ANG angiogenin [Homo sapiens (human)] - Gene

Summary

Official Symbol: ANGprovided by HGNC
Official Full Name: angiogeninprovided by HGNC
Primary source: HGNC:HGNC:483
See related: Ensembl:ENSG00000214274 MIM:105850; AllianceGenome:HGNC:483
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ALS9; RAA1; HEL168; RNASE4; RNASE5
Summary: The protein encoded by this gene is a member of the RNase A superfamily though it has relatively weak ribonucleolytic activity. This protein is a potent mediator of new blood vessel formation and thus, in addition to the name RNase5, is commonly called angiogenin. This protein induces angiogenesis after binding to actin on the surface of endothelial cells. This protein also accumulates at the nucleolus where it stimulates ribosomal transcription. Under stress conditions this protein translocates to the cytosol where it hydrolyzes cellular tRNAs and influences protein synthesis. A signal peptide is cleaved from the precursor protein to produce a mature protein which contains a nuclear localization signal, a cell binding motif, and a catalytic domain. This protein has been shown to be both neurotrophic and neuroprotective and the mature protein has antimicrobial activity against some bacteria and fungi, including S. pneumoniae and C. albicans. Due to its effect on rRNA production and angiogenesis this gene plays important roles in cell growth and tumor progression. Mutations in this gene are associated with progression of amyotrophic lateral sclerosis (ALS). This gene and the neighboring RNase4 gene share promoters and 5' exons though each gene then splices to a distinct 3' exon containing the complete coding region of each gene. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2020]
Expression: Biased expression in liver (RPKM 449.5), ovary (RPKM 29.5) and 2 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q11.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (20684177..20694186)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (14881287..14891295)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (21152336..21162345)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural mechanism of angiogenin activation by the ribosome.
Title: Structural mechanism of angiogenin activation by the ribosome.
Long-timescale atomistic simulations uncover loss-of-function mechanisms of uncharacterized Angiogenin mutants associated with ALS.
Title: Long-timescale atomistic simulations uncover loss-of-function mechanisms of uncharacterized Angiogenin mutants associated with ALS.
Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
Title: Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor.
Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin.
Title: Neural stem cell homeostasis is affected in cortical organoids carrying a mutation in Angiogenin.
Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions.
Title: Angiogenin as a Possible Mediator of Macrophage-Mediated Regulation of Fibroblast Functions.
Non-enzymatic glycation of human angiogenin: Effects on enzymatic activity and binding to hRI and DNA.
Title: Non-enzymatic glycation of human angiogenin: Effects on enzymatic activity and binding to hRI and DNA.
Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
Title: Angiogenin and plexin-B2 axis promotes glioblastoma progression by enhancing invasion, vascular association, proliferation and survival.
Endothelial Intracellular ANG (Angiogenin) Protects Against Atherosclerosis by Decreasing Endoplasmic Reticulum Stress.
Title: Endothelial Intracellular ANG (Angiogenin) Protects Against Atherosclerosis by Decreasing Endoplasmic Reticulum Stress.
Angiogenin and MMP-2 as potential biomarkers in the differential diagnosis of gestational trophoblastic diseases.
Title: Angiogenin and MMP-2 as potential biomarkers in the differential diagnosis of gestational trophoblastic diseases.
Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells.
Title: Oxaliplatin inhibits angiogenin proliferative and cell migration effects in prostate cancer cells.

Submit: New GeneRIF Correction See all GeneRIFs (167)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Amyotrophic lateral sclerosis type 9 MedGen: C2678468 OMIM: 611895 GeneReviews: Amyotrophic Lateral Sclerosis Overview	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
HIV-1 infected clinical samples have plasma extracellular vesicles that contain elevated CCL1 (I309), IGFBP1, CCL5 (RANTES), GMCSF, ANG (Angiogenin), ADIPOQ (ACRP30), CSF3 (GCSF), CXCL1, ICAM1, IL2RA, IL6R, TNFRSF1A, and TIMP1 compared to healthy donors	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH1630 (e-PCR)
- UniSTS:79418

