predicted transmembrane and coiled-coil 2 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R310.2 GenPept UniProtKB/Swiss-Prot:Q8R310

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools