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    RBFOX2 RNA binding fox-1 homolog 2 [ Homo sapiens (human) ]

    Gene ID: 23543, updated on 2-Nov-2024

    Summary

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    Official Symbol
    RBFOX2provided by HGNC
    Official Full Name
    RNA binding fox-1 homolog 2provided by HGNC
    Primary source
    HGNC:HGNC:9906
    See related
    Ensembl:ENSG00000100320 MIM:612149; AllianceGenome:HGNC:9906
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RTA; fxh; FOX2; RBM9; Fox-2; HNRBP2; HRNBP2; dJ106I20.3
    Summary
    This gene is one of several human genes similar to the C. elegans gene Fox-1. This gene encodes an RNA binding protein that is thought to be a key regulator of alternative exon splicing in the nervous system and other cell types. The protein binds to a conserved UGCAUG element found downstream of many alternatively spliced exons and promotes inclusion of the alternative exon in mature transcripts. The protein also interacts with the estrogen receptor 1 transcription factor and regulates estrogen receptor 1 transcriptional activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in endometrium (RPKM 22.3), ovary (RPKM 20.4) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See RBFOX2 in Genome Data Viewer
    Location:
    22q12.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (35738736..36028824, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (36198484..36488569, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (36134783..36424872, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein S16 pseudogene 3 Neighboring gene apolipoprotein L5 Neighboring gene ribosomal protein L41 pseudogene 3 Neighboring gene H3K27ac hESC enhancer GRCh37_chr22:36278945-36279446 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36312425-36313104 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13660 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr22:36431275-36432018 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:36448074-36449273 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36481448-36482174 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36512656-36513156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36513157-36513657 Neighboring gene Sharpr-MPRA regulatory region 8708 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36528024-36528524 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr22:36530251-36531450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36537001-36537502 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:36537503-36538002 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:36552799-36553402 Neighboring gene NANOG hESC enhancer GRCh37_chr22:36557722-36558295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18916 Neighboring gene apolipoprotein L3 Neighboring gene MT-CO1 pseudogene 20

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing. Maurin M, et al. Nat Commun, 2023 Dec 19. PMID 38114498, Free PMC Article
    2. Alternative splicing induces cytoplasmic localization of RBFOX2 protein in calcific tendinopathy. Cho N, et al. Exp Mol Pathol, 2019 Aug. PMID 31128090
    3. Rbfox proteins regulate microRNA biogenesis by sequence-specific binding to their precursors and target downstream Dicer. Chen Y, et al. Nucleic Acids Res, 2016 May 19. PMID 27001519, Free PMC Article
    4. RBFOX2 is an important regulator of mesenchymal tissue-specific splicing in both normal and cancer tissues. Venables JP, et al. Mol Cell Biol, 2013 Jan. PMID 23149937, Free PMC Article
    5. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer. Jbara A, et al. Nature, 2023 May. PMID 36949200, Free PMC Article

    See all (141) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
      Title: RBFOX2 deregulation promotes pancreatic cancer progression and metastasis through alternative splicing.
    2. FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
      Title: FBXO7 Confers Mesenchymal Properties and Chemoresistance in Glioblastoma by Controlling Rbfox2-Mediated Alternative Splicing.
    3. RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.
      Title: RBFOX2 confers tumor growth by PI3K/AKT and MAPK signaling in gastric cancer.
    4. RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
      Title: RBFOX2 modulates a metastatic signature of alternative splicing in pancreatic cancer.
    5. The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
      Title: The Role of Alternative Splicing Factors hnRNP G and Fox-2 in the Progression and Prognosis of Esophageal Cancer.
    6. The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
      Title: The Splicing of the Mitochondrial Calcium Uniporter Genuine Activator MICU1 Is Driven by RBFOX2 Splicing Factor during Myogenic Differentiation.
    7. Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
      Title: Alternative Splicing of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Is Regulated by RBFOX2 in Lymphoid Malignancies.
    8. RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
      Title: RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
    9. Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
      Title: Alternative microexon splicing by RBFOX2 and PTBP1 is associated with metastasis in colorectal cancer.
    10. SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
      Title: SON drives oncogenic RNA splicing in glioblastoma by regulating PTBP1/PTBP2 switching and RBFOX2 activity.
    Submit: New GeneRIF Correction See all GeneRIFs (43)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA binding HDA PubMed 
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription corepressor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of cell population proliferation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    RNA binding protein fox-1 homolog 2
    Names
    RNA binding protein, fox-1 homolog 2
    RNA-binding motif protein 9
    fox-1 homolog B
    fox-1 homologue
    hexaribonucleotide-binding protein 2
    repressor of tamoxifen transcriptional activity

