egg-4 Inactive protein-tyrosine phosphatase egg-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: egg-4
Official Full Name: Inactive protein-tyrosine phosphatase egg-4
Primary source: WormBase:WBGene00020652
Locus tag: CELE_T21E3.1
See related: AllianceGenome:WB:WBGene00020652
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein kinase binding activity and protein kinase inhibitor activity. Involved in several processes, including eggshell formation; polar body extrusion after meiotic divisions; and positive regulation of protein localization to cell cortex. Located in cell cortex and nucleus. Is expressed in germ line and oocyte. Orthologous to human PTPRG (protein tyrosine phosphatase receptor type G) and PTPRZ1 (protein tyrosine phosphatase receptor type Z1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See egg-4 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 5

Sequence:: Chromosome: I; NC_003279.8 (3932210..3934813)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EGG-4 and EGG-5 are not only required for critical events of the oocyte-to-embryo transition but also link the dynamics of the regulatory machinery with the advancing cell cycle.
Title: EGG-4 and EGG-5 Link Events of the Oocyte-to-Embryo Transition with Meiotic Progression in C. elegans.
The pseudotyrosine phosphatases EGG-4 and EGG-5 sequester activated MBK-2 until the meiotic divisions by binding to the YTY motif and inhibiting MBK-2's kinase activity directly.
Title: Regulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transition.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R12E2.10 (e-PCR)
- UniSTS:311593

T21E3.2 (e-PCR)
- UniSTS:317116

T21E3.1 (e-PCR)
- UniSTS:306622

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cortical actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in eggshell formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in polar body extrusion after meiotic divisions	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein localization to cell cortex	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Inactive protein-tyrosine phosphatase egg-4

NP_491269.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

3932210..3934813

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058868.8 → NP_491269.1 Inactive protein-tyrosine phosphatase egg-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491269.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O01767

Conserved Domains (1) summary

smart00194
Location:407 → 660

PTPc; Protein tyrosine phosphatase, catalytic domain