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    Apbb3 amyloid beta precursor protein binding family B member 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117026, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Apbb3provided by RGD
    Official Full Name
    amyloid beta precursor protein binding family B member 3provided by RGD
    Primary source
    RGD:620853
    See related
    EnsemblRapid:ENSRNOG00000017849 AllianceGenome:RGD:620853
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fe65l2
    Summary
    Enables amyloid-beta binding activity. Involved in negative regulation of cell cycle phase transition and negative regulation of transcription by RNA polymerase II. Located in nucleus. Orthologous to human APBB3 (amyloid beta precursor protein binding family B member 3). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 139.9), Adrenal (RPKM 116.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Apbb3 in Genome Data Viewer
    Location:
    18p11
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (28547205..28554383, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (28273168..28280347, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (29497865..29504995, complement)

    Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene ankyrin repeat and KH domain containing 1 Neighboring gene eukaryotic translation initiation factor 4E binding protein 3 Neighboring gene SLC35A4 upstream open reading frame protein-like Neighboring gene Riken cDNA E230025N22 gene like Neighboring gene steroid receptor RNA activator 1 Neighboring gene solute carrier family 35, member A4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Fe65, a ligand of the Alzheimer's beta-amyloid precursor protein, blocks cell cycle progression by down-regulating thymidylate synthase expression. Bruni P, et al. J Biol Chem, 2002 Sep 20. PMID 12089154
    2. Fe65L2: a new member of the Fe65 protein family interacting with the intracellular domain of the Alzheimer's beta-amyloid precursor protein. Duilio A, et al. Biochem J, 1998 Feb 15. PMID 9461550, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables amyloid-beta binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables amyloid-beta binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables amyloid-beta binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables low-density lipoprotein particle receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables low-density lipoprotein particle receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell cycle phase transition IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein secretion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of protein secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    amyloid-beta A4 precursor protein-binding family B member 3
    Names
    amyloid beta (A4) precursor protein-binding, family B, member 3
    fe65-like protein 2
    protein Fe65-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053957.2 → NP_446409.2  amyloid-beta A4 precursor protein-binding family B member 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000018
      UniProtKB/Swiss-Prot
      O35827
      UniProtKB/TrEMBL
      F1LPF8
      Related
      ENSRNOP00000024313.5, ENSRNOT00000024313.7
      Conserved Domains (3) summary
      smart00456
      Location:30 → 61
      WW; Domain with 2 conserved Trp (W) residues
      cd01271
      Location:281 → 411
      PTB2_Fe65; Fe65 C-terminal Phosphotyrosine-binding (PTB) domain
      cd01272
      Location:114 → 252
      PTB1_Fe65; Fe65 N-terminal Phosphotyrosine-binding (PTB) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086036.1 Reference GRCr8

      Range
      28547205..28554383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063277070.1 → XP_063133140.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform X2

    2. XM_063277069.1 → XP_063133139.1  amyloid-beta A4 precursor protein-binding family B member 3 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O35827.1 GenPept UniProtKB/Swiss-Prot:O35827

    Gene LinkOut

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