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029628.2 RefSeqGene

      Range
      5000..295088
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001031695.4 → NP_001026865.1  RNA binding protein fox-1 homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_001026865.1

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL049748, BC025281, DA493176
      Consensus CDS
      CCDS46700.1
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Related
      ENSP00000391670.2, ENST00000449924.6
      Conserved Domains (3) summary
      cd12407
      Location:111 → 186
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:255 → 352
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:95 → 261
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    2. NM_001082576.3 → NP_001076045.1  RNA binding protein fox-1 homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001076045.1

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL049748, CR456559, DA493176
      Consensus CDS
      CCDS46701.1
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Related
      ENSP00000405651.2, ENST00000416721.6
      Conserved Domains (3) summary
      TIGR01645
      Location:95 → 247
      half-pint; poly-U binding splicing factor, half-pint family
      pfam12414
      Location:251 → 348
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:111 → 186
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    3. NM_001082577.3 → NP_001076046.1  RNA binding protein fox-1 homolog 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL049748, AY960684, DA493176
      Consensus CDS
      CCDS46699.1
      UniProtKB/TrEMBL
      F8WSN4
      Related
      ENSP00000407855.2, ENST00000414461.6
      Conserved Domains (3) summary
      COG0724
      Location:70 → 195
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:111 → 186
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:255 → 303
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    4. NM_001082578.4 → NP_001076047.2  RNA binding protein fox-1 homolog 2 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      Consensus CDS
      CCDS43013.1
      UniProtKB/TrEMBL
      A0A0G2JRA5
      Related
      ENSP00000413035.2, ENST00000438146.7
      Conserved Domains (3) summary
      TIGR01645
      Location:166 → 332
      half-pint; poly-U binding splicing factor, half-pint family
      pfam12414
      Location:326 → 423
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    5. NM_001082579.3 → NP_001076048.2  RNA binding protein fox-1 homolog 2 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (3) summary
      TIGR01645
      Location:165 → 331
      half-pint; poly-U binding splicing factor, half-pint family
      pfam12414
      Location:325 → 422
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:181 → 256
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    6. NM_001349982.2 → NP_001336911.1  RNA binding protein fox-1 homolog 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL035800, AL049748, CR456559, DA776762, HY155887, HY351263
      UniProtKB/TrEMBL
      B0QYY4
      Conserved Domains (3) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:273 → 330
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:117 → 269
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    7. NM_001349983.2 → NP_001336912.1  RNA binding protein fox-1 homolog 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL049748, CN399960, CR456559, HY351263
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      cd12407
      Location:111 → 186
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:251 → 308
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:95 → 247
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    8. NM_001349989.2 → NP_001336918.1  RNA binding protein fox-1 homolog 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (3) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:277 → 374
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:117 → 283
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    9. NM_001349990.2 → NP_001336919.1  RNA binding protein fox-1 homolog 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (3) summary
      TIGR01645
      Location:117 → 269
      half-pint; poly-U binding splicing factor, half-pint family
      pfam12414
      Location:273 → 370
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    10. NM_001349991.2 → NP_001336920.1  RNA binding protein fox-1 homolog 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:277 → 334
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:117 → 283
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    11. NM_001349992.2 → NP_001336921.1  RNA binding protein fox-1 homolog 2 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:277 → 325
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:117 → 283
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    12. NM_001349994.2 → NP_001336923.1  RNA binding protein fox-1 homolog 2 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/TrEMBL
      B0QYY4
      Conserved Domains (2) summary
      cd12407
      Location:133 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:273 → 321
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    13. NM_001349995.2 → NP_001336924.1  RNA binding protein fox-1 homolog 2 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:92 → 167
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      pfam12414
      Location:246 → 294
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl17169
      Location:133 → 172
      RRM_SF; RNA recognition motif (RRM) superfamily

