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    eif2ak2 eukaryotic translation initiation factor 2-alpha kinase 2 [ Oncorhynchus mykiss (rainbow trout) ]

    Gene ID: 100271898, updated on 8-Mar-2024

    Summary

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    Gene symbol
    eif2ak2
    Gene description
    eukaryotic translation initiation factor 2-alpha kinase 2
    See related
    Ensembl:ENSOMYG00000027396
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Oncorhynchus mykiss
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes; Salmonidae; Salmoninae; Oncorhynchus
    Also known as
    pkr
    Orthologs
    human zebrafish all
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    Genomic context

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    See eif2ak2 in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    101 current USDA_OmykA_1.1 (GCF_013265735.2) 16 NC_048580.1 (2252487..2288576, complement)
    100 previous assembly Omyk_1.0 (GCF_002163495.1) 16 NC_035092.1 (422929..440889, complement)

    Chromosome 16 - NC_048580.1Genomic Context describing neighboring genes Neighboring gene vegetative cell wall protein gp1-like Neighboring gene protein kinase containing Z-DNA binding domains Neighboring gene G patch domain containing 11 Neighboring gene HEAT repeat containing 5B

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    interferon-induced, double-stranded RNA-activated protein kinase
    Names
    dsRNA-activated protein kinase R
    NP_001139363.1
    XP_036801653.1
    XP_036801654.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145891.1 → NP_001139363.1  interferon-induced, double-stranded RNA-activated protein kinase

      See identical proteins and their annotated locations for NP_001139363.1

      Status: PROVISIONAL

      Source sequence(s)
      EF523423
      UniProtKB/TrEMBL
      A0A8L0DRU9, C0SKM8
      Related
      ENSOMYP00000134084.1, ENSOMYT00000116111.1
      Conserved Domains (4) summary
      smart00220
      Location:462 → 735
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      smart00358
      Location:278 → 343
      DSRM; Double-stranded RNA binding motif
      cd00048
      Location:5 → 70
      DSRM; Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III, ...
      cl21453
      Location:456 → 738
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: Oncorhynchus mykiss Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference USDA_OmykA_1.1 Primary Assembly

    Genomic

    1. NC_048580.1 Reference USDA_OmykA_1.1 Primary Assembly

      Range
      2252487..2288576 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036945759.1 → XP_036801654.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X2

      UniProtKB/TrEMBL
      A0A8L0DRU9
      Conserved Domains (3) summary
      cd20314
      Location:150 → 216
      DSRM_EIF2AK2; double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cl00054
      Location:4 → 73
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl21453
      Location:456 → 738
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036945758.1 → XP_036801653.1  interferon-induced, double-stranded RNA-activated protein kinase isoform X1

      UniProtKB/TrEMBL
      A0A8C7S0P3, A0A8L0DRU9
      Related
      ENSOMYP00000059286.2, ENSOMYT00000064538.2
      Conserved Domains (3) summary
      cd20314
      Location:150 → 216
      DSRM_EIF2AK2; double-stranded RNA binding motif of eukaryotic translation initiation factor 2-alpha kinase 2 (EIF2AK2) and similar proteins
      cl00054
      Location:4 → 73
      DSRM_SF; double-stranded RNA binding motif (DSRM) superfamily
      cl21453
      Location:457 → 739
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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