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    hul5 ubiquitin-protein ligase E3 [ Schizosaccharomyces pombe (fission yeast) ]

    Gene ID: 2542770, updated on 18-Sep-2024

    Summary

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    Official Symbol
    hul5
    Official Full Name
    ubiquitin-protein ligase E3
    Primary source
    PomBase:SPAC167.07c
    Locus tag
    SPOM_SPAC167.07C
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Schizosaccharomyces pombe (strain: 972h-)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina; Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae; Schizosaccharomyces
    Also known as
    SPAC57A7.03c
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    Genomic context

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    See hul5 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    3
    Sequence:
    Chromosome: I; NC_003424.3 (1546262..1550081)

    Chromosome I - NC_003424.3Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene major poly(A) binding protein Pabp/Pab1 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene protein mug143 Neighboring gene protein Dbs2 Neighboring gene putative TIM23 translocase complex-associated motor subunit Pam17 Neighboring gene U4/U5/U6 small nuclear ribonucleoprotein complex subunit Snu66 Neighboring gene geranylgeranyltransferase type 2 beta subunit Ptb1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003424.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of 15 New Bypassable Essential Genes of Fission Yeast. Takeda A, et al. Cell Struct Funct, 2019 Sep 27. PMID 31474649, Free PMC Article
    2. A chaperone-assisted degradation pathway targets kinetochore proteins to ensure genome stability. Kriegenburg F, et al. PLoS Genet, 2014 Jan. PMID 24497846, Free PMC Article
    3. Expanded Interactome of the Intrinsically Disordered Protein Dss1. Schenstrøm SM, et al. Cell Rep, 2018 Oct 23. PMID 30355493, Free PMC Article
    4. Conservation and rewiring of functional modules revealed by an epistasis map in fission yeast. Roguev A, et al. Science, 2008 Oct 17. PMID 18818364, Free PMC Article
    5. Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, et al. Mol Cell, 2012 Jun 8. PMID 22681890, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by PomBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding ISM
    Inferred from Sequence Model
    more info
    		  
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol HDA PubMed 
    is_active_in nuclear envelope HDA PubMed 
    is_active_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    ubiquitin-protein ligase E3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003424.3 Reference assembly

      Range
      1546262..1550081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001018810.3 → NP_593378.1  ubiquitin-protein ligase E3 [Schizosaccharomyces pombe]

      See identical proteins and their annotated locations for NP_593378.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q1K9C4
      Conserved Domains (2) summary
      COG5021
      Location:155 → 1029
      HUL4; Ubiquitin-protein ligase [Posttranslational modification, protein turnover, chaperones]
      cd00078
      Location:676 → 1027
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein
    Heading Accession and Version

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