    14. NM_001349996.2 → NP_001336925.1  RNA binding protein fox-1 homolog 2 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z82217
      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (2) summary
      cd12407
      Location:134 → 208
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:273 → 370
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    15. NM_001349997.2 → NP_001336926.1  RNA binding protein fox-1 homolog 2 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AK291460, AL049748
      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (3) summary
      cd12407
      Location:112 → 187
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:256 → 353
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:96 → 262
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    16. NM_001349998.2 → NP_001336927.1  RNA binding protein fox-1 homolog 2 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AB649123, AL049748, AL079295
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      cd12407
      Location:111 → 186
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:255 → 312
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:95 → 261
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    17. NM_001349999.2 → NP_001336928.2  RNA binding protein fox-1 homolog 2 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      Consensus CDS
      CCDS93157.1
      UniProtKB/TrEMBL
      A0A0G2JRA5, A0A8Q3WKT3
      Related
      ENSP00000512219.1, ENST00000695854.1
      Conserved Domains (2) summary
      pfam12414
      Location:322 → 419
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    18. NM_001394108.1 → NP_001381037.1  RNA binding protein fox-1 homolog 2 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (2) summary
      smart00360
      Location:182 → 251
      RRM; RNA recognition motif
      TIGR01648
      Location:173 → 379
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    19. NM_001394109.1 → NP_001381038.1  RNA binding protein fox-1 homolog 2 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (1) summary
      smart00360
      Location:183 → 216
      RRM; RNA recognition motif

    20. NM_001394110.1 → NP_001381039.1  RNA binding protein fox-1 homolog 2 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (2) summary
      smart00360
      Location:182 → 216
      RRM; RNA recognition motif
      COG0724
      Location:140 → 215
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    21. NM_001394111.1 → NP_001381040.1  RNA binding protein fox-1 homolog 2 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (2) summary
      smart00360
      Location:182 → 216
      RRM; RNA recognition motif
      COG0724
      Location:140 → 215
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    22. NM_001394112.1 → NP_001381041.1  RNA binding protein fox-1 homolog 2 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (2) summary
      smart00360
      Location:183 → 252
      RRM; RNA recognition motif
      TIGR01648
      Location:174 → 380
      hnRNP-R-Q; heterogeneous nuclear ribonucleoprotein R, Q family

    23. NM_001394113.1 → NP_001381042.1  RNA binding protein fox-1 homolog 2 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/Swiss-Prot
      A4F5G8, A8K5Z5, B0QYY8, B0QYY9, O43251, Q0PRL5, Q0VH35, Q5TF71, Q6IC09, Q8TD00, Q8WYB1, Q96DZ6, Q96NL7, Q9UGW4, Q9UH33
      Conserved Domains (2) summary
      pfam12414
      Location:321 → 418
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:181 → 256
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    24. NM_001394114.1 → NP_001381043.1  RNA binding protein fox-1 homolog 2 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/TrEMBL
      A0A8Q3SI75
      Conserved Domains (2) summary
      pfam12414
      Location:322 → 370
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    25. NM_001394115.1 → NP_001381044.1  RNA binding protein fox-1 homolog 2 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AL049748, AL079295, Z95114
      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (2) summary
      pfam12414
      Location:321 → 369
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cd12407
      Location:181 → 256
      RRM_FOX1_like; RNA recognition motif (RRM) found in vertebrate RNA binding protein fox-1 homologs and similar proteins

    26. NM_014309.4 → NP_055124.1  RNA binding protein fox-1 homolog 2 isoform 2

      See identical proteins and their annotated locations for NP_055124.1

      Status: REVIEWED

      Source sequence(s)
      AA610054, AL009266, AL049748, DA493176
      Consensus CDS
      CCDS13921.1
      UniProtKB/TrEMBL
      A0A8Q3SI75
      Related
      ENSP00000384944.2, ENST00000405409.6
      Conserved Domains (3) summary
      COG0724
      Location:95 → 196
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:112 → 187
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 300
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      35738736..36028824 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005261429.3 → XP_005261486.1  RNA binding protein fox-1 homolog 2 isoform X4

      UniProtKB/TrEMBL
      B0QYY4
      Conserved Domains (3) summary
      COG0724
      Location:140 → 265
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:181 → 256
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:321 → 378
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    2. XM_006724186.3 → XP_006724249.1  RNA binding protein fox-1 homolog 2 isoform X2

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:140 → 265
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:181 → 256
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:325 → 382
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    3. XM_005261430.3 → XP_005261487.1  RNA binding protein fox-1 homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:322 → 420
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    4. XM_005261428.3 → XP_005261485.1  RNA binding protein fox-1 homolog 2 isoform X3

