Icam2 intercellular adhesion molecule 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Icam2provided by RGD
Official Full Name: intercellular adhesion molecule 2provided by RGD
Primary source: RGD:1359660
See related: EnsemblRapid:ENSRNOG00000025143 AllianceGenome:RGD:1359660
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable integrin binding activity. Predicted to be involved in cell adhesion. Predicted to be located in cleavage furrow; microvillus; and uropod. Predicted to be active in plasma membrane. Orthologous to human ICAM2 (intercellular adhesion molecule 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 320.7), Thymus (RPKM 258.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (91808449..91819319, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (91308608..91319536, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (94569889..94581218, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

flotillin-2 is involved with adhesion between UECs and the implanting blastocyst, whereas ICAM-2 is associated with the ability for UECs to be removed at the time of implantation.
Title: ICAM-2 and lipid rafts disappear from the basal plasma membrane of uterine epithelial cells during early pregnancy in rats.
Data suggest that ICAM2 plays important role in apical dynamics/sperm head during spermatogenesis; ICAM2 surrounds heads of elongating/elongated spermatids in all stages of seminiferous epithelial cycle.
Title: Intercellular adhesion molecule-2 is involved in apical ectoplasmic specialization dynamics during spermatogenesis in the rat.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell periphery	ISO Inferred from Sequence Orthology more info
located_in cleavage furrow	ISO Inferred from Sequence Orthology more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in uropod	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: intercellular adhesion molecule 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007725.1 → NP_001007726.1 intercellular adhesion molecule 2 precursor

See identical proteins and their annotated locations for NP_001007726.1

Status: PROVISIONAL

Source sequence(s)

BC079465

UniProtKB/TrEMBL

F7F7V6, Q6AXM6

Related

ENSRNOP00000034319.3, ENSRNOT00000035474.5

Conserved Domains (2) summary

pfam03921
Location:24 → 111

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:114 → 205

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

91808449..91819319 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269470.1 → XP_063125540.1 intercellular adhesion molecule 2 isoform X3

UniProtKB/TrEMBL

A6HK43
XM_006247624.5 → XP_006247686.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_006247686.1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6

Conserved Domains (2) summary

pfam03921
Location:24 → 111

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:114 → 205

Ig; Immunoglobulin domain
XM_006247627.5 → XP_006247689.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_006247689.1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6

Conserved Domains (2) summary

pfam03921
Location:24 → 111

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:114 → 205

Ig; Immunoglobulin domain
XM_063269464.1 → XP_063125534.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_063269466.1 → XP_063125536.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_008768379.4 → XP_008766601.1 intercellular adhesion molecule 2 isoform X1

See identical proteins and their annotated locations for XP_008766601.1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6

Conserved Domains (2) summary

pfam03921
Location:24 → 111

ICAM_N; Intercellular adhesion molecule (ICAM), N-terminal domain

cl11960
Location:114 → 205

Ig; Immunoglobulin domain
XM_063269465.1 → XP_063125535.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_063269467.1 → XP_063125537.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_063269463.1 → XP_063125533.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_063269469.1 → XP_063125539.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_063269468.1 → XP_063125538.1 intercellular adhesion molecule 2 isoform X1

UniProtKB/TrEMBL

F7F7V6, Q6AXM6
XM_039086420.2 → XP_038942348.1 intercellular adhesion molecule 2 isoform X2

UniProtKB/TrEMBL

A0A8I5ZNQ0

Related

ENSRNOP00000079806.1, ENSRNOT00000115213.2

Conserved Domains (3) summary

cd00096
Location:113 → 120

Ig; Ig strand A [structural motif]

cd20995
Location:27 → 111

IgI_N_ICAM-2; N-terminal immunoglobulin domain of the intercellular adhesion molecules ICAM-2 (Cluster of Differentiation 102 or CD102); member of the I-set of IgSF domains

cl11960
Location:113 → 210

Ig; Immunoglobulin domain