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    TEX9 testis expressed 9 [ Homo sapiens (human) ]

    Gene ID: 374618, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TEX9provided by HGNC
    Official Full Name
    testis expressed 9provided by HGNC
    Primary source
    HGNC:HGNC:29585
    See related
    Ensembl:ENSG00000151575 MIM:620935; AllianceGenome:HGNC:29585
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    Located in centriolar satellite. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in testis (RPKM 5.0), thyroid (RPKM 4.2) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TEX9 in Genome Data Viewer
    Location:
    15q21.3
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (56243973..56460010)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (54046826..54262846)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (56536171..56738081)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903498 Neighboring gene Sharpr-MPRA regulatory region 1757 Neighboring gene regulatory factor X7 Neighboring gene hydroxyacyl-CoA dehydrogenase pseudogene Neighboring gene MPRA-validated peak2347 silencer Neighboring gene laforin-like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6461 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6462 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:56536049-56536694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56536695-56537340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56537341-56537986 Neighboring gene RNA, U6 small nuclear 1287, pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:56608633-56609184 Neighboring gene high mobility group box 1 pseudogene 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9453 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9455 Neighboring gene uncharacterized LOC105370832 Neighboring gene Sharpr-MPRA regulatory region 15328 Neighboring gene meiosis specific nuclear structural 1 Neighboring gene zinc finger protein 280D Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_40335 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6466

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Clozapine-induced agranulocytosis is associated with rare HLA-DQB1 and HLA-B alleles.
    EBI GWAS Catalog
    Common variants in left/right asymmetry genes and pathways are associated with relative hand skill.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC40181

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    testis-expressed protein 9
    Names
    testis-expressed sequence 9 protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001286449.2 → NP_001273378.1  testis-expressed protein 9 isoform 2

      See identical proteins and their annotated locations for NP_001273378.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' region and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      UniProtKB/Swiss-Prot
      Q8N6V9
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    2. NM_001385040.1 → NP_001371969.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. NM_001385041.1 → NP_001371970.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    4. NM_001385042.1 → NP_001371971.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Related
      ENSP00000452791.2, ENST00000560827.6
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    5. NM_001385043.1 → NP_001371972.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. NM_001385044.1 → NP_001371973.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' and 3' UTRs compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    7. NM_001385045.1 → NP_001371974.1  testis-expressed protein 9 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (8) differs in the 3' UTR compared to variant 2. Variants 2-8 all encode the same isoform (2).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS66776.1
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 273
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    8. NM_001385046.1 → NP_001371975.1  testis-expressed protein 9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:146 → 304
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. NM_001385047.1 → NP_001371976.1  testis-expressed protein 9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:190 → 328
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    10. NM_001385048.1 → NP_001371977.1  testis-expressed protein 9 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:71 → 229
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    11. NM_001385049.1 → NP_001371978.1  testis-expressed protein 9 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:115 → 224
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    12. NM_001385050.1 → NP_001371979.1  testis-expressed protein 9 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (13), as well as variants 14 and 15, encodes isoform 7.
      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 145
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    13. NM_001385051.1 → NP_001371980.1  testis-expressed protein 9 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (14), as well as variants 13 and 15, encodes isoform 7.
      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 145
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    14. NM_001385052.1 → NP_001371981.1  testis-expressed protein 9 isoform 7

      Status: VALIDATED

      Description
      Transcript Variant: This variant (15), as well as variants 13 and 14, encodes isoform 7.
      Source sequence(s)
      AC068726, AC084782
      Conserved Domains (1) summary
      TIGR02168
      Location:2 → 145
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    15. NM_001395496.1 → NP_001382425.1  testis-expressed protein 9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS10157.1
      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669
      Related
      ENSP00000512397.1, ENST00000696102.1
      Conserved Domains (1) summary
      TIGR02168
      Location:190 → 348
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    16. NM_198524.3 → NP_940926.1  testis-expressed protein 9 isoform 1

      See identical proteins and their annotated locations for NP_940926.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC068726, AC084782
      Consensus CDS
      CCDS10157.1
      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669
      Related
      ENSP00000342169.2, ENST00000352903.6
      Conserved Domains (1) summary
      TIGR02168
      Location:190 → 348
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. NR_169560.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782

    2. NR_169561.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782

    3. NR_169562.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782

    4. NR_169563.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC068726, AC084782

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      56243973..56460010
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047432470.1 → XP_047288426.1  testis-expressed protein 9 isoform X4

    2. XM_047432466.1 → XP_047288422.1  testis-expressed protein 9 isoform X1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669

    3. XM_047432468.1 → XP_047288424.1  testis-expressed protein 9 isoform X2

    4. XM_047432475.1 → XP_047288431.1  testis-expressed protein 9 isoform X5

    5. XM_011521530.4 → XP_011519832.1  testis-expressed protein 9 isoform X1

      See identical proteins and their annotated locations for XP_011519832.1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669
      Conserved Domains (1) summary
      TIGR02168
      Location:190 → 348
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    6. XM_047432476.1 → XP_047288432.1  testis-expressed protein 9 isoform X5

    7. XM_047432467.1 → XP_047288423.1  testis-expressed protein 9 isoform X2

    8. XM_005254359.6 → XP_005254416.1  testis-expressed protein 9 isoform X1

      See identical proteins and their annotated locations for XP_005254416.1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669
      Conserved Domains (1) summary
      TIGR02168
      Location:190 → 348
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    9. XM_047432474.1 → XP_047288430.1  testis-expressed protein 9 isoform X5

    10. XM_047432469.1 → XP_047288425.1  testis-expressed protein 9 isoform X3

    11. XM_047432472.1 → XP_047288428.1  testis-expressed protein 9 isoform X4

    12. XM_047432471.1 → XP_047288427.1  testis-expressed protein 9 isoform X4

    13. XM_047432473.1 → XP_047288429.1  testis-expressed protein 9 isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      54046826..54262846
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054377869.1 → XP_054233844.1  testis-expressed protein 9 isoform X4

    2. XM_054377866.1 → XP_054233841.1  testis-expressed protein 9 isoform X1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669

    3. XM_054377868.1 → XP_054233843.1  testis-expressed protein 9 isoform X2

    4. XM_054377873.1 → XP_054233848.1  testis-expressed protein 9 isoform X5

    5. XM_054377864.1 → XP_054233839.1  testis-expressed protein 9 isoform X1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669

    6. XM_054377874.1 → XP_054233849.1  testis-expressed protein 9 isoform X5

    7. XM_054377867.1 → XP_054233842.1  testis-expressed protein 9 isoform X2

    8. XM_054377865.1 → XP_054233840.1  testis-expressed protein 9 isoform X1

      UniProtKB/Swiss-Prot
      B4DH73, Q8N6V9
      UniProtKB/TrEMBL
      A0A0S2Z669

    9. XM_054377872.1 → XP_054233847.1  testis-expressed protein 9 isoform X5

    10. XM_054377870.1 → XP_054233845.1  testis-expressed protein 9 isoform X4

    11. XM_054377871.1 → XP_054233846.1  testis-expressed protein 9 isoform X4

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8N6V9.1 GenPept UniProtKB/Swiss-Prot:Q8N6V9

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