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    ZFP92 ZFP92 zinc finger protein [ Homo sapiens (human) ]

    Gene ID: 139735, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZFP92provided by HGNC
    Official Full Name
    ZFP92 zinc finger proteinprovided by HGNC
    Primary source
    HGNC:HGNC:12865
    See related
    Ensembl:ENSG00000189420 AllianceGenome:HGNC:12865
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF897
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Broad expression in ovary (RPKM 2.1), bone marrow (RPKM 1.1) and 19 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZFP92 in Genome Data Viewer
    Location:
    Xq28
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (153411472..153426481)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (151685065..151700072)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (152676930..152691939)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 275 Neighboring gene uncharacterized LOC105373378 Neighboring gene uncharacterized LOC105373379 Neighboring gene PNMA family member 6E Neighboring gene RNA, 7SL, cytoplasmic 667, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21061 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21062 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152677238-152677448 Neighboring gene three prime repair exonuclease 2 Neighboring gene ReSE screen-validated silencer GRCh37_chrX:152726424-152726582 Neighboring gene HAUS augmin like complex subunit 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30034 Neighboring gene Sharpr-MPRA regulatory region 9358 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152741433-152741972 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742168-152742668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:152742669-152743169 Neighboring gene extracellular matrix protein X-linked, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 92 homolog
    Names
    zinc finger protein homologous to Zfp92 in mouse

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136273.2 → NP_001129745.1  zinc finger protein 92 homolog isoform 1

      See identical proteins and their annotated locations for NP_001129745.1

      Status: VALIDATED

      Source sequence(s)
      U82695
      Consensus CDS
      CCDS59177.1
      UniProtKB/Swiss-Prot
      A6NM28
      Related
      ENSP00000462054.1, ENST00000338647.7
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:145 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:154 → 174
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:335 → 359
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001386943.1 → NP_001373872.1  zinc finger protein 92 homolog isoform 2

      Status: VALIDATED

      Source sequence(s)
      U82695
      Conserved Domains (4) summary
      COG5048
      Location:103 → 244
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:112 → 132
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:293 → 317
      zf-H2C2_2; Zinc-finger double domain
      cl02581
      Location:1 → 32
      KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

    3. NM_001386944.1 → NP_001373873.1  zinc finger protein 92 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      U82695
      Consensus CDS
      CCDS59177.1
      UniProtKB/Swiss-Prot
      A6NM28
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:145 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:154 → 174
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:335 → 359
      zf-H2C2_2; Zinc-finger double domain

    4. NM_001386945.1 → NP_001373874.1  zinc finger protein 92 homolog isoform 1

      Status: VALIDATED

      Source sequence(s)
      U82695
      Consensus CDS
      CCDS59177.1
      UniProtKB/Swiss-Prot
      A6NM28
      Conserved Domains (4) summary
      smart00349
      Location:14 → 74
      KRAB; krueppel associated box
      COG5048
      Location:145 → 286
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:154 → 174
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:335 → 359
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      153411472..153426481
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      151685065..151700072
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A6NM28.3 GenPept UniProtKB/Swiss-Prot:A6NM28

    Gene LinkOut

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