      UniProtKB/TrEMBL
      B0QYY4
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:322 → 379
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    5. XM_006724188.3 → XP_006724251.1  RNA binding protein fox-1 homolog 2 isoform X8

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:326 → 374
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    6. XM_006724187.3 → XP_006724250.1  RNA binding protein fox-1 homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:326 → 424
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    7. XM_006724185.3 → XP_006724248.1  RNA binding protein fox-1 homolog 2 isoform X1

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:326 → 383
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    8. XM_017028686.1 → XP_016884175.1  RNA binding protein fox-1 homolog 2 isoform X7

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:107 → 208
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:124 → 199
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:268 → 325
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    9. XM_047441254.1 → XP_047297210.1  RNA binding protein fox-1 homolog 2 isoform X22

    10. XM_047441251.1 → XP_047297207.1  RNA binding protein fox-1 homolog 2 isoform X16

    11. XM_047441250.1 → XP_047297206.1  RNA binding protein fox-1 homolog 2 isoform X12

    12. XM_006724189.4 → XP_006724252.1  RNA binding protein fox-1 homolog 2 isoform X11

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:117 → 218
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:134 → 209
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:278 → 335
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    13. XM_017028687.3 → XP_016884176.1  RNA binding protein fox-1 homolog 2 isoform X9

      UniProtKB/TrEMBL
      F8WSN4

    14. XM_024452188.2 → XP_024307956.1  RNA binding protein fox-1 homolog 2 isoform X10

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      cd12407
      Location:155 → 230
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:299 → 356
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:139 → 305
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    15. XM_047441260.1 → XP_047297216.1  RNA binding protein fox-1 homolog 2 isoform X31

    16. XM_047441258.1 → XP_047297214.1  RNA binding protein fox-1 homolog 2 isoform X28

    17. XM_024452191.2 → XP_024307959.1  RNA binding protein fox-1 homolog 2 isoform X27

      UniProtKB/TrEMBL
      A8MVJ8, B0QYV1
      Conserved Domains (3) summary
      cd12407
      Location:107 → 182
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:247 → 344
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal
      cl25887
      Location:91 → 243
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]

    18. XM_047441253.1 → XP_047297209.1  RNA binding protein fox-1 homolog 2 isoform X21

      Related
      ENSP00000352328.4, ENST00000359369.8

    19. XM_047441252.1 → XP_047297208.1  RNA binding protein fox-1 homolog 2 isoform X20

    20. XM_047441259.1 → XP_047297215.1  RNA binding protein fox-1 homolog 2 isoform X30

    21. XM_006724192.3 → XP_006724255.1  RNA binding protein fox-1 homolog 2 isoform X18

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:91 → 192
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:108 → 183
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 309
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    22. XM_047441257.1 → XP_047297213.1  RNA binding protein fox-1 homolog 2 isoform X26

    23. XM_017028691.2 → XP_016884180.1  RNA binding protein fox-1 homolog 2 isoform X14

      UniProtKB/TrEMBL
      F8WSN4

    24. XM_017028690.2 → XP_016884179.1  RNA binding protein fox-1 homolog 2 isoform X13

      UniProtKB/TrEMBL
      F8WSN4

    25. XM_017028698.2 → XP_016884187.1  RNA binding protein fox-1 homolog 2 isoform X29

      UniProtKB/TrEMBL
      F8WSN4

    26. XM_047441256.1 → XP_047297212.1  RNA binding protein fox-1 homolog 2 isoform X25

    27. XM_047441255.1 → XP_047297211.1  RNA binding protein fox-1 homolog 2 isoform X23

    28. XM_017028696.2 → XP_016884185.1  RNA binding protein fox-1 homolog 2 isoform X24

      UniProtKB/TrEMBL
      A8MVJ8, B0QYV1
      Related
      ENSP00000512183.1, ENST00000695803.1
      Conserved Domains (3) summary
      TIGR01645
      Location:96 → 248
      half-pint; poly-U binding splicing factor, half-pint family
      cd12407
      Location:112 → 187
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 349
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    29. XM_017028693.2 → XP_016884182.1  RNA binding protein fox-1 homolog 2 isoform X17

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:95 → 196
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:112 → 187
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:252 → 309
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    30. XM_006724191.2 → XP_006724254.1  RNA binding protein fox-1 homolog 2 isoform X15

