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    rep2 transcriptional activator MBF subunit Rep2 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2540341, updated on 18-Sep-2024

    Summary

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    Official Symbol
    rep2
    Official Full Name
    transcriptional activator MBF subunit Rep2
    Primary source
    PomBase:SPBC2F12.11c
    Locus tag
    SPOM_SPBC2F12.11C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
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    Genomic context

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    See rep2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_003423.3 (1717703..1719322)

    Chromosome II - NC_003423.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene cytochrome c oxidase subunit VII Cox7 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene mitochondrial ribosomal protein subunit L35 Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003423.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deconvolution of chromatin immunoprecipitation-microarray (ChIP-chip) analysis of MBF occupancies reveals the temporal recruitment of Rep2 at the MBF target genes. Eshaghi M, et al. Eukaryot Cell, 2011 Jan. PMID 21076007, Free PMC Article
    2. mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe. Mukherjee K, et al. Open Biol, 2018 Sep 26. PMID 30257894, Free PMC Article
    3. A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast. Chu Z, et al. Mol Cell Biol, 2009 Sep. PMID 19596787, Free PMC Article
    4. Functional domains of rep2, a transcriptional activator subunit for Res2-Cdc10, controlling the cell cycle "start". Tahara S, et al. Mol Biol Cell, 1998 Jun. PMID 9614195, Free PMC Article
    5. Domains determining the functional distinction of the fission yeast cell cycle "start" molecules Res1 and Res2. Sturm S, et al. Mol Biol Cell, 1996 Dec. PMID 8970158, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Gcn5-mediated acetylation at MBF-regulated promoters induces the G1-S transcriptional wave.
      Title: Gcn5-mediated acetylation at MBF-regulated promoters induces the G1/S transcriptional wave.
    2. Study found the mRNA for rep2, an important factor for transcription of vegetative S-phase transcripts rather than meiotic transcripts.
      Title: mmi1 and rep2 mRNAs are novel RNA targets of the Mei2 RNA-binding protein during early meiosis in Schizosaccharomyces pombe.
    3. MBF activator Rep2 plays a role in mediating the cell cycle-specific transcription through the recruitment of RNAP-II to the MBF-bound G(1)/S-phase genes.
      Title: Deconvolution of chromatin immunoprecipitation-microarray (ChIP-chip) analysis of MBF occupancies reveals the temporal recruitment of Rep2 at the MBF target genes.
    4. Cds1-dependent stabilization of Rep2 is achieved through the inhibition/phosphorylation of APC/C-Ste9 at the onset of S-phase arrest.
      Title: A Cds1-mediated checkpoint protects the MBF activator Rep2 from ubiquitination by anaphase-promoting complex/cyclosome-Ste9 at S-phase arrest in fission yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables SAGA complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of MBF transcription complex EXP
    Inferred from Experiment
    more info
    		 PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    transcriptional activator MBF subunit Rep2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003423.3 Reference assembly

      Range
      1717703..1719322
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001021602.3 → NP_595705.1  transcriptional activator MBF subunit Rep2 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_595705.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q09824
    Nucleotide Protein
    Heading Accession and Version

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