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    Grk5 G protein-coupled receptor kinase 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 59075, updated on 14-Nov-2024

    Summary

    Official Symbol
    Grk5provided by RGD
    Official Full Name
    G protein-coupled receptor kinase 5provided by RGD
    Primary source
    RGD:61985
    See related
    EnsemblRapid:ENSRNOG00000011439 AllianceGenome:RGD:61985
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gprk5
    Summary
    Predicted to enable beta-adrenergic receptor kinase activity and protein serine/threonine kinase activity. Involved in negative regulation of G protein-coupled receptor signaling pathway; oligodendrocyte differentiation; and response to cocaine. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be active in cytoplasm. Biomarker of Parkinson's disease and hypertension. Orthologous to human GRK5 (G protein-coupled receptor kinase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 258.1), Heart (RPKM 102.4) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Grk5 in Genome Data Viewer
    Location:
    1q55
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (270014314..270208294)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (260028269..260223699)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (282265371..282467842)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene sideroflexin 4 Neighboring gene uncharacterized LOC134485269 Neighboring gene peroxiredoxin 3 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene RNA, U6 small nuclear 28 Neighboring gene zinc finger protein 950 Neighboring gene zinc finger protein 933

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Clone Names

    • MGC93405

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ATP binding  
    enables G protein-coupled receptor kinase activity PubMed 
    enables G protein-coupled receptor kinase activity  
    enables beta-adrenergic receptor kinase activity  
    enables lipid binding  
    enables protein kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity  
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway  
    involved_in apoptotic process  
    involved_in desensitization of G protein-coupled receptor signaling pathway PubMed 
    involved_in fat cell differentiation  
    involved_in fat cell differentiation  
    involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
    involved_in negative regulation of apoptotic process  
    involved_in negative regulation of apoptotic process  
    involved_in oligodendrocyte differentiation PubMed 
    involved_in positive regulation of cell population proliferation  
    involved_in protein autophosphorylation  
    involved_in protein autophosphorylation  
    involved_in regulation of G protein-coupled receptor signaling pathway PubMed 
    involved_in regulation of cell cycle  
    involved_in regulation of signal transduction  
    involved_in response to cocaine PubMed 
    involved_in signal transduction  
    involved_in tachykinin receptor signaling pathway  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytosol  
    located_in nuclear membrane  
    located_in nuclear speck  
    located_in nucleus  
    located_in plasma membrane  
    located_in plasma membrane  

    General protein information

    Preferred Names
    G protein-coupled receptor kinase 5
    Names
    g protein-coupled receptor kinase GRK5
    NP_110456.2
    XP_038944728.1
    XP_038944729.1
    XP_038944734.1
    XP_038944738.1
    XP_038944748.1
    XP_038944755.1
    XP_038944756.1
    XP_063128278.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030829.2NP_110456.2  G protein-coupled receptor kinase 5

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q62833
      UniProtKB/TrEMBL
      A6JIB2, F7EZU6, Q66HL7
      Related
      ENSRNOP00000015687.4, ENSRNOT00000015687.8
      Conserved Domains (2) summary
      cd05632
      Location:183495
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:53175
      RGS; Regulator of G protein signaling (RGS) domain superfamily

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      270014314..270208294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039088820.2XP_038944748.1  G protein-coupled receptor kinase 5 isoform X5

      UniProtKB/Swiss-Prot
      Q62833
      Conserved Domains (2) summary
      cd05605
      Location:235472
      STKc_GRK4_like; Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases
      cl02565
      Location:74225
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    2. XM_039088800.2XP_038944728.1  G protein-coupled receptor kinase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q62833
      Conserved Domains (2) summary
      cd05632
      Location:233545
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:74225
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    3. XM_039088827.2XP_038944755.1  G protein-coupled receptor kinase 5 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZX64
      Conserved Domains (2) summary
      cd05632
      Location:180492
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:21172
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    4. XM_039088810.2XP_038944738.1  G protein-coupled receptor kinase 5 isoform X4

      UniProtKB/Swiss-Prot
      Q62833
      Conserved Domains (2) summary
      cd05632
      Location:204516
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:74196
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    5. XM_039088806.2XP_038944734.1  G protein-coupled receptor kinase 5 isoform X3

      UniProtKB/Swiss-Prot
      Q62833
      Related
      ENSRNOP00000104808.1, ENSRNOT00000139040.1
      Conserved Domains (2) summary
      cd05632
      Location:212524
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:53204
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    6. XM_039088801.2XP_038944729.1  G protein-coupled receptor kinase 5 isoform X2

      UniProtKB/Swiss-Prot
      Q62833
      Conserved Domains (2) summary
      cd05632
      Location:225537
      STKc_GRK5; Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5
      cl02565
      Location:66217
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    7. XM_063272208.1XP_063128278.1  G protein-coupled receptor kinase 5 isoform X8

    8. XM_039088828.2XP_038944756.1  G protein-coupled receptor kinase 5 isoform X7

      Conserved Domains (1) summary
      cl21453
      Location:4300
      PKc_like; Protein Kinases, catalytic domain
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