GDB:178381 (e-PCR)
- UniSTS:154991

D14S1338 (e-PCR)
- UniSTS:69799

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IC Inferred by Curator more info	PubMed
enables RNA endonuclease activity	TAS Traceable Author Statement more info
enables RNA nuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables RNA nuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables copper ion binding	IDA Inferred from Direct Assay more info	PubMed
enables endonuclease activity	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables peptide binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables rRNA binding	TAS Traceable Author Statement more info	PubMed
enables ribosome binding	IDA Inferred from Direct Assay more info	PubMed
enables signaling receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables tRNA-specific ribonuclease activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in actin filament polymerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in angiogenesis	TAS Traceable Author Statement more info	PubMed
involved_in antibacterial humoral response	IBA Inferred from Biological aspect of Ancestor more info
involved_in antibacterial humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antifungal humoral response	IDA Inferred from Direct Assay more info	PubMed
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IBA Inferred from Biological aspect of Ancestor more info
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide	IDA Inferred from Direct Assay more info	PubMed
involved_in cell communication	NAS Non-traceable Author Statement more info	PubMed
involved_in cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in defense response to Gram-positive bacterium	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in homeostatic process	NAS Non-traceable Author Statement more info	PubMed
involved_in innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of translation in response to stress	IDA Inferred from Direct Assay more info	PubMed
involved_in oocyte maturation	NAS Non-traceable Author Statement more info	PubMed
involved_in ovarian follicle development	NAS Non-traceable Author Statement more info	PubMed
involved_in placenta development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein secretion	ISS Inferred from Sequence or Structural Similarity more info
involved_in rRNA transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in rRNA transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hypoxia	NAS Non-traceable Author Statement more info	PubMed
involved_in response to yeast	IDA Inferred from Direct Assay more info	PubMed
involved_in signaling	IDA Inferred from Direct Assay more info	PubMed
involved_in stress granule assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in tRNA decay	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IDA Inferred from Direct Assay more info
part_of angiogenin-PRI complex	IDA Inferred from Direct Assay more info	PubMed
part_of angiogenin-PRI complex	IPI Inferred from Physical Interaction more info	PubMed
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in chromosome	IDA Inferred from Direct Assay more info
is_active_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasmic stress granule	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	ISS Inferred from Sequence or Structural Similarity more info
located_in neuronal cell body	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleolus	IDA Inferred from Direct Assay more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: angiogenin

Names: Homo sapiens epididymis luminal protein 168; RNase 5; angiogenin, ribonuclease, RNase A family, 5; epididymis luminal protein 168; ribonuclease 5; ribonuclease A A1; ribonuclease A family member 5

NP_001091046.1

EC 3.1.27.-

NP_001136.1

EC 3.1.27.-

NP_001372200.1

EC 3.1.27.-

NP_001372201.1

EC 3.1.27.-

NP_001372202.1

EC 3.1.27.-

NP_001372203.1

EC 3.1.27.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_008717.2 RefSeqGene

Range

5001..15010

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_653

mRNA and Protein(s)

NM_001097577.3 → NP_001091046.1 angiogenin precursor

See identical proteins and their annotated locations for NP_001091046.1

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Related

ENSP00000381077.4, ENST00000397990.5

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease
NM_001145.4 → NP_001136.1 angiogenin precursor

See identical proteins and their annotated locations for NP_001136.1

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Related

ENSP00000336762.6, ENST00000336811.10

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease
NM_001385271.1 → NP_001372200.1 angiogenin precursor

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease
NM_001385272.1 → NP_001372201.1 angiogenin precursor

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease
NM_001385273.1 → NP_001372202.1 angiogenin precursor

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease
NM_001385274.1 → NP_001372203.1 angiogenin precursor

Status: REVIEWED

Source sequence(s)

AL163636

Consensus CDS

CCDS9554.1

UniProtKB/Swiss-Prot

P03950, Q05CV1, Q53X86, Q6P5T2, Q8WXE7

UniProtKB/TrEMBL

W0UV28

Conserved Domains (1) summary

smart00092
Location:26 → 143

RNAse_Pc; Pancreatic ribonuclease