Birc5 baculoviral IAP repeat-containing 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Birc5provided by RGD
Official Full Name: baculoviral IAP repeat-containing 5provided by RGD
Primary source: RGD:70499
See related: EnsemblRapid:ENSRNOG00000050819 AllianceGenome:RGD:70499
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: AP14
Summary: Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; protein dimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to ethanol; cellular response to stem cell factor stimulus; and response to glucocorticoid. Located in apical plasma membrane. Used to study endometriosis and pulmonary hypertension. Biomarker of acute pancreatitis (multiple); artery disease (multiple); congestive heart failure; high grade glioma; and stomach carcinoma. Human ortholog(s) of this gene implicated in prostate cancer and transitional cell carcinoma. Orthologous to human BIRC5 (baculoviral IAP repeat containing 5). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 156.5), Spleen (RPKM 102.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.2

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (103567369..103580069)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (103072530..103081382)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (106856097..106864419)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Survivin (BIRC5) regulates bladder fibrosis in a rat model of partial bladder outlet obstruction.
Title: Survivin ( BIRC5 ) regulates bladder fibrosis in a rat model of partial bladder outlet obstruction.
Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation.
Title: Protective effects of 6-gingerol on 6-hydroxydopamine-induced apoptosis in PC12 cells through modulation of SAPK/JNK and survivin activation.
Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose.
Title: Elevated MST1 leads to apoptosis via depletion of YAP1 in cardiomyocytes exposed to high glucose.
survivin overexpression in the ischemic boundary zone induced by using an AAV vector has the potential for amelioration of ischemic damage via an antiapoptotic mechanism
Title: Survivin overexpression via adeno-associated virus vector Rh10 ameliorates ischemic damage after middle cerebral artery occlusion in rats.
YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.
Title: YM155, a selective survivin inhibitor, reverses chronic hypoxic pulmonary hypertension in rats via upregulating voltage-gated potassium channels.
transformed MSCs express high levels of a p53 mutant that loses the ability to bind survivin gene
Title: Loss of interactions between p53 and survivin gene in mesenchymal stem cells after spontaneous transformation in vitro.
Reciprocal regulation of BMF and BIRC5 is linked to Eomes overexpression in colorectal cancer.
Title: Reciprocal regulation of BMF and BIRC5 (Survivin) linked to Eomes overexpression in colorectal cancer.
Cytoplasmic and nuclear immunostaining for bax, caspase-3, calpain-1 and survivin proteins were found in the endometrial epithelium and stromal cells.
Title: Involution dependent changes in distribution and localization of bax, survivin, caspase-3, and calpain-1 in the rat endometrium.
Survivin contributed to the development and progression of diabetic retinopathy through the HIF-1alpha pathway and become an important progression marker of diabetic retinopathy.
Title: Survivin contributes to the progression of diabetic retinopathy through HIF-1α pathway.
NAIP and survivin expressions were significantly reduced following varicocele induction when compared to sham animals whereas PDRN-treated rats showed an increase in NAIP and survivin levels.
Title: Role of Inhibitors of Apoptosis Proteins in Testicular Function and Male Fertility: Effects of Polydeoxyribonucleotide Administration in Experimental Varicocele.

Submit: New GeneRIF Correction See all GeneRIFs (44)

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables microtubule binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein-folding chaperone binding	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISO Inferred from Sequence Orthology more info
enables tubulin binding	ISS Inferred from Sequence or Structural Similarity more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in G2/M transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in G2/M transition of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cell division	ISO Inferred from Sequence Orthology more info
involved_in cell division	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to stem cell factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
involved_in establishment of chromosome localization	ISO Inferred from Sequence Orthology more info
involved_in establishment of chromosome localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in meiosis I	IEA Inferred from Electronic Annotation more info
involved_in meiosis I	ISO Inferred from Sequence Orthology more info
involved_in microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	ISO Inferred from Sequence Orthology more info
involved_in mitotic cytokinesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle assembly checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic spindle assembly checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitotic spindle organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of neuron apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of exit from mitosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exit from mitosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein-containing complex localization	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex localization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of insulin secretion involved in cellular response to glucose stimulus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in regulation of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of type B pancreatic cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of type B pancreatic cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in centriole	ISO Inferred from Sequence Orthology more info
located_in centriole	ISS Inferred from Sequence or Structural Similarity more info
part_of chromosome passenger complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chromosome passenger complex	ISO Inferred from Sequence Orthology more info
part_of chromosome passenger complex	ISS Inferred from Sequence or Structural Similarity more info
is_active_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISO Inferred from Sequence Orthology more info
located_in chromosome, centromeric region	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic microtubule	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic microtubule	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in interphase microtubule organizing center	ISO Inferred from Sequence Orthology more info
located_in interphase microtubule organizing center	ISS Inferred from Sequence or Structural Similarity more info
is_active_in kinetochore	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in midbody	IEA Inferred from Electronic Annotation more info
located_in midbody	ISO Inferred from Sequence Orthology more info
located_in midbody	ISS Inferred from Sequence or Structural Similarity more info
located_in nuclear chromosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISO Inferred from Sequence Orthology more info
located_in spindle microtubule	ISS Inferred from Sequence or Structural Similarity more info
is_active_in spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
part_of survivin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: baculoviral IAP repeat-containing protein 5

Names: apoptosis inhibitor survivin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_022274.2 → NP_071610.2 baculoviral IAP repeat-containing protein 5

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q9JHY7

UniProtKB/TrEMBL

A6HL35

Conserved Domains (1) summary

pfam00653
Location:18 → 88

BIR; Inhibitor of Apoptosis domain