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    cls-1 Protein CLASP-1 [ Caenorhabditis elegans ]

    Gene ID: 176064, updated on 2-Nov-2024

    Summary

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    Official Symbol
    cls-1
    Official Full Name
    Protein CLASP-1
    Primary source
    WormBase:WBGene00015580
    Locus tag
    CELE_C07H6.3
    See related
    AllianceGenome:WB:WBGene00015580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable microtubule binding activity. Involved in microtubule cytoskeleton organization and positive regulation of microtubule depolymerization. Predicted to be located in cytoplasm and microtubule. Predicted to be active in basal cortex; kinetochore; and microtubule cytoskeleton. Is expressed in several structures, including nervous system; pharyngeal-intestinal valve; pharynx; rectal gland cell; and reproductive system. Orthologous to several human genes including CLASP2 (cytoplasmic linker associated protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See cls-1 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    16
    Sequence:
    Chromosome: III; NC_003281.10 (7508178..7515285)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class Z Neighboring gene U2 snRNP-associated SURP motif-containing protein Neighboring gene Telomere length regulation protein clk-2 Neighboring gene RRM domain-containing protein Neighboring gene E3 ubiquitin-protein ligase PPP1R11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP. Al-Bassam J, et al. Trends Cell Biol, 2011 Oct. PMID 21782439, Free PMC Article
    2. Chromatids segregate without centrosomes during Caenorhabditis elegans mitosis in a Ran- and CLASP-dependent manner. Nahaboo W, et al. Mol Biol Cell, 2015 Jun 1. PMID 25833711, Free PMC Article
    3. CLASPs function redundantly to regulate astral microtubules in the C. elegans embryo. Espiritu EB, et al. Dev Biol, 2012 Aug 15. PMID 22613359, Free PMC Article
    4. In situ imaging in C. elegans reveals developmental regulation of microtubule dynamics. Lacroix B, et al. Dev Cell, 2014 Apr 28. PMID 24780738, Free PMC Article
    5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in astral microtubule organization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in establishment of mitotic spindle localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of mitotic spindle localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of microtubule depolymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of microtubule polymerization or depolymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of supramolecular fiber organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in spindle elongation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in basal cortex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasmic microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule organizing center IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Protein CLASP-1
    NP_498649.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      7508178..7515285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_066248.5 → NP_498649.1  Protein CLASP-1 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498649.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q95YF0
      Conserved Domains (1) summary
      pfam12348
      Location:379 → 591
      CLASP_N; CLASP N terminal
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95YF0.1

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