      UniProtKB/TrEMBL
      F8WSN4
      Conserved Domains (3) summary
      COG0724
      Location:95 → 196
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:112 → 187
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:256 → 313
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    31. XM_006724193.4 → XP_006724256.1  RNA binding protein fox-1 homolog 2 isoform X19

      UniProtKB/TrEMBL
      A0A0G2JRA5
      Conserved Domains (3) summary
      COG0724
      Location:165 → 266
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cd12407
      Location:182 → 257
      RRM_FOX1_like; RNA recognition motif in vertebrate RNA binding protein fox-1 homologs and similar proteins
      pfam12414
      Location:326 → 383
      Fox-1_C; Calcitonin gene-related peptide regulator C terminal

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187630.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      59734..259897 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      36198484..36488569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325369.1 → XP_054181344.1  RNA binding protein fox-1 homolog 2 isoform X4

    2. XM_054325367.1 → XP_054181342.1  RNA binding protein fox-1 homolog 2 isoform X2

    3. XM_054325371.1 → XP_054181346.1  RNA binding protein fox-1 homolog 2 isoform X6

    4. XM_054325368.1 → XP_054181343.1  RNA binding protein fox-1 homolog 2 isoform X3

    5. XM_054325373.1 → XP_054181348.1  RNA binding protein fox-1 homolog 2 isoform X8

    6. XM_054325370.1 → XP_054181345.1  RNA binding protein fox-1 homolog 2 isoform X5

    7. XM_054325366.1 → XP_054181341.1  RNA binding protein fox-1 homolog 2 isoform X1

    8. XM_054325372.1 → XP_054181347.1  RNA binding protein fox-1 homolog 2 isoform X7

    9. XM_054325387.1 → XP_054181362.1  RNA binding protein fox-1 homolog 2 isoform X22

    10. XM_054325381.1 → XP_054181356.1  RNA binding protein fox-1 homolog 2 isoform X16

    11. XM_054325377.1 → XP_054181352.1  RNA binding protein fox-1 homolog 2 isoform X12

    12. XM_054325376.1 → XP_054181351.1  RNA binding protein fox-1 homolog 2 isoform X11

    13. XM_054325374.1 → XP_054181349.1  RNA binding protein fox-1 homolog 2 isoform X9

    14. XM_054325375.1 → XP_054181350.1  RNA binding protein fox-1 homolog 2 isoform X10

    15. XM_054325395.1 → XP_054181370.1  RNA binding protein fox-1 homolog 2 isoform X30

    16. XM_054325383.1 → XP_054181358.1  RNA binding protein fox-1 homolog 2 isoform X18

    17. XM_054325393.1 → XP_054181368.1  RNA binding protein fox-1 homolog 2 isoform X28

    18. XM_054325396.1 → XP_054181371.1  RNA binding protein fox-1 homolog 2 isoform X31

    19. XM_054325392.1 → XP_054181367.1  RNA binding protein fox-1 homolog 2 isoform X27

    20. XM_054325386.1 → XP_054181361.1  RNA binding protein fox-1 homolog 2 isoform X21

    21. XM_054325385.1 → XP_054181360.1  RNA binding protein fox-1 homolog 2 isoform X20

    22. XM_054325391.1 → XP_054181366.1  RNA binding protein fox-1 homolog 2 isoform X26

    23. XM_054325379.1 → XP_054181354.1  RNA binding protein fox-1 homolog 2 isoform X14

    24. XM_054325378.1 → XP_054181353.1  RNA binding protein fox-1 homolog 2 isoform X13

    25. XM_054325394.1 → XP_054181369.1  RNA binding protein fox-1 homolog 2 isoform X29

    26. XM_054325390.1 → XP_054181365.1  RNA binding protein fox-1 homolog 2 isoform X25

    27. XM_054325388.1 → XP_054181363.1  RNA binding protein fox-1 homolog 2 isoform X23

    28. XM_054325389.1 → XP_054181364.1  RNA binding protein fox-1 homolog 2 isoform X24

    29. XM_054325382.1 → XP_054181357.1  RNA binding protein fox-1 homolog 2 isoform X17

    30. XM_054325380.1 → XP_054181355.1  RNA binding protein fox-1 homolog 2 isoform X15

    31. XM_054325384.1 → XP_054181359.1  RNA binding protein fox-1 homolog 2 isoform X19

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O43251.3 GenPept UniProtKB/Swiss-Prot:O43251

    Gene LinkOut

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