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    Mob2 MOB kinase activator 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499288, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Mob2provided by RGD
    Official Full Name
    MOB kinase activator 2provided by RGD
    Primary source
    RGD:1562983
    See related
    EnsemblRapid:ENSRNOG00000020044 AllianceGenome:RGD:1562983
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Hcca2; RGD1562983
    Summary
    Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within actin cytoskeleton organization; positive regulation of neuron projection development; and positive regulation of protein phosphorylation. Predicted to be located in cytosol; neuron projection terminus; and nuclear lumen. Predicted to be active in cytoplasm and nucleus. Orthologous to human MOB2 (MOB kinase activator 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 214.5), Muscle (RPKM 201.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mob2 in Genome Data Viewer
    Location:
    1q41
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (206522523..206579502, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (197092991..197149978, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (214953992..214962106, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene toll interacting protein Neighboring gene uncharacterized LOC134485203 Neighboring gene BR serine/threonine kinase 2 Neighboring gene dual specificity phosphatase 8 Neighboring gene keratin associated protein 5-5 like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway. Fang KM, et al. J Cell Biochem, 2012 Sep. PMID 22566124
    2. The promotion of neurite formation in Neuro2A cells by mouse Mob2 protein. Lin CH, et al. FEBS Lett, 2011 Feb 4. PMID 21237165
    3. Characterization of the piRNA complex from rat testes. Lau NC, et al. Science, 2006 Jul 21. PMID 16778019
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data suggest that Mob2 is involved in PKA signaling-mediated astrocytic stellation.
      Title: Mps one binder 2 gene upregulation in the stellation of astrocytes induced by cAMP-dependent pathway.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables protein kinase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in neuron projection terminus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MOB kinase activator 2
    Names
    Mps one binder kinase activator-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109159.2 → NP_001102629.1  MOB kinase activator 2

      See identical proteins and their annotated locations for NP_001102629.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6ABE4, A6HY34
      Related
      ENSRNOP00000091325.2, ENSRNOT00000118667.2
      Conserved Domains (1) summary
      pfam03637
      Location:32 → 200
      Mob1_phocein; Mob1/phocein family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      206522523..206579502 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039087879.2 → XP_038943807.1  MOB kinase activator 2 isoform X5

      Conserved Domains (1) summary
      pfam03637
      Location:32 → 140
      Mob1_phocein; Mob1/phocein family

    2. XM_039087874.2 → XP_038943802.1  MOB kinase activator 2 isoform X4

      Conserved Domains (1) summary
      pfam03637
      Location:5 → 115
      Mob1_phocein; Mob1/phocein family

    3. XM_039087872.2 → XP_038943800.1  MOB kinase activator 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ABE4
      Related
      ENSRNOP00000027195.6, ENSRNOT00000027195.8
      Conserved Domains (1) summary
      pfam03637
      Location:30 → 198
      Mob1_phocein; Mob1/phocein family

    4. XM_039087871.2 → XP_038943799.1  MOB kinase activator 2 isoform X1

      UniProtKB/TrEMBL
      A0A8I6ABE4, A6HY35, D3ZLX3
      Related
      ENSRNOP00000108107.1, ENSRNOT00000128983.1
      Conserved Domains (1) summary
      pfam03637
      Location:63 → 231
      Mob1_phocein; Mob1/phocein family

    5. XM_039087873.2 → XP_038943801.1  MOB kinase activator 2 isoform X3

      Conserved Domains (1) summary
      pfam03637
      Location:63 → 171
      Mob1_phocein; Mob1/phocein family
    Nucleotide Protein Strain
    Heading Accession and Version

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