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    Pnpla8 patatin-like phospholipase domain containing 8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 314075, updated on 14-Nov-2024

    Summary

    Official Symbol
    Pnpla8provided by RGD
    Official Full Name
    patatin-like phospholipase domain containing 8provided by RGD
    Primary source
    RGD:1311444
    See related
    EnsemblRapid:ENSRNOG00000039091 AllianceGenome:RGD:1311444
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311444
    Summary
    Predicted to enable calcium-independent phospholipase A2 activity. Predicted to be involved in several processes, including arachidonate secretion; glycerophospholipid metabolic process; and unsaturated fatty acid metabolic process. Predicted to be located in mitochondrion and peroxisomal membrane. Predicted to be active in membrane. Orthologous to human PNPLA8 (patatin like phospholipase domain containing 8). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Muscle (RPKM 458.2), Adrenal (RPKM 448.9) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Pnpla8 in Genome Data Viewer
    Location:
    6q21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (67056783..67118714)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (61329810..61391736)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (64224870..64288465)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120103526 Neighboring gene DnaJ heat shock protein family (Hsp40) member B9 Neighboring gene DnaJ heat shock protein family (Hsp40) member B6, pseudogene 4 Neighboring gene neuronal cell adhesion molecule Neighboring gene U6 spliceosomal RNA

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Pathways from PubChem

    General gene information

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium-dependent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables calcium-independent phospholipase A2 activity  
    enables lysophospholipase activity  
    enables phospholipase A1 activity  
    enables phospholipase activity  
    Process Evidence Code Pubs
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process  
    involved_in arachidonate metabolic process  
    involved_in arachidonate secretion  
    involved_in cardiolipin metabolic process  
    involved_in cardiolipin metabolic process  
    involved_in fatty acid metabolic process  
    involved_in intracellular signal transduction  
    involved_in linoleic acid metabolic process  
    involved_in lipid catabolic process  
    involved_in lipid homeostasis  
    involved_in lipid homeostasis  
    involved_in phosphatidylcholine catabolic process  
    involved_in phosphatidylethanolamine catabolic process  
    involved_in prostaglandin biosynthetic process  
    involved_in regulation of cellular response to oxidative stress  
    involved_in triglyceride homeostasis  
    involved_in triglyceride homeostasis  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane  
    is_active_in membrane  
    located_in membrane  
    located_in membrane  
    located_in mitochondrial membrane  
    located_in mitochondrion  
    located_in mitochondrion  
    located_in peroxisomal membrane  
    located_in peroxisome  
    located_in peroxisome  

    General protein information

    Preferred Names
    calcium-independent phospholipase A2-gamma
    Names
    iPLA2-gamma
    intracellular membrane-associated calcium-independent phospholipase A2 gamma
    patatin-like phospholipase domain-containing protein 8
    NP_001101490.2
    XP_063117971.1
    XP_063117972.1
    XP_063117973.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108020.2NP_001101490.2  calcium-independent phospholipase A2-gamma

      Status: VALIDATED

      Source sequence(s)
      FQ211866, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      D3ZRC4
      UniProtKB/TrEMBL
      A0A1W2Q6C9
      Related
      ENSRNOP00000049214.3, ENSRNOT00000047296.8
      Conserved Domains (1) summary
      cd07211
      Location:429735
      Pat_PNPLA8; Patatin-like phospholipase domain containing protein 8

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      67056783..67118714
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261902.1XP_063117972.1  calcium-independent phospholipase A2-gamma isoform X2

    2. XM_063261903.1XP_063117973.1  calcium-independent phospholipase A2-gamma isoform X2

    3. XM_063261901.1XP_063117971.1  calcium-independent phospholipase A2-gamma isoform X1

      UniProtKB/Swiss-Prot
      D3ZRC4
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